Techniques: Use of concatenated subunits for the study of ligand-gated ion channels.
about
The benzodiazepine binding site of GABA A receptors as a target for the development of novel anxiolyticsSWELL1, a plasma membrane protein, is an essential component of volume-regulated anion channelTMEM16A(a)/anoctamin-1 shares a homodimeric architecture with CLC chloride channelsNeurosteroids: endogenous regulators of the GABA(A) receptorSubunit dimers of alpha-hemolysin expand the engineering toolbox for protein nanoporesThe leukocidin pore: evidence for an octamer with four LukF subunits and four LukS subunits alternating around a central axis.Separation of heteromeric potassium channel Kcv towards probing subunit composition-regulated ion permeation and gating.Diversity of structure and function of alpha1alpha6beta3delta GABAA receptors: comparison with alpha1beta3delta and alpha6beta3delta receptorsThe major central endocannabinoid directly acts at GABA(A) receptors.GABA(A) receptor subtype-selective efficacy: TPA023, an alpha2/alpha3 selective non-sedating anxiolytic and alpha5IA, an alpha5 selective cognition enhancer.In glycine and GABA(A) channels, different subunits contribute asymmetrically to channel conductance via residues in the extracellular domain.Use of concatemers of ligand-gated ion channel subunits to study mechanisms of steroid potentiation.Alpha subunit position and GABA receptor function.Stoichiometry of the human glycine receptor revealed by direct subunit counting.Estimating the efficiency of benzodiazepines on GABA(A) receptors comprising gamma1 or gamma2 subunits.Tandem couture: Cys-loop receptor concatamer insights and caveats.Tandem subunits effectively constrain GABAA receptor stoichiometry and recapitulate receptor kinetics but are insensitive to GABAA receptor-associated protein.Etomidate produces similar allosteric modulation in α1β3δ and α1β3γ2L GABA(A) receptors.Stoichiometry of altered hERG1 channel gating by small molecule activatorsStudying macromolecular complex stoichiometries by peptide-based mass spectrometryThe molecular architecture of the arachidonate-regulated Ca2+-selective ARC channel is a pentameric assembly of Orai1 and Orai3 subunits.Toward Understanding Functional Properties and Subunit Arrangement of α4β2δ γ-Aminobutyric Acid, Type A (GABAA) Receptors.Comparison of γ-Aminobutyric Acid, Type A (GABAA), Receptor αβγ and αβδ Expression Using Flow Cytometry and Electrophysiology: EVIDENCE FOR ALTERNATIVE SUBUNIT STOICHIOMETRIES AND ARRANGEMENTSUnanticipated structural and functional properties of delta-subunit-containing GABAA receptors.How to validate a heteromeric ion channel drug target: assessing proper expression of concatenated subunits.Consequence of the presence of two different beta subunit isoforms in a GABA(A) receptor.A GABA(A) receptor of defined subunit composition and positioning: concatenation of five subunits.GABA type a receptor trafficking and the architecture of synaptic inhibition.
P2860
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P2860
Techniques: Use of concatenated subunits for the study of ligand-gated ion channels.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Techniques: Use of concatenated subunits for the study of ligand-gated ion channels.
@ast
Techniques: Use of concatenated subunits for the study of ligand-gated ion channels.
@en
type
label
Techniques: Use of concatenated subunits for the study of ligand-gated ion channels.
@ast
Techniques: Use of concatenated subunits for the study of ligand-gated ion channels.
@en
prefLabel
Techniques: Use of concatenated subunits for the study of ligand-gated ion channels.
@ast
Techniques: Use of concatenated subunits for the study of ligand-gated ion channels.
@en
P1476
Techniques: Use of concatenated subunits for the study of ligand-gated ion channels
@en
P2093
Erwin Sigel
P304
P356
10.1016/J.TIPS.2004.07.005
P577
2004-09-01T00:00:00Z