Combinatorial protein engineering of proteolytically resistant mesotrypsin inhibitors as candidates for cancer therapy
about
An Acrobatic Substrate Metamorphosis Reveals a Requirement for Substrate Conformational Dynamics in Trypsin Proteolysis.Small molecule inhibitors of mesotrypsin from a structure-based docking screen.A Camelid-derived Antibody Fragment Targeting the Active Site of a Serine Protease Balances between Inhibitor and Substrate Behavior.A computational combinatorial approach identifies a protein inhibitor of superoxide dismutase 1 misfolding, aggregation, and cytotoxicity.Pre-equilibrium competitive library screening for tuning inhibitor association rate and specificity toward serine proteases.Converting a broad matrix metalloproteinase family inhibitor into a specific inhibitor of MMP-9 and MMP-14.A potent, proteolysis-resistant inhibitor of kallikrein-related peptidase 6 (KLK6) for cancer therapy, developed by combinatorial engineeringCombinatorial engineering of N-TIMP2 variants that selectively inhibit MMP9 and MMP14 function in the cellMapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries
P2860
Q30394859-14051702-37AB-4AF8-BCFF-BEEA66D88C37Q33626452-19F149F2-01CC-42ED-AF8A-6903344B2BA3Q37098934-1AA28BE0-2696-4398-827B-F12458297549Q47741777-00A41925-2345-480A-A3E6-092B1D923EB4Q52657347-6660276F-60D0-48E0-A94B-086CF647526EQ52688539-9F0028D7-78F6-458D-B281-28DBF9C83D4DQ56888917-E6288717-EEF5-401C-8355-093B6B3ABA09Q56889045-F4F4584F-8C90-4688-B3C9-4A8FB467D6F9Q58695396-EAA68ABA-7B22-4CB7-8C1A-6C06DB22A4CF
P2860
Combinatorial protein engineering of proteolytically resistant mesotrypsin inhibitors as candidates for cancer therapy
description
2016 nî lūn-bûn
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2016年の論文
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2016年学术文章
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2016年学术文章
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2016年学术文章
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2016年学术文章
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2016年学术文章
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2016年學術文章
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2016年學術文章
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name
Combinatorial protein engineer ...... candidates for cancer therapy
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Combinatorial protein engineer ...... candidates for cancer therapy
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type
label
Combinatorial protein engineer ...... candidates for cancer therapy
@ast
Combinatorial protein engineer ...... candidates for cancer therapy
@en
prefLabel
Combinatorial protein engineer ...... candidates for cancer therapy
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Combinatorial protein engineer ...... candidates for cancer therapy
@en
P2093
P2860
P356
P1433
P1476
Combinatorial protein engineer ...... candidates for cancer therapy
@en
P2093
Alexandra Hockla
Banumathi Sankaran
Derek C Radisky
Evette S Radisky
Itay Cohen
Olumide Kayode
P2860
P304
P356
10.1042/BJ20151410
P407
P577
2016-03-08T00:00:00Z