The molecular mechanism by which PIP(2) opens the intracellular G-loop gate of a Kir3.1 channel.
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A Kir6.2 pore mutation causes inactivation of ATP-sensitive potassium channels by disrupting PIP2-dependent gating.Selective phosphorylation modulates the PIP2 sensitivity of the CaM-SK channel complexG protein-coupled receptor signaling to Kir channels in Xenopus oocytes.Identification of the Conformational transition pathway in PIP2 Opening Kir Channels.Phosphoinositide control of membrane protein function: a frontier led by studies on ion channels.Mutations in Nature Conferred a High Affinity Phosphatidylinositol 4,5-Bisphosphate-binding Site in Vertebrate Inwardly Rectifying Potassium ChannelsMolecular overlap in the regulation of SK channels by small molecules and phosphoinositidesA Critical Gating Switch at a Modulatory Site in Neuronal Kir3 ChannelsThe cytosolic GH loop regulates the phosphatidylinositol 4,5-bisphosphate-induced gating kinetics of Kir2 channels.The Molecular Mechanism of Opening the Helix Bundle Crossing (HBC) Gate of a Kir Channel.Conformational changes underlying pore dilation in the cytoplasmic domain of mammalian inward rectifier K+ channels.Identification of novel cholesterol-binding regions in Kir2 channels.Structural Basis for Differences in Dynamics Induced by Leu Versus Ile Residues in the CD Loop of Kir ChannelsThe ICl,swell inhibitor DCPIB blocks Kir channels that possess weak affinity for PIP2.Cholesterol sensitivity of KIR2.1 depends on functional inter-links between the N and C termini.Competition of calcified calmodulin N lobe and PIP2 to an LQT mutation site in Kv7.1 channel.Three pairs of weak interactions precisely regulate the G-loop gate of Kir2.1 channel.Simulation-based prediction of phosphatidylinositol 4,5-bisphosphate binding to an ion channel.Molecular Dynamics Simulations of KirBac1.1 Mutants Reveal Global Gating Changes of Kir Channels.Insights into the structural nature of the transition state in the Kir channel gating pathway.Dynamic role of the tether helix in PIP2-dependent gating of a G protein-gated potassium channelA computational model predicts that Gβγ acts at a cleft between channel subunits to activate GIRK1 channels.Exploring the mechanism how Marburg virus VP35 recognizes and binds dsRNA by molecular dynamics simulations and free energy calculations.Structural basis for the ethanol action on G-protein-activated inwardly rectifying potassium channel 1 revealed by NMR spectroscopy.
P2860
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P2860
The molecular mechanism by which PIP(2) opens the intracellular G-loop gate of a Kir3.1 channel.
description
2012 nî lūn-bûn
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2012年の論文
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2012年論文
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2012年論文
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2012年論文
@zh-hk
2012年論文
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2012年論文
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2012年论文
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name
The molecular mechanism by whi ...... loop gate of a Kir3.1 channel.
@ast
The molecular mechanism by whi ...... loop gate of a Kir3.1 channel.
@en
type
label
The molecular mechanism by whi ...... loop gate of a Kir3.1 channel.
@ast
The molecular mechanism by whi ...... loop gate of a Kir3.1 channel.
@en
prefLabel
The molecular mechanism by whi ...... loop gate of a Kir3.1 channel.
@ast
The molecular mechanism by whi ...... loop gate of a Kir3.1 channel.
@en
P2093
P2860
P1433
P1476
The molecular mechanism by whi ...... loop gate of a Kir3.1 channel.
@en
P2093
Diomedes E Logothetis
Hong-Xing Zhang
Xuan-Yu Meng
P2860
P304
P356
10.1016/J.BPJ.2012.03.050
P407
P577
2012-05-01T00:00:00Z