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Excess vacuolar SNAREs drive lysis and Rab bypass fusion

Excess vacuolar SNAREs drive lysis and Rab bypass fusion

http://www.wikidata.org/entity/Q35962879

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Membrane fusion as a team effort Reconstituted membrane fusion requires regulatory lipids, SNAREs and synergistic SNARE chaperones Phosphoinositides and SNARE chaperones synergistically assemble and remodel SNARE complexes for membrane fusion HOPS prevents the disassembly of trans-SNARE complexes by Sec17p/Sec18p during membrane fusion HOPS proofreads the trans-SNARE complex for yeast vacuole fusion Yeast lipin 1 orthologue pah1p regulates vacuole homeostasis and membrane fusion.Termination of isoform-selective Vps21/Rab5 signaling at endolysosomal organelles by Msb3/Gyp3.Syntaxin 3 and SNAP-25 pairing, regulated by omega-3 docosahexaenoic acid, controls the delivery of rhodopsin for the biogenesis of cilia-derived sensory organelles, the rod outer segments In vitro assay using engineered yeast vacuoles for neuronal SNARE-mediated membrane fusion.Membranes linked by trans-SNARE complexes require lipids prone to non-bilayer structure for progression to fusion.High Transmembrane Voltage Raised by Close Contact Initiates Fusion Pore.Depolarization-evoked secretion requires two vicinal transmembrane cysteines of syntaxin 1A The yeast cell fusion protein Prm1p requires covalent dimerization to promote membrane fusion Vps-C complexes: gatekeepers of endolysosomal traffic.Osmotic regulation of Rab-mediated organelle docking HOPS initiates vacuole docking by tethering membranes before trans-SNARE complex assembly.A lipid-anchored SNARE supports membrane fusion Mitofusins and the mitochondrial permeability transition: the potential downside of mitochondrial fusion LegC3, an effector protein from Legionella pneumophila, inhibits homotypic yeast vacuole fusion in vivo and in vitro Importance of the N-terminal domain of the Qb-SNARE Vti1p for different membrane transport steps in the yeast endosomal system.In vitro reconstitution of Rab GTPase-dependent vesicle clustering by the yeast lethal giant larvae/tomosyn homolog, Sro7.Vibrio effector protein VopQ inhibits fusion of V-ATPase-containing membranes.Identification and characterization of LFD-2, a predicted fringe protein required for membrane integrity during cell fusion in neurospora crassa.Membrane fusion catalyzed by a Rab, SNAREs, and SNARE chaperones is accompanied by enhanced permeability to small molecules and by lysis.Abscisic acid prevents the coalescence of protein storage vacuoles by upregulating expression of a tonoplast intrinsic protein gene in barley aleurone.Identification of siRNA delivery enhancers by a chemical library screen.SNAREs support atlastin-mediated homotypic ER fusion in Saccharomyces cerevisiae Sec18p and Vam7p remodel trans-SNARE complexes to permit a lipid-anchored R-SNARE to support yeast vacuole fusion.A LAPF/phafin1-like protein regulates TORC1 and lysosomal membrane permeabilization in response to endoplasmic reticulum membrane stress.Class E compartments form in response to ESCRT dysfunction in yeast due to hyperactivity of the Vps21 Rab GTPase Exocytotic fusion pores are composed of both lipids and proteins.The yeast vacuolar ABC transporter Ybt1p regulates membrane fusion through Ca2+ transport modulation The lipid composition and physical properties of the yeast vacuole affect the hemifusion-fusion transition.Improved reconstitution of yeast vacuole fusion with physiological SNARE concentrations reveals an asymmetric Rab(GTP) requirement.Capture and release of partially zipped trans-SNARE complexes on intact organelles.The major role of the Rab Ypt7p in vacuole fusion is supporting HOPS membrane association.Membrane lysis during biological membrane fusion: collateral damage by misregulated fusion machines.Minimal membrane docking requirements revealed by reconstitution of Rab GTPase-dependent membrane fusion from purified components.Complex lipid requirements for SNARE- and SNARE chaperone-dependent membrane fusion.Cholesterol, regulated exocytosis and the physiological fusion machine.

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Excess vacuolar SNAREs drive lysis and Rab bypass fusion

http://www.wikidata.org/entity/Q35962879

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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2007年论文

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2007年论文

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name

Excess vacuolar SNAREs drive lysis and Rab bypass fusion

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Excess vacuolar SNAREs drive lysis and Rab bypass fusion

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type

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Excess vacuolar SNAREs drive lysis and Rab bypass fusion

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Excess vacuolar SNAREs drive lysis and Rab bypass fusion

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Excess vacuolar SNAREs drive lysis and Rab bypass fusion

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Excess vacuolar SNAREs drive lysis and Rab bypass fusion

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Proceedings of the National Academy of Sciences of the United States of America

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Excess vacuolar SNAREs drive lysis and Rab bypass fusion

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P2093

Vincent J Starai

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William Wickner

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P2860

Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells

Epsin 1 undergoes nucleocytosolic shuttling and its eps15 interactor NH(2)-terminal homology (ENTH) domain, structurally similar to Armadillo and HEAT repeats, interacts with the transcription factor promyelocytic leukemia Zn(2)+ finger protein (PLZ

Vam3p structure reveals conserved and divergent properties of syntaxins

Prm1 prevents contact-dependent lysis of yeast mating pairs.

Phox domain interaction with PtdIns(3)P targets the Vam7 t-SNARE to vacuole membranes.

Sequential action of two GTPases to promote vacuole docking and fusion

Docking of yeast vacuoles is catalyzed by the Ras-like GTPase Ypt7p after symmetric priming by Sec18p (NSF)

Purification of active HOPS complex reveals its affinities for phosphoinositides and the SNARE Vam7p.

Homotypic vacuole fusion requires Sec17p (yeast alpha-SNAP) and Sec18p (yeast NSF)

Ca2+/calmodulin signals the completion of docking and triggers a late step of vacuole fusion.

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13551-13558

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10.1073/PNAS.0704741104

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34

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104

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1959418

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