The chaperone-assisted E3 ligase C terminus of Hsc70-interacting protein (CHIP) targets PTEN for proteasomal degradation. - Wikidata - awgldk - TriplyDB

The chaperone-assisted E3 ligase C terminus of Hsc70-interacting protein (CHIP) targets PTEN for proteasomal degradation.

The chaperone-assisted E3 ligase C terminus of Hsc70-interacting protein (CHIP) targets PTEN for proteasomal degradation.

http://www.wikidata.org/entity/Q35939892

about

HAUSP, a novel deubiquitinase for Rb - MDM2 the critical regulator CHIP: A new modulator of human malignant disorders Regulation of Bim in Health and Disease Focus on PTEN Regulation A Decade of Boon or Burden: What Has the CHIP Ever Done for Cellular Protein Quality Control Mechanism Implicated in Neurodegeneration and Aging?Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis CHIP has a protective role against oxidative stress-induced cell death through specific regulation of endonuclease G 2,2'-diphenyl-3,3'-diindolylmethane: a potent compound induces apoptosis in breast cancer cells by inhibiting EGFR pathway CHIP regulates AKT/FoxO/Bim signaling in MCF7 and MCF10A cells The E3 Ligase CHIP Mediates p21 Degradation to Maintain Radioresistance.Exosome-mediated delivery of the intrinsic C-terminus domain of PTEN protects it from proteasomal degradation and ablates tumorigenesis GSK3β controls epithelial-mesenchymal transition and tumor metastasis by CHIP-mediated degradation of Slug CHIP is a novel tumor suppressor in pancreatic cancer through targeting EGFR Pathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseases Ubiquitination of inositol-requiring enzyme 1 (IRE1) by the E3 ligase CHIP mediates the IRE1/TRAF2/JNK pathway.Ubiquitin E3 ligase Nedd4-1 acts as a downstream target of PI3K/PTEN-mTORC1 signaling to promote neurite growth.Pharmacological targeting of the pseudokinase Her3 Roles of ubiquitination and SUMOylation on prostate cancer: mechanisms and clinical implications.Carboxyl terminus of HSC70-interacting protein (CHIP) down-regulates NF-κB-inducing kinase (NIK) and suppresses NIK-induced liver injury miR-1236 down-regulates alpha-fetoprotein, thus causing PTEN accumulation, which inhibits the PI3K/Akt pathway and malignant phenotype in hepatoma cells PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis CHIP stabilizes amyloid precursor protein via proteasomal degradation and p53-mediated trans-repression of β-secretase.WWP2 and its association with PTEN in endometrial cancer MicroRNAs and Glucocorticoid-Induced Apoptosis in Lymphoid Malignancies Downregulation of Hsp27 (HSPB1) in MCF-7 human breast cancer cells induces upregulation of PTEN.Human cytomegalovirus inhibits apoptosis by proteasome-mediated degradation of Bax at endoplasmic reticulum-mitochondrion contacts Prognostic value of the ubiquitin ligase carboxyl terminus of the Hsc70-interacting protein in postmenopausal breast cancer.ΔNp63α represses nuclear translocation of PTEN by inhibition of NEDD4-1 in keratinocytes.C-terminus of HSC70-Interacting Protein (CHIP) Inhibits Adipocyte Differentiation via Ubiquitin- and Proteasome-Mediated Degradation of PPARγ.PIASxα ligase enhances SUMO1 modification of PTEN protein as a SUMO E3 ligase.Deubiquitylation and stabilization of PTEN by USP13 DJ-1 maintains energy and glucose homeostasis by regulating the function of brown adipose tissue.The E3 ubiquitin ligase CHIP/miR-92b/PTEN regulatory network contributes to tumorigenesis of glioblastoma.Cancer stem-like cell related protein CD166 degrades through E3 ubiquitin ligase CHIP in head and neck cancer.Stability of the cancer target DDIAS is regulated by the CHIP/HSP70 pathway in lung cancer cells.Mechanisms of proteasome inhibitor-induced cytotoxicity in malignant glioma.PTEN function: the long and the short of it.Controlling PTEN (Phosphatase and Tensin Homolog) Stability: A DOMINANT ROLE FOR LYSINE 66.CHIP controls necroptosis through ubiquitylation- and lysosome-dependent degradation of RIPK3.BAG5 regulates PTEN stability in MCF-7 cell line

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The chaperone-assisted E3 ligase C terminus of Hsc70-interacting protein (CHIP) targets PTEN for proteasomal degradation.

http://www.wikidata.org/entity/Q35939892

description

2012 nî lūn-bûn

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2012年の論文

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年學術文章

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2012年學術文章

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2012年學術文章

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name

The chaperone-assisted E3 liga ...... N for proteasomal degradation.

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The chaperone-assisted E3 liga ...... N for proteasomal degradation.

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type

label

The chaperone-assisted E3 liga ...... N for proteasomal degradation.

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The chaperone-assisted E3 liga ...... N for proteasomal degradation.

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The chaperone-assisted E3 liga ...... N for proteasomal degradation.

@ast

The chaperone-assisted E3 liga ...... N for proteasomal degradation.

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JBC.M111.321083

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Journal of Biological Chemistry

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The chaperone-assisted E3 liga ...... N for proteasomal degradation.

@en

P2093

Anirban Chatterjee

http://www.w3.org/2001/XMLSchema#string

Indranil Paul

http://www.w3.org/2001/XMLSchema#string

Mrinal K Ghosh

http://www.w3.org/2001/XMLSchema#string

Satamita Deb

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Syed Feroj Ahmed

http://www.w3.org/2001/XMLSchema#string

Tapashi Mandal

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Uttara Chatterjee

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P2860

Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions.

The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins

U box proteins as a new family of ubiquitin-protein ligases

NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN

Ubiquitination regulates PTEN nuclear import and tumor suppression

X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization

Mdm2 promotes the rapid degradation of p53

The cochaperone HspBP1 inhibits the CHIP ubiquitin ligase and stimulates the maturation of the cystic fibrosis transmembrane conductance regulator

Docking-dependent ubiquitination of the interferon regulatory factor-1 tumor suppressor protein by the ubiquitin ligase CHIP

The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization

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15996-16006

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10.1074/JBC.M111.321083

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19

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287

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221716080

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22427670

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P921

molecular chaperones

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3346122

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