Development and characterization of recombinant human Fc:OX40L fusion protein linked via a coiled-coil trimerization domain
about
Activity of soluble OX40 ligand is enhanced by oligomerization and cell surface immobilizationPrinciples of antibody-mediated TNF receptor activationImmunotherapy in the treatment of non-small cell lung cancerScience gone translational: the OX40 agonist storyFully recombinant IgG2a Fc multimers (stradomers) effectively treat collagen-induced arthritis and prevent idiopathic thrombocytopenic purpura in miceCaloric restriction maintains OX40 agonist-mediated tumor immunity and CD4 T cell priming during aging.Control of immunity by the TNFR-related molecule OX40 (CD134)OX40 is a potent immune-stimulating target in late-stage cancer patients.Assembling OX40 aptamers on a molecular scaffold to create a receptor-activating aptamer.Enforced covalent trimerisation of soluble feline CD134 (OX40)-ligand generates a functional antagonist of feline immunodeficiency virus.The role of TNF superfamily members in T-cell function and diseases.Integrating costimulatory agonists to optimize immune-based cancer therapies.Costimulatory and coinhibitory receptors in anti-tumor immunitySignaling through OX40 enhances antitumor immunity.T cell co-stimulatory molecules: a co-conspirator in the pathogenesis of eosinophilic esophagitis?Novel antibodies targeting immune regulatory checkpoints for cancer therapy.Targeting of the tumor necrosis factor receptor superfamily for cancer immunotherapy.Targeting tumor-necrosis factor receptor pathways for tumor immunotherapyOX40, OX40L and Autoimmunity: a Comprehensive Review.Delivering safer immunotherapies for cancer.Fc Engineering Approaches to Enhance the Agonism and Effector Functions of an Anti-OX40 Antibody.Immunosilencing a highly immunogenic protein trimerization domain.Combination therapy with an OX40L fusion protein and a vaccine targeting the transcription factor twist inhibits metastasis in a murine model of breast cancer.Potent Immune Modulation by MEDI6383, an Engineered Human OX40 Ligand IgG4P Fc Fusion Protein.
P2860
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P2860
Development and characterization of recombinant human Fc:OX40L fusion protein linked via a coiled-coil trimerization domain
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Development and characterizati ...... iled-coil trimerization domain
@ast
Development and characterizati ...... iled-coil trimerization domain
@en
type
label
Development and characterizati ...... iled-coil trimerization domain
@ast
Development and characterizati ...... iled-coil trimerization domain
@en
prefLabel
Development and characterizati ...... iled-coil trimerization domain
@ast
Development and characterizati ...... iled-coil trimerization domain
@en
P2093
P2860
P1433
P1476
Development and characterizati ...... iled-coil trimerization domain
@en
P2093
Andrew D Weinberg
Brendan D Curti
Carmen Peters
Hong-Ming Hu
Nicholas P Morris
Ryan Montler
Walter J Urba
P2860
P304
P356
10.1016/J.MOLIMM.2007.02.004
P577
2007-03-19T00:00:00Z