An engineered lantibiotic synthetase that does not require a leader peptide on its substrate.
about
Lanthipeptides: chemical synthesis versus in vivo biosynthesis as tools for pharmaceutical productionStructural basis for precursor protein-directed ribosomal peptide macrocyclizationBacteriocins of lactic acid bacteria: extending the familyRibosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature.When the leader gets loose: in vivo biosynthesis of a leaderless prenisin is stimulated by a trans-acting leader peptide.Identification of an Auxiliary Leader Peptide-Binding Protein Required for Azoline Formation in Ribosomal Natural Products.Structural analysis of leader peptide binding enables leader-free cyanobactin processingA price to pay for relaxed substrate specificity: a comparative kinetic analysis of the class II lanthipeptide synthetases ProcM and HalM2.Recognition sequences and substrate evolution in cyanobactin biosynthesisSynergistic binding of the leader and core peptides by the lantibiotic synthetase HalM2.Facile Removal of Leader Peptides from Lanthipeptides by Incorporation of a Hydroxy AcidCombinatorial biosynthesis of RiPPs: docking with marine life.Leader Peptide-Free In Vitro Reconstitution of Microviridin Biosynthesis Enables Design of Synthetic Protease-Targeted Libraries.Biosynthesis of the class III lantipeptide catenulipeptinAutocatalytic backbone N-methylation in a family of ribosomal peptide natural products.Non-proteinogenic amino acids in lacticin 481 analogues result in more potent inhibition of peptidoglycan transglycosylation.New Insights into the Biosynthetic Logic of Ribosomally Synthesized and Post-translationally Modified Peptide Natural Products.Leader Peptide Establishes Dehydration Order, Promotes Efficiency, and Ensures Fidelity During Lacticin 481 Biosynthesis.Insights into the mechanism of peptide cyclodehydrations achieved through the chemoenzymatic generation of amide derivatives.Chemical synthesis of the lantibiotic lacticin 481 reveals the importance of lanthionine stereochemistry.A general method for fluorescent labeling of the N-termini of lanthipeptides and its application to visualize their cellular localization.Ribosomally synthesized and post-translationally modified peptide natural products: new insights into the role of leader and core peptides during biosynthesis.One-pot synthesis of class II lanthipeptide bovicin HJ50 via an engineered lanthipeptide synthetase.Advances in the arsenal of tools available enabling the discovery of novel lantibiotics with therapeutic potential.YcaO-Dependent Posttranslational Amide Activation: Biosynthesis, Structure, and Function.Employing the promiscuity of lantibiotic biosynthetic machineries to produce novel antimicrobials.Mechanisms of cyanobactin biosynthesisMechanistic Understanding of Lanthipeptide Biosynthetic Enzymes.Natural product analogues: towards a blueprint for analogue-focused synthesis.Biosynthetic Pathway Connects Cryptic Ribosomally Synthesized Posttranslationally Modified Peptide Genes with Pyrroloquinoline Alkaloids.Enzymatic N- and C-Protection in Cyanobactin RiPP Natural Products.Incorporation of Nonproteinogenic Amino Acids in Class I and II Lantibiotics.A distributive peptide cyclase processes multiple microviridin core peptides within a single polypeptide substrate.
P2860
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P2860
An engineered lantibiotic synthetase that does not require a leader peptide on its substrate.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
An engineered lantibiotic synt ...... ader peptide on its substrate.
@ast
An engineered lantibiotic synt ...... ader peptide on its substrate.
@en
type
label
An engineered lantibiotic synt ...... ader peptide on its substrate.
@ast
An engineered lantibiotic synt ...... ader peptide on its substrate.
@en
prefLabel
An engineered lantibiotic synt ...... ader peptide on its substrate.
@ast
An engineered lantibiotic synt ...... ader peptide on its substrate.
@en
P2093
P2860
P356
P1476
An engineered lantibiotic synt ...... ader peptide on its substrate.
@en
P2093
Juan E Velásquez
Noah A Bindman
Patrick J Knerr
Trent J Oman
Wilfred A van der Donk
P2860
P304
P356
10.1021/JA3017297
P407
P577
2012-04-11T00:00:00Z