Biochemical and genetic analyses provide insight into the structural and mechanistic properties of actin filament disassembly by the Aip1p cofilin complex in Saccharomyces cerevisiae
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Aip1 destabilizes cofilin-saturated actin filaments by severing and accelerating monomer dissociation from ends.An order of magnitude faster AIP1-associated actin disruption than nucleation by the Arp2/3 complex in lamellipodiaCofilin-mediated sorting and export of specific cargo from the Golgi apparatus in yeastExpression of actin-interacting protein 1 suppresses impaired chemotaxis of Dictyostelium cells lacking the Na+-H+ exchanger NHE1WDR1 presence in the songbird basilar papilla.Novel interactions between actin and the proteasome revealed by complex haploinsufficiencyUnbalancing the phosphatidylinositol-4,5-bisphosphate-cofilin interaction impairs cell steering.Overlapping and distinct functions for cofilin, coronin and Aip1 in actin dynamics in vivoCoordination of the filament stabilizing versus destabilizing activities of cofilin through its secondary binding site on actinLinking genetics to structural biology: complex heterozygosity screening with actin alanine scan alleles identifies functionally related surfaces on yeast actin.The two actin-interacting protein 1 genes have overlapping and essential function for embryonic development in Caenorhabditis elegansInside view of cell locomotion through single-molecule: fast F-/G-actin cycle and G-actin regulation of polymer restoration.AIP1-mediated actin disassembly is required for postnatal germ cell migration and spermatogonial stem cell niche establishment.Actin disassembly by cofilin, coronin, and Aip1 occurs in bursts and is inhibited by barbed-end cappersImportance of a Lys113-Glu195 intermonomer ionic bond in F-actin stabilization and regulation by yeast formins Bni1p and Bnr1p.Actin-ADF/cofilin rod formation in Caenorhabditis elegans muscle requires a putative F-actin binding site of ADF/cofilin at the C-terminus.Functions of actin-interacting protein 1 (AIP1)/WD repeat protein 1 (WDR1) in actin filament dynamics and cytoskeletal regulation.
P2860
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P2860
Biochemical and genetic analyses provide insight into the structural and mechanistic properties of actin filament disassembly by the Aip1p cofilin complex in Saccharomyces cerevisiae
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Biochemical and genetic analys ...... ex in Saccharomyces cerevisiae
@ast
Biochemical and genetic analys ...... ex in Saccharomyces cerevisiae
@en
type
label
Biochemical and genetic analys ...... ex in Saccharomyces cerevisiae
@ast
Biochemical and genetic analys ...... ex in Saccharomyces cerevisiae
@en
prefLabel
Biochemical and genetic analys ...... ex in Saccharomyces cerevisiae
@ast
Biochemical and genetic analys ...... ex in Saccharomyces cerevisiae
@en
P2860
P1433
P1476
Biochemical and genetic analys ...... ex in Saccharomyces cerevisiae
@en
P2093
David C Amberg
Michael G Clark
P2860
P304
P356
10.1534/GENETICS.107.072066
P407
P577
2007-05-04T00:00:00Z