Principles and applicability of CSF sampling for the assessment of CNS drug delivery and pharmacodynamics.
about
The Rationale for Insulin Therapy in Alzheimer's DiseaseITC recommendations for transporter kinetic parameter estimation and translational modeling of transport-mediated PK and DDIs in humansAbsorption and distribution of etoricoxib in plasma, CSF, and wound tissue in patients following hip surgery--a pilot study.Rapid fluorescence imaging of spinal cord following epidural administration of a nerve-highlighting fluorophore.Translational pharmacokinetics: challenges of an emerging approach to drug development in stroke.Drug metabolism and pharmacokinetics, the blood-brain barrier, and central nervous system drug discovery.Brainpeps: the blood-brain barrier peptide database.Single compartment drug delivery.Role of ATP-binding cassette and solute carrier transporters in erlotinib CNS penetration and intracellular accumulation.Apolipoprotein E does not cross the blood-cerebrospinal fluid barrier, as revealed by an improved technique for sampling CSF from miceThe mastermind approach to CNS drug therapy: translational prediction of human brain distribution, target site kinetics, and therapeutic effects.Cerebral microdialysis in clinical studies of drugs: pharmacokinetic applicationsLow penetration of oseltamivir and its carboxylate into cerebrospinal fluid in healthy Japanese and Caucasian volunteersOn the rate and extent of drug delivery to the brain.Unconditioned behavioral effects of the powerful kappa-opioid hallucinogen salvinorin A in nonhuman primates: fast onset and entry into cerebrospinal fluidPhysiologically based pharmacokinetic modelling of drug penetration across the blood-brain barrier--towards a mechanistic IVIVE-based approachTurnover rate of cerebrospinal fluid in female sheep: changes related to different light-dark cycles.Intracerebral Distribution of the Oncometabolite d-2-Hydroxyglutarate in Mice Bearing Mutant Isocitrate Dehydrogenase Brain Tumors: Implications for Tumorigenesis.Drug interactions at the blood-brain barrier: fact or fantasy?Neurobehavioral and Antioxidant Effects of Ethanolic Extract of Yellow PropolisPharmacokinetics and pharmacodynamics utilizing unbound target tissue exposure as part of a disposition-based rationale for lead optimization of benzoxaboroles in the treatment of Stage 2 Human African Trypanosomiasis.Efavirenz Is Predicted To Accumulate in Brain Tissue: an In Silico, In Vitro, and In Vivo Investigation.Assessing brain free fraction in early drug discovery.Development of a physiologically-based pharmacokinetic model of the rat central nervous system.Central nervous system delivery of large molecules: challenges and new frontiers for intrathecally administered therapeutics.Collection of biological samples in forensic toxicology.Nanostructure-based drug delivery systems for brain targeting.Physiologically based pharmacokinetic modeling to investigate regional brain distribution kinetics in rats.CSF penetration by antiretroviral drugs.Utility of CSF in translational neuroscience.Strategies to assess blood-brain barrier penetration.Overview of experimental models of the blood-brain barrier in CNS drug discovery.Reliability of In Vitro and In Vivo Methods for Predicting the Effect of P-Glycoprotein on the Delivery of Antidepressants to the Brain.Pharmacokinetics and pharmacodynamics of intrathecally administered Xen2174, a synthetic conopeptide with norepinephrine reuptake inhibitor and analgesic properties.Refinement of a model of repeated cerebrospinal fluid collection in conscious rats.Comparison of brain extracellular fluid, brain tissue, cerebrospinal fluid, and serum concentrations of antiepileptic drugs measured intraoperatively in patients with intractable epilepsy.A modified method for cerebrospinal fluid collection in anesthetized rat and evaluation of the efficacy.Estrogen and insulin transport through the blood-brain barrierImproved measurement of drug exposure in the brain using drug-specific correction for residual blood.A computational model of cerebrospinal fluid production and reabsorption driven by Starling forces.
