Antifolate-resistant mutants of Plasmodium falciparum dihydrofolate reductase.
about
Evidence of Plasmodium falciparum malaria resistant to atovaquone and proguanil hydrochloride: case reportsStructure-activity relationships of Bacillus cereus and Bacillus anthracis dihydrofolate reductase: toward the identification of new potent drug leadsHomology building as a means to define antigenic epitopes on dihydrofolate reductase (DHFR) from Plasmodium falciparumPredicting resistance mutations using protein design algorithmsMalarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised targetCombined Spatial Limitation around Residues 16 and 108 of Plasmodium falciparum Dihydrofolate Reductase Explains Resistance to CycloguanilEfficacy of sulphadoxine-pyrimethamine for intermittent preventive treatment of malaria in pregnancy, Mansa, ZambiaAdaptive copy number evolution in malaria parasitesFitness trade-offs in the evolution of dihydrofolate reductase and drug resistance in Plasmodium falciparumMolecular analysis of chloroquine and sulfadoxine-pyrimethamine resistance-associated alleles in Plasmodium falciparum isolates from NicaraguaTransformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanilBiochemical and functional characterization of Plasmodium falciparum GTP cyclohydrolase IOrigin of robustness in generating drug-resistant malaria parasitesConflicting requirements of Plasmodium falciparum dihydrofolate reductase mutations conferring resistance to pyrimethamine-WR99210 combination.WISDOM-II: screening against multiple targets implicated in malaria using computational grid infrastructures.Longitudinal survey of Plasmodium falciparum infection in Vietnam: characteristics of antimalarial resistance and their associated factorsMolecular basis of in vivo resistance to sulfadoxine-pyrimethamine in African adult patients infected with Plasmodium falciparum malaria parasites.Selection of drug resistant mutants from random library of Plasmodium falciparum dihydrofolate reductase in Plasmodium berghei modelThe dynamics of mutations associated with anti-malarial drug resistance in Plasmodium falciparum2,4-diaminopteridine-based compounds as precursors for de novo synthesis of antifolates: a novel class of antimalarials.Crystal structure of dihydrofolate reductase from Plasmodium vivax: pyrimethamine displacement linked with mutation-induced resistance.In vitro generation of novel pyrimethamine resistance mutations in the Toxoplasma gondii dihydrofolate reductaseEmergence of resistance to atovaquone-proguanil in malaria parasites: insights from computational modeling and clinical case reportsIdentification of pyrimethamine- and chloroquine-resistant Plasmodium falciparum in Africa between 1984 and 1998: genotyping of archive blood samplesAnti-folate drug resistance in Africa: meta-analysis of reported dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) mutant genotype frequencies in African Plasmodium falciparum parasite populations.Antifolate agents: a patent review (2006 - 2010).Pyrimethamine and WR99210 exert opposing selection on dihydrofolate reductase from Plasmodium vivax.A high-coverage artificial chromosome library for the genome-wide screening of drug-resistance genes in malaria parasitesCompensatory mutations restore fitness during the evolution of dihydrofolate reductaseBinding modes of 2,4-diaminoquinazoline and 2,4-diaminopteridine analogs to P. falciparum dihydrofolate reductase enzyme: Molecular docking studies.Quadruple mutations in dihydrofolate reductase of Plasmodium falciparum isolates from Car Nicobar Island, India.Whole genome re-sequencing identifies a mutation in an ABC transporter (mdr2) in a Plasmodium chabaudi clone with altered susceptibility to antifolate drugs.Evaluation of prevalence's of pfdhfr and pfdhps mutations in Angola.Molecular determination of point mutation haplotypes in the dihydrofolate reductase and dihydropteroate synthase of Plasmodium falciparum in three districts of northern TanzaniaThe mechanisms of resistance to antimalarial drugs in Plasmodium falciparum.Drug resistance to sulphadoxine-pyrimethamine in Plasmodium falciparum malaria in Mlimba, TanzaniaTransgenic Plasmodium parasites stably expressing Plasmodium vivax dihydrofolate reductase-thymidylate synthase as in vitro and in vivo models for antifolate screening.Independent evolution of pyrimethamine resistance in Plasmodium falciparum isolates in Melanesia.Adaptive evolution and fixation of drug-resistant Plasmodium falciparum genotypes in pregnancy-associated malaria: 9-year results from the QuEERPAM studyThe F423Y mutation in the pfmdr2 gene and mutations N51I, C59R, and S108N in the pfdhfr gene are independently associated with pyrimethamine resistance in Plasmodium falciparum isolates.
P2860
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P2860
Antifolate-resistant mutants of Plasmodium falciparum dihydrofolate reductase.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Antifolate-resistant mutants of Plasmodium falciparum dihydrofolate reductase.
@ast
Antifolate-resistant mutants of Plasmodium falciparum dihydrofolate reductase.
@en
type
label
Antifolate-resistant mutants of Plasmodium falciparum dihydrofolate reductase.
@ast
Antifolate-resistant mutants of Plasmodium falciparum dihydrofolate reductase.
@en
prefLabel
Antifolate-resistant mutants of Plasmodium falciparum dihydrofolate reductase.
@ast
Antifolate-resistant mutants of Plasmodium falciparum dihydrofolate reductase.
@en
P2093
P2860
P356
P1476
Antifolate-resistant mutants of Plasmodium falciparum dihydrofolate reductase.
@en
P2093
R Sirawaraporn
T Sathitkul
W Sirawaraporn
P2860
P304
P356
10.1073/PNAS.94.4.1124
P407
P50
P577
1997-02-01T00:00:00Z