RECQL4 localizes to mitochondria and preserves mitochondrial DNA integrity - Wikidata - awgldk - TriplyDB

RECQL4 localizes to mitochondria and preserves mitochondrial DNA integrity

RECQL4 localizes to mitochondria and preserves mitochondrial DNA integrity

http://www.wikidata.org/entity/Q35953917

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Hallmarks of progeroid syndromes: lessons from mice and reprogrammed cells RECQL4 in genomic instability and aging Roles of DNA helicases in the maintenance of genome integrity Mitochondrial DNA damage and its consequences for mitochondrial gene expression Differential Protein Distribution between the Nucleus and Mitochondria: Implications in Aging Nuclear DNA damage signalling to mitochondria in ageing Novel subcellular localization of the DNA helicase Twinkle at the kinetochore complex during mitosis in neuronal-like progenitor cells.Mitochondrial DNA replication: a PrimPol perspective.Oxidative stress and mitochondrial dysfunction across broad-ranging pathologies: toward mitochondria-targeted clinical strategies.Impaired p32 regulation caused by the lymphoma-prone RECQ4 mutation drives mitochondrial dysfunction.Senescence induced by RECQL4 dysfunction contributes to Rothmund-Thomson syndrome features in mice.Association of G-quadruplex forming sequences with human mtDNA deletion breakpoints.The intrinsically disordered amino-terminal region of human RecQL4: multiple DNA-binding domains confer annealing, strand exchange and G4 DNA binding.Borrowing nuclear DNA helicases to protect mitochondrial DNA."...Rewritten in the skin": clues to skin biology and aging from inherited disease.DNA helicases associated with genetic instability, cancer, and aging.Human RecQ helicases in DNA repair, recombination, and replication.RecQL4 cytoplasmic localization: implications in mitochondrial DNA oxidative damage repair.RAPADILINO RECQL4 mutant protein lacks helicase and ATPase activity Interaction of RECQ4 and MCM10 is important for efficient DNA replication origin firing in human cells.p53 as guardian of the mitochondrial genome Rothmund-Thomson Syndrome: novel pathogenic mutations and frequencies of variants in the RECQL4 and USB1 (C16orf57) gene.Mitochondria as a target of environmental toxicants.Mitochondrial dysfunction: a neglected component of skin diseases.Mitochondrial DNA maintenance: an appraisal.DNA Damage, DNA Repair, Aging, and Neurodegeneration Mechanistic and biological considerations of oxidatively damaged DNA for helicase-dependent pathways of nucleic acid metabolism.Role of mitochondrial DNA damage and dysfunction in veterans with Gulf War Illness.Yeast Hrq1 shares structural and functional homology with the disease-linked human RecQ4 helicase.The human mitochondrial transcription factor A is a versatile G-quadruplex binding protein.Irc3 is a mitochondrial DNA branch migration enzyme Mitochondrial DNA repair: a novel therapeutic target for heart failure.RECQL4 and p53 potentiate the activity of polymerase γ and maintain the integrity of the human mitochondrial genome.RecQ and Fe-S helicases have unique roles in DNA metabolism dictated by their unwinding directionality, substrate specificity, and protein interactions.RECQL4 Regulates p53 Function In Vivo During Skeletogenesis.Overexpression of RECQL4 is associated with poor prognosis in patients with gastric cancer

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P2860

RECQL4 localizes to mitochondria and preserves mitochondrial DNA integrity

http://www.wikidata.org/entity/Q35953917

description

2012 nî lūn-bûn

@nan

2012年の論文

@ja

2012年論文

@yue

2012年論文

@zh-hant

2012年論文

@zh-hk

2012年論文

@zh-mo

2012年論文

@zh-tw

2012年论文

@wuu

2012年论文

@zh

2012年论文

@zh-cn

name

RECQL4 localizes to mitochondria and preserves mitochondrial DNA integrity

@ast

RECQL4 localizes to mitochondria and preserves mitochondrial DNA integrity

@en

type

label

RECQL4 localizes to mitochondria and preserves mitochondrial DNA integrity

@ast

RECQL4 localizes to mitochondria and preserves mitochondrial DNA integrity

@en

prefLabel

RECQL4 localizes to mitochondria and preserves mitochondrial DNA integrity

@ast

RECQL4 localizes to mitochondria and preserves mitochondrial DNA integrity

@en

P1433

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P356

J.1474-9726.2012.00803.X

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P1476

RECQL4 localizes to mitochondria and preserves mitochondrial DNA integrity

@en

P2093

Chandrika Canugovi

http://www.w3.org/2001/XMLSchema#string

Deborah L Croteau

http://www.w3.org/2001/XMLSchema#string

Dharmendra Kumar Singh

http://www.w3.org/2001/XMLSchema#string

Jane Tian

http://www.w3.org/2001/XMLSchema#string

Marie L Rossi

http://www.w3.org/2001/XMLSchema#string

Peter Sykora

http://www.w3.org/2001/XMLSchema#string

Rajesh Kasiviswanathan

http://www.w3.org/2001/XMLSchema#string

Vilhelm A Bohr

http://www.w3.org/2001/XMLSchema#string

Zheng Ming Wang

http://www.w3.org/2001/XMLSchema#string

P2860

Rothmund-Thomson syndrome

The mitochondrial p55 accessory subunit of human DNA polymerase gamma enhances DNA binding, promotes processive DNA synthesis, and confers N-ethylmaleimide resistance

Dual DNA unwinding activities of the Rothmund-Thomson syndrome protein, RECQ4

RECQL4, mutated in the Rothmund-Thomson and RAPADILINO syndromes, interacts with ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway

RECQL4, the protein mutated in Rothmund-Thomson syndrome, functions in telomere maintenance

Identification of 5'-deoxyribose phosphate lyase activity in human DNA polymerase gamma and its role in mitochondrial base excision repair in vitro.

Autosomal recessive cerebellar ataxias.

Initiation of DNA replication requires the RECQL4 protein mutated in Rothmund-Thomson syndrome.

The involvement of human RECQL4 in DNA double-strand break repair.

Human RECQ1 and RECQ4 helicases play distinct roles in DNA replication initiation

P304

456-466

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scholarly article

P356

10.1111/J.1474-9726.2012.00803.X

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P433

3

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P478

11

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P50

Mahesh Ramamoorthy

William C Copeland

P577

2012-03-02T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

221797660

http://www.w3.org/2001/XMLSchema#string

P698

22296597

http://www.w3.org/2001/XMLSchema#string

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mitochondrial DNA

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3350572

http://www.w3.org/2001/XMLSchema#string