HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen. - Wikidata - awgldk - TriplyDB

HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen.

HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen.

http://www.wikidata.org/entity/Q35969973

about

Natively glycosylated HIV-1 Env structure reveals new mode for antibody recognition of the CD4-binding site Humanized Immunoglobulin Mice: Models for HIV Vaccine Testing and Studying the Broadly Neutralizing Antibody Problem.Stabilized HIV-1 envelope glycoprotein trimers for vaccine use.Mechanisms of Adaptive Immunity to Porcine Reproductive and Respiratory Syndrome Virus Neutralizing Monoclonal Antibodies to Fight HIV-1: On the Threshold of Success.Glycosylation of the core of the HIV-1 envelope subunit protein gp120 is not required for native trimer formation or viral infectivity.Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design.Diversification in the HIV-1 Envelope Hyper-variable Domains V2, V4, and V5 and Higher Probability of Transmitted/Founder Envelope Glycosylation Favor the Development of Heterologous Neutralization Breadth Experimental Estimation of the Effects of All Amino-Acid Mutations to HIV's Envelope Protein on Viral Replication in Cell Culture Antibodyomics: bioinformatics technologies for understanding B-cell immunity to HIV-1.Optimal Sequential Immunization Can Focus Antibody Responses against Diversity Loss and Distraction.Effects of partially dismantling the CD4 binding site glycan fence of HIV-1 Envelope glycoprotein trimers on neutralizing antibody induction.Exploring Human Antimicrobial Antibody Responses on a Single B Cell Level.Destabilizing an interacting motif strengthens the association of a designed ankyrin repeat protein with tubulin Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodies.SONAR: A High-Throughput Pipeline for Inferring Antibody Ontogenies from Longitudinal Sequencing of B Cell Transcripts.HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies.Structure of an N276-Dependent HIV-1 Neutralizing Antibody Targeting a Rare V5 Glycan Hole Adjacent to the CD4 Binding Site.Optimal immunization cocktails can promote induction of broadly neutralizing Abs against highly mutable pathogens.Tissue memory B cell repertoire analysis after ALVAC/AIDSVAX B/E gp120 immunization of rhesus macaques.Direct Probing of Germinal Center Responses Reveals Immunological Features and Bottlenecks for Neutralizing Antibody Responses to HIV Env Trimer.Progress toward active or passive HIV-1 vaccination.Differences in Allelic Frequency and CDRH3 Region Limit the Engagement of HIV Env Immunogens by Putative VRC01 Neutralizing Antibody Precursors.Native-like Env trimers as a platform for HIV-1 vaccine design.Ontogeny-based immunogens for the induction of V2-directed HIV broadly neutralizing antibodies.Molecular Architecture of the Cleavage-Dependent Mannose Patch on a Soluble HIV-1 Envelope Glycoprotein Trimer.Induction of HIV Neutralizing Antibody Lineages in Mice with Diverse Precursor Repertoires.Germline-targeting immunogens.Antigenic landscape of the HIV-1 envelope and new immunological concepts defined by HIV-1 broadly neutralizing antibodies.Approaches to the induction of HIV broadly neutralizing antibodies.Deep sequencing methods for protein engineering and design.Tfh cells and HIV bnAbs, an immunodominance model of the HIV neutralizing antibody generation problem.Human Ig knockin mice to study the development and regulation of HIV-1 broadly neutralizing antibodies.Antibody-virus co-evolution in HIV infection: paths for HIV vaccine development.Sequential Immunization Elicits Broadly Neutralizing Anti-HIV-1 Antibodies in Ig Knockin Mice.How germinal centers evolve broadly neutralizing antibodies: the breadth of the follicular helper T cell response.HIV-1 Cross-reactive Primary Virus Neutralizing Antibody Response Elicited by Immunization in Non-human Primate.Comprehensive Mapping of HIV-1 Escape from a Broadly Neutralizing Antibody.Global site-specific N-glycosylation analysis of HIV envelope glycoprotein.The quest for an antibody-based HIV vaccine.

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HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen.

http://www.wikidata.org/entity/Q35969973

description

2016 nî lūn-bûn

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2016年の論文

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2016年論文

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2016年論文

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2016年論文

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2016年論文

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2016年論文

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2016年论文

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2016年论文

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2016年论文

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name

HIV-1 broadly neutralizing ant ...... germline-targeting immunogen.

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HIV-1 broadly neutralizing ant ...... germline-targeting immunogen.

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type

label

HIV-1 broadly neutralizing ant ...... germline-targeting immunogen.

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HIV-1 broadly neutralizing ant ...... germline-targeting immunogen.

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prefLabel

HIV-1 broadly neutralizing ant ...... germline-targeting immunogen.

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HIV-1 broadly neutralizing ant ...... germline-targeting immunogen.

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SCIENCE.AAD9195

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HIV-1 broadly neutralizing ant ...... germline-targeting immunogen.

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Allan C deCamp

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Anita Sarkar

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Bryan Briney

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Daniel W Kulp

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Dennis R Burton

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Devin Sok

http://www.w3.org/2001/XMLSchema#string

Erik Georgeson

http://www.w3.org/2001/XMLSchema#string

Isaiah Deresa

http://www.w3.org/2001/XMLSchema#string

Joseph G Jardine

http://www.w3.org/2001/XMLSchema#string

June Ereño-Orbea

http://www.w3.org/2001/XMLSchema#string

P2860

Increasing the potency and breadth of an HIV antibody by using structure-based rational design

MolProbity: all-atom structure validation for macromolecular crystallography

PHENIX: a comprehensive Python-based system for macromolecular structure solution

Processing of X-ray diffraction data collected in oscillation mode

Antibody responses to envelope glycoproteins in HIV-1 infection

Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors

Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus

Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies

Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01

Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding

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1458-1463

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10.1126/SCIENCE.AAD9195

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6280

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351

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Jean-Philippe Julien

Colin Havenar-Daughton

Skye Macpherson

Fabian Sesterhenn

Ian Andrew Wilson

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2016-03-01T00:00:00Z

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27013733

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