Identification of mutagenic metabolites of benzo(a)pyrene in mammalian cells.
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Involvement of alpha-PAK-interacting exchange factor in the PAK1-c-Jun NH(2)-terminal kinase 1 activation and apoptosis induced by benzo[a]pyreneDetection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals: discussionMetabolism of benzo[a]pyrene by human mammary epithelial cells: toxicity and DNA adduct formationEpoxides--is there a human health problem?Production of oxidative DNA damage during the metabolic activation of benzo[a]pyrene in human mammary epithelial cells correlates with cell killingModification of DNA by the benzo[a]pyrene metabolite diol-epoxide r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene.Differences in mutagenicity and cytotoxicity of (+)- and (-)-benzo[a]pyrene 4,5-oxide: a synergistic interaction of enantiomers.Impact of cellular metabolism on the biological effects of benzo[a]pyrene and related hydrocarbons.Conversion of normal to malignant phenotype: telomere shortening, telomerase activation, and genomic instability during immortalization of human oral keratinocytes.Phenotyping cytochromes P450 with monoclonal antibodies.Synergistic mechanisms in carcinogenesis by polycyclic aromatic hydrocarbons and by tobacco smoke: a bio-historical perspective with updates.Excision repair of benzo[a]pyrene-deoxyguanosine adducts in baby hamster kidney 21/C13 cells and in secondary mouse embryo fibroblasts C57BL/6JEnzymatic conversion of benzo(a)pyrene leading predominantly to the diol-epoxide r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene through a single enantiomer of r-7, t-8-dihydroxy-7,8-dihydrobenzo(a)pyrene(+/-)-7alpha,8beta-dihydroxy-9beta,10beta-epoxy-7,8,9,10-tetrahydrobenzo(a)-pyrene is an intermediate in the metabolism and binding to DNA of benzo(a)pyreneA bacteriophage system for screening and study of biologically active polycyclic aromatic hydrocarbons and related compounds.Metabolism of benzo[a]pyrene: conversion of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene to highly mutagenic 7,8-diol-9,10-epoxides.(+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo (a)pyrene: a potent skin carcinogen when applied topically to miceMutagenicity and cytotoxicity of benz[alpha]anthracene diol epoxides and tetrahydro-epoxides: exceptional activity of the bay region 1,2-epoxidesFormation and persistence of benzo(a)pyrene metabolite-DNA adducts.Tumorigenicity of five dihydrodiols of benz(a)anthracene on mouse skin: exceptional activity of benz(a)anthracene 3,4-dihydrodiol.Mechanism of phage phiX174 DNA inactivation by benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide.Assignment of a locus required for flavoprotein-linked monooxygenase expression to human chromosome 2.Chloride ions catalyze the formation of cis adducts in the binding of anti-benzo[a]pyrene diol epoxide to nucleic acids.Aryl hydrocarbon hydroxylase in cultured lymphocytes of twinsSpecificity of chemiluminescence in the metabolism of benzo[a]pyrene to its carcinogenic diol epoxide.Effect of histone acetylation on the formation and removal of B(a)P chromatin adducts.Tumour-initiating activities on mouse skin of dihydrodiols derived from benzo[a]pyrene.Hydrolysis of benzo[a]pyrene diol epoxide and its covalent binding to DNA proceed through similar rate-determining steps.Phenotyping of cytochromes P-450 in human tissues with monoclonal antibodiesEpoxidation reactions catalyzed by rat liver cytochromes P-450 and P-448 occur at different faces of the 8,9-double bond of 8-methylbenz[a]anthracene.Base insertion and deletion mutations induced in an Escherichia coli plasmid by benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxideShorter telomere length in peripheral blood lymphocytes of workers exposed to polycyclic aromatic hydrocarbonsConstitutive uncoupling of pathways of gene expression that control growth and differentiation in myeloid leukemia: a model for the origin and progression of malignancySpecificity in interaction of benzo[a]pyrene with nuclear macromolecules: implication of derivatives of two dihydrodiols in protein bindingCigarette side-stream smoke lung and bladder carcinogenesis: inducing mutagenic acrolein-DNA adducts, inhibiting DNA repair and enhancing anchorage-independent-growth cell transformation.Effect of benzo[a]pyrene-diolepoxide on infectivity and in vitro translation of phage MS2 RNAIdentification of 7,12-dimethylbenz[a]anthracene metabolites that lead to mutagenesis in mammalian cells.Chemical carcinogens produce mutations to ouabain resistance in transformable C3H/10T1/2 Cl 8 mouse fibroblastsHuman bronchus-mediated mutagenesis of mammalian cells by carcinogenic polynuclear aromatic hydrocarbonsLiver cell-mediated mutagenesis of mammalian cells by liver carcinogens.
P2860
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P2860
Identification of mutagenic metabolites of benzo(a)pyrene in mammalian cells.
description
1976 nî lūn-bûn
@nan
1976年の論文
@ja
1976年論文
@yue
1976年論文
@zh-hant
1976年論文
@zh-hk
1976年論文
@zh-mo
1976年論文
@zh-tw
1976年论文
@wuu
1976年论文
@zh
1976年论文
@zh-cn
name
Identification of mutagenic metabolites of benzo(a)pyrene in mammalian cells.
@ast
Identification of mutagenic metabolites of benzo(a)pyrene in mammalian cells.
@en
type
label
Identification of mutagenic metabolites of benzo(a)pyrene in mammalian cells.
@ast
Identification of mutagenic metabolites of benzo(a)pyrene in mammalian cells.
@en
prefLabel
Identification of mutagenic metabolites of benzo(a)pyrene in mammalian cells.
@ast
Identification of mutagenic metabolites of benzo(a)pyrene in mammalian cells.
@en
P2093
P2860
P356
P1476
Identification of mutagenic metabolites of benzo(a)pyrene in mammalian cells.
@en
P2093
P2860
P304
P356
10.1073/PNAS.73.2.607
P407
P577
1976-02-01T00:00:00Z