The complexity of PTEN: mutation, marker and potential target for therapeutic intervention.
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Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistanceCellular prostatic acid phosphatase, a PTEN-functional homologue in prostate epithelia, functions as a prostate-specific tumor suppressorMicroRNAs in the pathobiology of sarcomasDisruption of PTEN coupling with 5-HT2C receptors suppresses behavioral responses induced by drugs of abuseMolecular fingerprinting of radiation resistant tumors: can we apprehend and rehabilitate the suspects?Targeting the translational apparatus to improve leukemia therapy: roles of the PI3K/PTEN/Akt/mTOR pathway.Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging.Involvement of Akt and mTOR in chemotherapeutic- and hormonal-based drug resistance and response to radiation in breast cancer cells.Involvement of Akt-1 and mTOR in sensitivity of breast cancer to targeted therapyCooperative effects of Akt-1 and Raf-1 on the induction of cellular senescence in doxorubicin or tamoxifen treated breast cancer cells.Radiation/paclitaxel treatment of p53-abnormal non-small cell lung cancer xenograft tumor and associated mechanism.The phosphoinositide 3-kinase signalling pathway as a therapeutic target in squamous cell carcinoma of the head and neck.The epidermal growth factor receptor gene family as a target for therapeutic intervention in numerous cancers: what's genetics got to do with it?Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia.Oxidative stress mediates radiation lung injury by inducing apoptosis.Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response.4-Methoxydalbergione suppresses growth and induces apoptosis in human osteosarcoma cells in vitro and in vivo xenograft model through down-regulation of the JAK2/STAT3 pathway.Alteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an achilles heel by sensitization to targeted therapy.Understanding signaling cascades in melanomaTargeting survival cascades induced by activation of Ras/Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways for effective leukemia therapy.Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia.Suppression of PTEN function increases breast cancer chemotherapeutic drug resistance while conferring sensitivity to mTOR inhibitors.Fish oil suppresses cell growth and metastatic potential by regulating PTEN and NF-κB signaling in colorectal cancer.Emerging MEK inhibitors.Therapeutic resistance resulting from mutations in Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways.Emerging roles of radioresistance in prostate cancer metastasis and radiation therapy.Upregulation of microrna-451 increases the sensitivity of A549 cells to radiotherapy through enhancement of apoptosis.Effect of PTEN antisense oligonucleotide on oesophageal squamous cell carcinoma cell lines.Targeting the RAF/MEK/ERK, PI3K/AKT and p53 pathways in hematopoietic drug resistance.Preclinical Remodeling of Human Prostate Cancer through the PTEN/AKT Pathway.Membrane Recruitment as a Cancer Mechanism: A Case Study of Akt PH Domain.[Expression and clinical significance of mTOR and PTEN in non-small cell lung cancer].Inhibition of PTEN expression and activity by angiotensin II induces proliferation and migration of vascular smooth muscle cells.Impaired phosphate and tension homologue deleted on chromosome 10 expression and its prognostic role in radical surgery for hepatocellular carcinoma with family aggregation resulting from hepatitis B and liver cirrhosis.Reduced proliferation of CD34(+) cells from patients with acute myeloid leukemia after gene transfer of INPP5D.Frequent elevation of Akt kinase phosphorylation in blood marrow and peripheral blood mononuclear cells from high-risk myelodysplastic syndrome patients.Pten regulates neural crest proliferation and differentiation during mouse craniofacial development.Notch signaling pathway and gene expression profiles during early in vitro differentiation of liver-derived mesenchymal stromal cells to osteoblasts.[Analysis of Efficacy of Surgical Treatment for IIIa Small Cell Lung Cancer].Extracting Fitness Relationships and Oncogenic Patterns among Driver Genes in Cancer.
P2860
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P2860
The complexity of PTEN: mutation, marker and potential target for therapeutic intervention.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
The complexity of PTEN: mutati ...... for therapeutic intervention.
@ast
The complexity of PTEN: mutati ...... for therapeutic intervention.
@en
type
label
The complexity of PTEN: mutati ...... for therapeutic intervention.
@ast
The complexity of PTEN: mutati ...... for therapeutic intervention.
@en
prefLabel
The complexity of PTEN: mutati ...... for therapeutic intervention.
@ast
The complexity of PTEN: mutati ...... for therapeutic intervention.
@en
P2093
P2860
P356
P1476
The complexity of PTEN: mutati ...... for therapeutic intervention.
@en
P2093
Fred E Bertrand
James A McCubrey
Linda S Steelman
P2860
P304
P356
10.1517/14728222.8.6.537
P407
P577
2004-12-01T00:00:00Z