Extensive methylation of promoter sequences silences lentiviral transgene expression during stem cell differentiation in vivo.
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Post-transcriptional gene silencing, transcriptional gene silencing and human immunodeficiency virusBioluminescent imaging of genetically selected induced pluripotent stem cell-derived cardiomyocytes after transplantation into infarcted heart of syngeneic recipientsLent-On-Plus Lentiviral vectors for conditional expression in human stem cellsThe Clonal Fate of Live Cells.Gene therapy using stem cellsNext-generation libraries for robust RNA interference-based genome-wide screens.Reporter Gene Silencing in Targeted Mouse Mutants Is Associated with Promoter CpG Island Methylation.Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene ExpressionEvaluating the use of a CpG free promoter for long-term recombinant protein expression stability in Chinese hamster ovary cells.An assessment of the effects of ectopic gp91phox expression in XCGD iPSC-derived neutrophils.Engraftment potential of adipose tissue-derived human mesenchymal stem cells after transplantation in the fetal rabbitGeneration of transgenic cynomolgus monkeys that express green fluorescent protein throughout the whole bodyGenetic and epigenetic variants contributing to clofarabine cytotoxicity.A chimeric HS4-SAR insulator (IS2) that prevents silencing and enhances expression of lentiviral vectors in pluripotent stem cells.Optimized inducible shRNA and CRISPR/Cas9 platforms for in vitro studies of human development using hPSCs.Experimental design for stable genetic manipulation in mammalian cell lines: lentivirus and alternatives.The CpG-sites of the CBX3 ubiquitous chromatin opening element are critical structural determinants for the anti-silencing function.A minimal ubiquitous chromatin opening element (UCOE) effectively prevents silencing of juxtaposed heterologous promoters by epigenetic remodeling in multipotent and pluripotent stem cells.Detailed comparison of retroviral vectors and promoter configurations for stable and high transgene expression in human induced pluripotent stem cells.Lentivirus-meditated frataxin gene delivery reverses genome instability in Friedreich ataxia patient and mouse model fibroblastsImaging grafted cells with [18F]FHBG using an optimized HSV1-TK mammalian expression vector in a brain injury rodent model.Prolonged expansion of human nucleus pulposus cells expressing human telomerase reverse transcriptase mediated by lentiviral vector.TALEN-mediated functional correction of human iPSC-derived macrophages in context of hereditary pulmonary alveolar proteinosis.Exposure to hypomethylating agent, 5-azacytidine, may improve iCasp9 suicide gene therapy for treating GvHD in allografts.Production of transgenic pigs using the pGFAP-CreERT2;EGFPLoxP inducible system for central nervous system disease models.F2A sequence linking MGMT(P140K) and MDR1 in a bicistronic lentiviral vector enables efficient chemoprotection of haematopoietic stem cells.
P2860
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P2860
Extensive methylation of promoter sequences silences lentiviral transgene expression during stem cell differentiation in vivo.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Extensive methylation of promo ...... cell differentiation in vivo.
@ast
Extensive methylation of promo ...... cell differentiation in vivo.
@en
type
label
Extensive methylation of promo ...... cell differentiation in vivo.
@ast
Extensive methylation of promo ...... cell differentiation in vivo.
@en
prefLabel
Extensive methylation of promo ...... cell differentiation in vivo.
@ast
Extensive methylation of promo ...... cell differentiation in vivo.
@en
P2093
P2860
P50
P356
P1433
P1476
Extensive methylation of promo ...... cell differentiation in vivo.
@en
P2093
Ali Nowrouzi
Franciscus van der Hoeven
Frank Lyko
Friederike Herbst
Hanno Glimm
Manfred Schmidt
Oksana Zavidij
Sylvia Fessler
Ulrich Kloz
P2860
P304
P356
10.1038/MT.2012.46
P577
2012-03-20T00:00:00Z