Pharmacological Selectivity Within Class I Histone Deacetylases Predicts Effects on Synaptic Function and Memory Rescue. - Wikidata - awgldk - TriplyDB

Pharmacological Selectivity Within Class I Histone Deacetylases Predicts Effects on Synaptic Function and Memory Rescue.

Pharmacological Selectivity Within Class I Histone Deacetylases Predicts Effects on Synaptic Function and Memory Rescue.

http://www.wikidata.org/entity/Q35960375

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Sensory Cortical Plasticity Participates in the Epigenetic Regulation of Robust Memory Formation.Epigenetic Alterations in Alzheimer's Disease Histone Deacetylase (HDAC) Inhibitors - emerging roles in neuronal memory, learning, synaptic plasticity and neural regeneration Histone Deacetylase Inhibition via RGFP966 Releases the Brakes on Sensory Cortical Plasticity and the Specificity of Memory Formation The development prospection of HDAC inhibitors as a potential therapeutic direction in Alzheimer's disease.Insights into neuroepigenetics through human histone deacetylase PET imaging.The Effects of Pharmacological Inhibition of Histone Deacetylase 3 (HDAC3) in Huntington's Disease Mice.Concomitant histone deacetylase and phosphodiesterase 5 inhibition synergistically prevents the disruption in synaptic plasticity and it reverses cognitive impairment in a mouse model of Alzheimer's disease.Why Hydroxamates May Not Be the Best Histone Deacetylase Inhibitors--What Some May Have Forgotten or Would Rather Forget?Susceptibility and Resilience to Posttraumatic Stress Disorder-like Behaviors in Inbred Mice.Functional analyses of major cancer-related signaling pathways in Alzheimer's disease etiology.Development of Allosteric Hydrazide-Containing Class I Histone Deacetylase Inhibitors for Use in Acute Myeloid Leukemia.Distinct roles for the deacetylase domain of HDAC3 in the hippocampus and medial prefrontal cortex in the formation and extinction of memory.Context and Auditory Fear are Differentially Regulated by HDAC3 Activity in the Lateral and Basal Subnuclei of the Amygdala.HDAC3 negatively regulates spatial memory in a mouse model of Alzheimer's disease.M344 promotes nonamyloidogenic amyloid precursor protein processing while normalizing Alzheimer's disease genes and improving memory.A First-in-Class Small-Molecule that Acts as a Dual Inhibitor of HDAC and PDE5 and that Rescues Hippocampal Synaptic Impairment in Alzheimer's Disease Mice.Inhibition of Histone Deacetylase 3 Restores Amyloid-β Oligomer-Induced Plasticity Deficit in Hippocampal CA1 Pyramidal Neurons.Deleting HDAC3 rescues long-term memory impairments induced by disruption of the neuron-specific chromatin remodeling subunit BAF53b.Inhibition of HDAC3 prevents diabetic cardiomyopathy in OVE26 mice via epigenetic regulation of DUSP5-ERK1/2 pathway.Into the Fourth Dimension: Dysregulation of Genome Architecture in Aging and Alzheimer's Disease.Improved Scalability of Neuron-Based Phenotypic Screening Assays for Therapeutic Discovery in Neuropsychiatric Disorders.Habits Are Negatively Regulated by Histone Deacetylase 3 in the Dorsal Striatum.GABAergic inhibitory neurons as therapeutic targets for cognitive impairment in schizophrenia.Histone Deacetylase Inhibitor Alleviates the Neurodegenerative Phenotypes and Histone Dysregulation in Presenilins-Deficient Mice.

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Pharmacological Selectivity Within Class I Histone Deacetylases Predicts Effects on Synaptic Function and Memory Rescue.

http://www.wikidata.org/entity/Q35960375

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2015 nî lūn-bûn

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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Pharmacological Selectivity Wi ...... ic Function and Memory Rescue.

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Pharmacological Selectivity Wi ...... ic Function and Memory Rescue.

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Pharmacological Selectivity Wi ...... ic Function and Memory Rescue.

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Neuropsychopharmacology

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Pharmacological Selectivity Wi ...... tic Function and Memory Rescue

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Camilo S Rojas

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Christopher R Hubbs

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Emin D Ozkan

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Gavin Rumbaugh

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James Rusche

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Mark Kilgore

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Sathyanarayanan V Puthanveettil

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Shashi Kudugunti

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Stephanie E Sillivan

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HDAC2 negatively regulates memory formation and synaptic plasticity.

An epigenetic blockade of cognitive functions in the neurodegenerating brain

The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice.

HDAC inhibitors correct frataxin deficiency in a Friedreich ataxia mouse model

Spines, plasticity, and cognition in Alzheimer's model mice

Histone deacetylases 1 and 2 are expressed at distinct stages of neuro-glial development

Inhibition of histone deacetylase 3 causes replication stress in cutaneous T cell lymphoma

Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment

Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP

Recovery of learning and memory is associated with chromatin remodelling

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2307-2316

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10.1038/NPP.2015.93

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10

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40

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Courtney A Miller

J. David Sweatt

Massimiliano Aceti

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2015-04-03T00:00:00Z

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25837283

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4538358

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