Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94
about
Paralog Specific Hsp90 Inhibitors - A Brief History and a Bright FutureGambogic acid identifies an isoform-specific druggable pocket in the middle domain of Hsp90βHigh expression of endoplasmic reticulum chaperone grp94 is a novel molecular hallmark of malignant plasma cells in multiple myelomaChemical Tools to Investigate Mechanisms Associated with HSP90 and HSP70 in Disease.A Human Variant of Glucose-Regulated Protein 94 That Inefficiently Supports IGF Production.Development of Glucose Regulated Protein 94-Selective Inhibitors Based on the BnIm and Radamide Scaffold5'-N-ethylcarboxamidoadenosine is not a paralog-specific Hsp90 inhibitor.Resorcinol-Based Grp94-Selective Inhibitors.Proteomic interrogation of HSP90 and insights for medical research.Structure Based Design of a Grp94-Selective Inhibitor: Exploiting a Key Residue in Grp94 To Optimize Paralog-Selective Binding.
P2860
Q26748800-180C6851-6173-4BBA-89F4-6339908A39CCQ28829208-AE19AB77-978A-40B9-A5F3-3773643EC589Q35789280-D67548B9-AC81-488C-8AC1-60F9C74B4B35Q36655158-85E56F96-324A-4AE2-BFC4-3535AE089B9DQ36911625-8250B170-7C47-4373-A901-03597BB7C237Q37164519-BABFFC0F-A927-4E5A-B98E-5AAC51CCF7F3Q44586980-C36F911E-744D-45F0-807B-C6A27A348B2BQ47619180-7DD046D1-60AA-4EE5-B2B9-06CD132D9E4EQ47678542-7F94C739-B274-4F8D-B557-8CB91A9562BDQ52660986-78A79C6C-03DE-486E-B4AB-7A29AAB77A1C
P2860
Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94
description
2015 nî lūn-bûn
@nan
2015年の論文
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2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
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2015年论文
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name
Structure-activity relationshi ...... reticulum Hsp90 paralog Grp94
@ast
Structure-activity relationshi ...... reticulum Hsp90 paralog Grp94
@en
type
label
Structure-activity relationshi ...... reticulum Hsp90 paralog Grp94
@ast
Structure-activity relationshi ...... reticulum Hsp90 paralog Grp94
@en
prefLabel
Structure-activity relationshi ...... reticulum Hsp90 paralog Grp94
@ast
Structure-activity relationshi ...... reticulum Hsp90 paralog Grp94
@en
P2093
P2860
P1476
Structure-activity relationshi ...... reticulum Hsp90 paralog Grp94
@en
P2093
Alexander Bolaender
Cynthia Leifer
Daniel T Gewirth
Elisa Tramentozzi
Hardik J Patel
James Brooks
Liza Shrestha
Maulik R Patel
Pallav D Patel
Paola Finotti
P2860
P304
P356
10.1021/ACS.JMEDCHEM.5B00197
P407
P577
2015-04-22T00:00:00Z