The role of tuberous sclerosis complex 1 in regulating innate immunity - Wikidata - awgldk - TriplyDB

The role of tuberous sclerosis complex 1 in regulating innate immunity

The role of tuberous sclerosis complex 1 in regulating innate immunity

http://www.wikidata.org/entity/Q35884070

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Immune responsive gene 1 (IRG1) promotes endotoxin tolerance by increasing A20 expression in macrophages through reactive oxygen species Control of macrophage metabolism and activation by mTOR and Akt signaling Disruption of mammalian target of rapamycin complex 1 in macrophages decreases chemokine gene expression and atherosclerosis.Role of tumor suppressor TSC1 in regulating antigen-specific primary and memory CD8 T cell responses to bacterial infection.Diacylglycerol kinase zeta positively controls the development of iNKT-17 cells.TSC1 Promotes B Cell Maturation but Is Dispensable for Germinal Center Formation Sustained activation of mTORC1 in macrophages increases AMPKα-dependent autophagy to maintain cellular homeostasis p38α senses environmental stress to control innate immune responses via mechanistic target of rapamycin Critical role of the tumor suppressor tuberous sclerosis complex 1 in dendritic cell activation of CD4 T cells by promoting MHC class II expression via IRF4 and CIITA.T cell Receptor Signal Transduction in T lymphocytes.TSC1 controls IL-1β expression in macrophages via mTORC1-dependent C/EBPβ pathway.mTORC1-Activated Monocytes Increase Tregs and Inhibit the Immune Response to Bacterial Infections.Tuberous sclerosis 1 (Tsc1)-dependent metabolic checkpoint controls development of dendritic cells.Mechanistic target of rapamycin complex 1 is critical for invariant natural killer T-cell development and effector function.Rheb1 deletion in myeloid cells aggravates OVA-induced allergic inflammation in mice.Chronic signaling via the metabolic checkpoint kinase mTORC1 induces macrophage granuloma formation and marks sarcoidosis progression.Tuberous sclerosis 1 promotes invariant NKT cell anergy and inhibits invariant NKT cell-mediated antitumor immunity.iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions.Immune responses of macrophages and dendritic cells regulated by mTOR signalling.mTOR and its tight regulation for iNKT cell development and effector function.Regulation of innate immune cell function by mTOR.mTOR-Mediated Regulation of Dendritic Cell Differentiation and Function.Innate Immune Regulations and Liver Ischemia-Reperfusion Injury.Akt Signaling Pathway in Macrophage Activation and M1/M2 Polarization.Vascular hyperpermeability as a hallmark of phacomatoses: is the etiology angiogenesis related to or comparable with mechanisms seen in inflammatory pathways? Part II: angiogenesis- and inflammation-related molecular pathways, tumor-associated macro Vibrio vulnificus induces mTOR activation and inflammatory responses in macrophages.mTOR regulates TLR-induced c-fos and Th1 responses to HBV and HCV vaccines.The TSC-mTOR pathway regulates macrophage polarization.An expanded role of the tumor suppressor TSC1 in T cell tolerance mTORC2 Signaling Selectively Regulates the Generation and Function of Tissue-Resident Peritoneal Macrophages.Rapamycin unbalances the polarization of human macrophages to M1.Molecular Mechanisms Modulating the Phenotype of Macrophages and Microglia.Essential Role of mTORC1 in Self-Renewal of Murine Alveolar Macrophages.The effects of everolimus on tuberous sclerosis-associated lesions can be dramatic but may be impermanent.Harnessing the mTOR Pathway for Tuberculosis Treatment.Mammalian Target of Rapamycin Inhibition in Trypanosoma cruzi-Infected Macrophages Leads to an Intracellular Profile That Is Detrimental for Infection.Effects of the mTOR inhibitor everolimus and the PI3K/mTOR inhibitor NVP-BEZ235 in murine acute lung injury models.

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The role of tuberous sclerosis complex 1 in regulating innate immunity

http://www.wikidata.org/entity/Q35884070

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2012年论文

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2012年论文

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2012年论文

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The role of tuberous sclerosis complex 1 in regulating innate immunity

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The role of tuberous sclerosis complex 1 in regulating innate immunity

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The role of tuberous sclerosis complex 1 in regulating innate immunity

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The role of tuberous sclerosis complex 1 in regulating innate immunity

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The role of tuberous sclerosis complex 1 in regulating innate immunity

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JIMMUNOL.1102187

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Journal of Immunology

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The role of tuberous sclerosis complex 1 in regulating innate immunity

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Hongjie Pan

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Ping Zhang

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Thomas F O'Brien

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Xiao-Ping Zhong

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P2860

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling

The TSC1-TSC2 complex: a molecular switchboard controlling cell growth

The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6)

mTOR regulates memory CD8 T-cell differentiation

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

Pattern recognition receptors and inflammation

A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

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3658-3666

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