Targeted gene inactivation of calpain-1 suppresses cortical degeneration due to traumatic brain injury and neuronal apoptosis induced by oxidative stress.
about
The cysteine protease cathepsin B is a key drug target and cysteine protease inhibitors are potential therapeutics for traumatic brain injuryCysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitorsCathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug CandidateOxidative stress, DNA damage, and the telomeric complex as therapeutic targets in acute neurodegenerationLoss of Acid sensing ion channel-1a and bicarbonate administration attenuate the severity of traumatic brain injuryTargeting the nNOS/peroxynitrite/calpain system to confer neuroprotection and aid functional recovery in a mouse model of TBI.Differential Activation of Calpain-1 and Calpain-2 following Kainate-Induced Seizure Activity in Rats and Mice.Calpain-1 knockout reveals broad effects on erythrocyte deformability and physiology.Protection against TBI-Induced Neuronal Death with Post-Treatment with a Selective Calpain-2 Inhibitor in Mice.Degradomics in Neurotrauma: Profiling Traumatic Brain Injury.Repeated mild traumatic brain injury in female rats increases lipid peroxidation in neurons.Protective effects of PARP inhibitor, PJ34, is related to down-regulation of calpain and NF-κB in a mouse model of TBI.Effect and mechanism of calpains on pediatric lobar pneumonia.Phytoestrogen β-Ecdysterone Protects PC12 Cells Against MPP+-Induced Neurotoxicity In Vitro: Involvement of PI3K-Nrf2-Regulated Pathway.The tyrosine phosphatase PTPN13/FAP-1 links calpain-2, TBI and tau tyrosine phosphorylation.Therapeutic Efficacy of E-64-d, a Selective Calpain Inhibitor, in Experimental Acute Spinal Cord Injury.PDGF suppresses oxidative stress induced Ca2+ overload and calpain activation in neuronsProtective Effects of Calpain Inhibition on Neurovascular Unit Injury through Downregulating Nuclear Factor-κB-related Inflammation during Traumatic Brain Injury in Mice.Diffuse Axonal Injury and Oxidative Stress: A Comprehensive Review.Gene Profiling of Nucleus Basalis Tau Containing Neurons in Chronic Traumatic Encephalopathy: A Chronic Effects of Neurotrauma Consortium Study.Calpain-1 regulates platelet function in a humanized mouse model of sickle cell disease.Repeated Mild Traumatic Brain Injury: Potential Mechanisms of Damage.Regulatory role of calpain in neuronal death.
P2860
Q24601910-1B8A82DA-E729-4220-A8BE-F939E38621F1Q26771736-FE9C726D-42B3-426B-8CC7-FF5088690113Q26782938-B9B518D5-77F2-4EFD-A966-F9BBC262C5C3Q26995219-F4F38916-0C50-4A0F-BA6E-771F408C52B6Q34977089-8D9EC6FE-F33B-4BB2-A403-FDE9FBB6B2F0Q36386519-6CF82226-6C91-4C39-9759-3D621F686D69Q37232750-2E517765-30F3-40A8-9FC4-C7618C55E61BQ37638858-2287E041-A542-4640-A458-AB4BFA3297B9Q38736657-5A7914BF-2062-4A2D-BEDC-FA1A0B299CC5Q38784171-7B962840-B316-450A-9316-A4B6C7F9C61BQ38833405-ED76DE1E-4CCE-4893-9F59-3BD148874DBFQ39817883-EE4A281B-A520-4DEB-B49C-9F1247DEFE20Q40482309-5EB7236C-CE25-47C8-8E97-A5F56DA55C24Q40863972-24DC79F8-09AB-4916-9E02-7F9DBC65D854Q41718094-03DE26AD-F46B-4380-89F0-AF71541A1361Q41783608-BB66AF78-AEFD-4814-8E37-9ADDA5A4FA1BQ41862177-EF795A7A-008F-4562-A136-983AA85DE833Q42053602-29F1D8B4-FFA3-4104-B821-E246E69EF156Q46247593-B9FB6E59-48E5-4716-8861-4F7DE266DA64Q47654309-AF363AE0-05C7-431D-9E34-6A5CF984ADE5Q47666229-B6EEB3DE-F92B-46FC-9A82-8CEF4FE194A6Q52086737-F5D363B2-2853-4969-8A4F-AFAFFDB21575Q52721187-049DFC71-F6D9-442C-9EAC-608B4F974405
P2860
Targeted gene inactivation of calpain-1 suppresses cortical degeneration due to traumatic brain injury and neuronal apoptosis induced by oxidative stress.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Targeted gene inactivation of ...... s induced by oxidative stress.
@ast
Targeted gene inactivation of ...... s induced by oxidative stress.
@en
type
label
Targeted gene inactivation of ...... s induced by oxidative stress.
@ast
Targeted gene inactivation of ...... s induced by oxidative stress.
@en
prefLabel
Targeted gene inactivation of ...... s induced by oxidative stress.
@ast
Targeted gene inactivation of ...... s induced by oxidative stress.
@en
P2093
P2860
P356
P1476
Targeted gene inactivation of ...... s induced by oxidative stress.
@en
P2093
Adam J Wieschhaus
Athar H Chishti
Chinnaswamy Tiruppathi
Dorothy A Kozlowski
Imran Chishti
Ira M Herman
Kaori H Yamada
Premanand Sundivakkam
Shafi M Kuchay
Stacey E Seidl
P2860
P304
13182-13193
P356
10.1074/JBC.M111.302612
P407
P577
2012-02-24T00:00:00Z