P2860
Q26744834-EAC5661C-B58C-45E0-A305-AFD75BE818B4Q27022933-F820B645-977B-4F53-950C-B6E60740B9FCQ33596397-DE870D85-4A5B-4206-B896-CAC23787B7A7Q33820988-FAFFA699-896B-4399-BCED-5EF1784F888EQ33882182-32DEE569-D14D-408E-9716-E20B5A8F00A6Q33946973-5439D3CC-056D-4B4A-9200-DE3A454346EDQ34243408-0C91B8C6-A293-4B83-818D-446D9779399EQ34263907-561EAD08-F525-4E8D-925B-891B3F72D911Q34472367-F9B578A2-DCAF-4361-87D1-EBC90D76C846Q36454486-057F8B10-6942-4828-8AD2-D208726D5BACQ36697929-2FAEAA8D-FBF9-4B0A-BE20-AC7E4CD9A3B2Q36872983-198D9F1E-D192-41BD-BBF7-F2C92FC4A154Q36932915-09920E5E-1E17-4F4B-A284-DFD725DB71F9Q37023904-D1DB1312-5117-49A0-82EB-201624D7F49BQ37192749-8191907D-8545-4061-84C7-B3663E137C67Q37207750-9FB6246F-A042-4A4C-A144-D2265DF7F6D4Q37316322-7F525CC4-B4C0-45A8-BCBF-2D6B5BC313B1Q37326123-D0E449B9-B1C1-43C8-B9C3-0885F2BACD79Q37362486-FA4EE3AE-51E5-4445-9532-E45A3ABFAB0EQ37378399-E08DF4AB-BC47-45E9-8083-6A0701319904Q37449679-655D7762-3D1F-41ED-B306-74E4388505DDQ37538717-27AC9AC1-816F-48A5-B4E3-1E58EA696AA6Q37681555-6F9600B7-1F44-432D-8C33-6EAFE1D69D5CQ37689854-F53DF22C-0B68-4F5E-A91C-6D6A49A25484Q37702246-ABF8DC3B-14CD-434E-83C9-B6EACAC5E2F5Q37771033-7D5E91D4-D5C3-456B-A183-EDF3405548C3Q37939942-4DFBDC91-BE45-4913-88EA-689C2D04C1DBQ38010342-7193E2C2-ED26-41F7-B885-8570AFABD3B5Q38060571-8DCA50BC-67AF-4C66-97A4-255C2AB13725Q38080762-B2502EA7-7E8B-4511-B318-8F10973E83ECQ38090672-DB372028-220C-484B-83A3-27762BC19625Q38186650-E304E899-F43A-4C78-BCAE-2FCB0A6996D1Q38570611-9E97CFC8-6BC2-44D1-8FD0-A1668E27E55CQ39093085-C1E73BC3-FC76-4F94-95E6-F2EC24AAEF86Q39836270-10F5EDC7-BA8F-4EE4-B832-CD4C922AC2B0Q40329175-FD54A4FA-2FEE-43BB-8FDA-EE7A6CCFFAE9Q41822879-88041362-031D-4BC6-AD7A-3423EBAA450FQ41856273-50239D43-FE9D-4109-B6AF-46DD18D42820Q41906434-31C24EC6-9C0C-4ADC-BF68-BEEAFFA80274Q42122877-7EE11B26-E77B-4F56-BBED-7AC68EBC3A5F
P2860
Principles and applicability of CSF sampling for the assessment of CNS drug delivery and pharmacodynamics.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Principles and applicability o ...... delivery and pharmacodynamics.
@ast
Principles and applicability o ...... delivery and pharmacodynamics.
@en
type
label
Principles and applicability o ...... delivery and pharmacodynamics.
@ast
Principles and applicability o ...... delivery and pharmacodynamics.
@en
prefLabel
Principles and applicability o ...... delivery and pharmacodynamics.
@ast
Principles and applicability o ...... delivery and pharmacodynamics.
@en
P2093
P1476
Principles and applicability o ...... delivery and pharmacodynamics.
@en
P2093
Alan A Artru
Danny D Shen
Kimberly K Adkison
P304
P356
10.1016/J.ADDR.2004.07.011
P407
P577
2004-10-01T00:00:00Z