Cysteine cathepsins are essential in lysosomal degradation of α-synuclein.
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Vacuolar Protein Sorting Genes in Parkinson's Disease: A Re-appraisal of Mutations Detection Rate and Neurobiology of DiseaseLoss of Cathepsin B and L Leads to Lysosomal Dysfunction, NPC-Like Cholesterol Sequestration and Accumulation of the Key Alzheimer's ProteinsAcidic Ca2+ stores in neurodegeneration.α-Synuclein-induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models.Sorting out release, uptake and processing of alpha-synuclein during prion-like spread of pathology.ɑ-Synuclein strains and the variable pathologies of synucleinopathies.Endolysosomal dysfunction in Parkinson's disease: Recent developments and future challenges.The Complicated Relationship between Gaucher Disease and Parkinsonism: Insights from a Rare Disease.Ageing-induced changes in the redox status of peripheral motor nerves imply an effect on redox signalling rather than oxidative damage.The Neuroprotective Role of Protein Quality Control in Halting the Development of Alpha-Synuclein Pathology.The lysosomal enzyme alpha-Galactosidase A is deficient in Parkinson's disease brain in association with the pathologic accumulation of alpha-synuclein.Familial knockin mutation of LRRK2 causes lysosomal dysfunction and accumulation of endogenous insoluble α-synuclein in neurons.Effect of the cross-talk between autophagy and endoplasmic reticulum stress on Mn-induced alpha-synuclein oligomerization.Structural features of α-synuclein amyloid fibrils revealed by Raman spectroscopy.Behead and live long or the tale of cathepsin L.A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci.Taking a Bite Out of Amyloid: Mechanistic Insights into α-Synuclein Degradation by Cathepsin L.Lysosomal trafficking defects link Parkinson's disease with Gaucher's disease.Excessive burden of lysosomal storage disorder gene variants in Parkinson's disease.
P2860
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P2860
Cysteine cathepsins are essential in lysosomal degradation of α-synuclein.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Cysteine cathepsins are essential in lysosomal degradation of α-synuclein.
@ast
Cysteine cathepsins are essential in lysosomal degradation of α-synuclein.
@en
type
label
Cysteine cathepsins are essential in lysosomal degradation of α-synuclein.
@ast
Cysteine cathepsins are essential in lysosomal degradation of α-synuclein.
@en
prefLabel
Cysteine cathepsins are essential in lysosomal degradation of α-synuclein.
@ast
Cysteine cathepsins are essential in lysosomal degradation of α-synuclein.
@en
P2860
P356
P1476
Cysteine cathepsins are essential in lysosomal degradation of α-synuclein
@en
P2093
Ryan P McGlinchey
P2860
P304
P356
10.1073/PNAS.1500937112
P407
P577
2015-07-13T00:00:00Z