Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF - Wikidata - awgldk - TriplyDB

Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF

Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF

http://www.wikidata.org/entity/Q35889683

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Role of PD-1 in HIV pathogenesis and as target for therapy Effector, Memory, and Dysfunctional CD8(+) T Cell Fates in the Antitumor Immune Response Targeting Transcriptional Regulators of CD8+ T Cell Dysfunction to Boost Anti-Tumor Immunity The anticancer immune response of anti-PD-1/PD-L1 and the genetic determinants of response to anti-PD-1/PD-L1 antibodies in cancer patients Molecular and cellular insights into T cell exhaustion Signature Channels of Excitability no More: L-Type Channels in Immune Cells Viewing transplantation immunology through today's lens: new models, new imaging, and new insights.Overcoming T cell exhaustion in infection and cancer New immunotherapies targeting the PD-1 pathway Profiling immunity to HIV vaccines with systems biology The enduring tale of T cells in HIV immunopathogenesis Characterization of CD8+ T cell differentiation following SIVΔnef vaccination by transcription factor expression profiling Memory T cells in transplantation - progress and challenges.Innate and Adaptive Immune Regulation During Chronic Viral Infections Blockade of the B7-H1/PD-1 pathway for cancer immunotherapy BET bromodomain inhibition enhances T cell persistence and function in adoptive immunotherapy models Longitudinal requirement for CD4+ T cell help for adenovirus vector-elicited CD8+ T cell responses.CD40 signaling to the rescue: A CD8 exhaustion perspective in chronic infectious diseases Differential Effect of Cytomegalovirus Infection with Age on the Expression of CD57, CD300a, and CD161 on T-Cell Subpopulations.T-bet and Eomes are differentially linked to the exhausted phenotype of CD8+ T cells in HIV infection The CD300 molecules: an emerging family of regulators of the immune system.Transcriptional control of effector and memory CD8+ T cell differentiation.Extended co-expression of inhibitory receptors by human CD8 T-cells depending on differentiation, antigen-specificity and anatomical localization.Programmed death-1 expression on HIV-1-specific CD8+ T cells is shaped by epitope specificity, T-cell receptor clonotype usage and antigen load.Loss and dysfunction of Vδ2⁺ γδ T cells are associated with clinical tolerance to malaria.IRF4 and BATF are critical for CD8⁺ T-cell function following infection with LCMV.Role of PD-1 co-inhibitory pathway in HIV infection and potential therapeutic options Distinctive features of CD4+ T cell dysfunction in chronic viral infections.Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8(+) Cytolytic T Cell Responses.The T-cell response to HIV.Impairment of the programmed cell death-1 pathway increases atherosclerotic lesion development and inflammation.Exhaustion of tumor-specific CD8⁺ T cells in metastases from melanoma patients Memories in the snow: immune memory, persistent infection and chronic disease Coherent functional modules improve transcription factor target identification, cooperativity prediction, and disease association Blockade of the programmed death-1 (PD1) pathway undermines potent genetic protection from type 1 diabetes.Responsiveness of HIV-specific CD4 T cells to PD-1 blockade Basic leucine zipper transcription factor, ATF-like (BATF) regulates epigenetically and energetically effector CD8 T-cell differentiation via Sirt1 expression Vaccine-elicited CD4 T cells induce immunopathology after chronic LCMV infection Characterization of an effective CTL response against HIV and SIV infections.T cell exhaustion during persistent viral infections.

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Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF

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2010年論文

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2010年论文

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2010年论文

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Transcriptional analysis of HI ...... function by upregulating BATF

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Transcriptional analysis of HI ...... function by upregulating BATF

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Transcriptional analysis of HI ...... function by upregulating BATF

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Transcriptional analysis of HI ...... function by upregulating BATF

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Transcriptional analysis of HI ...... function by upregulating BATF

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Transcriptional analysis of HI ...... function by upregulating BATF

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Nature Medicine

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Transcriptional analysis of HI ...... function by upregulating BATF

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Alison Crawford

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Benjamin Ebert

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Björn Nilsson

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Boris Julg

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Catia Fonseca

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Daniel E Kaufmann

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Douglas Dolfi

http://www.w3.org/2001/XMLSchema#string

Douglas S Kwon

http://www.w3.org/2001/XMLSchema#string

E John Wherry

http://www.w3.org/2001/XMLSchema#string

Filippos Porichis

http://www.w3.org/2001/XMLSchema#string

P2860

CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

The AP-1 transcription factor Batf controls T(H)17 differentiation

Viral immune evasion due to persistence of activated T cells without effector function

Restoring function in exhausted CD8 T cells during chronic viral infection

Batf coordinates multiple aspects of B and T cell function required for normal antibody responses

HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells

PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

Up on the tightrope: natural killer cell activation and inhibition

High-throughput gene expression profiling of memory differentiation in primary human T cells.

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1147-1151

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scholarly article

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10.1038/NM.2232

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P433

10

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16

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Bruce D. Walker

Florencia Pereyra

Alicja Piechocka-Trocha

P577

2010-10-03T00:00:00Z

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47300807

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20890291

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3326577

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