about
p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling.The role of opiorphins (endogenous neutral endopeptidase inhibitors) in urogenital smooth muscle biologyAmisulpride is a potent 5-HT7 antagonist: relevance for antidepressant actions in vivoEvidence for the involvement of dopamine transporters in behavioral stimulant effects of modafinilEvolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligandDrug Repurposing Is a New Opportunity for Developing Drugs against Neuropsychiatric DisordersEngineering GPCR signaling pathways with RASSLsGlucagon-like peptide-1 receptor ligand interactions: structural cross talk between ligands and the extracellular domainStructure and function of serotonin G protein-coupled receptors.Intracellular delivery of an antisense oligonucleotide via endocytosis of a G protein-coupled receptor.The presynaptic component of the serotonergic system is required for clozapine's efficacy.Analgesic effect of a mixed T-type channel inhibitor/CB2 receptor agonist.Characterization of novel cannabinoid based T-type calcium channel blockers with analgesic effects.Finding new tricks for old drugs: an efficient route for public-sector drug discovery.Screening the receptorome.Directed molecular evolution of DREADDs: a generic approach to creating next-generation RASSLs.Serotonin receptors and heart valve disease--it was meant 2B.Functional characterization and analgesic effects of mixed cannabinoid receptor/T-type channel ligands.The first structure-activity relationship studies for designer receptors exclusively activated by designer drugs.Contributions of molecular biology to antipsychotic drug discovery: promises fulfilled or unfulfilled?Integrated Approaches for Genome-wide Interrogation of the Druggable Non-olfactory G Protein-coupled Receptor Superfamily.Regulation of G protein-coupled receptor export trafficking.Development and validation of a high-throughput calcium mobilization assay for the orphan receptor GPR88.Screening the receptorome reveals molecular targets responsible for drug-induced side effects: focus on 'fen-phen'.Receptors, endocytosis, and trafficking: the biological basis of targeted delivery of antisense and siRNA oligonucleotidesRegulation of the trafficking and function of G protein-coupled receptors by Rab1 GTPase in cardiomyocytes.Opportunities and challenges of psychiatric drug discovery: roles for scientists in academic, industry, and government settings.Mechanisms and strategies for effective delivery of antisense and siRNA oligonucleotides.Resolving Behavioral Output via Chemogenetic Designer Receptors Exclusively Activated by Designer DrugsEffect of Substitution on the Aniline Moiety of the GPR88 Agonist 2-PCCA: Synthesis, Structure-Activity Relationships, and Molecular Modeling Studies.Engineered G-protein Coupled Receptors are Powerful Tools to Investigate Biological Processes and Behaviors.Mastering tricyclic ring systems for desirable functional cannabinoid activity.Cellular uptake and intracellular trafficking of oligonucleotides: implications for oligonucleotide pharmacology.Cellular delivery of siRNA and antisense oligonucleotides via receptor-mediated endocytosis.The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor contains an immunoreceptor tyrosine-based inhibitory motif that activates Shp2.Targeted intracellular delivery of antisense oligonucleotides via conjugation with small-molecule ligands.Design, synthesis and pharmacological evaluation of 4-hydroxyphenylglycine and 4-hydroxyphenylglycinol derivatives as GPR88 agonists.Systemic neurotransmitter responses to clinically approved and experimental neuropsychiatric drugs
P2860
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P2860
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Mining the receptorome.
@ast
Mining the receptorome.
@en
type
label
Mining the receptorome.
@ast
Mining the receptorome.
@en
prefLabel
Mining the receptorome.
@ast
Mining the receptorome.
@en
P2860
P356
P1476
Mining the receptorome.
@en
P2093
Blaine N Armbruster
Bryan L Roth
P2860
P304
P356
10.1074/JBC.R400030200
P407
P577
2004-12-08T00:00:00Z