Energy coupling in DNA gyrase and the mechanism of action of novobiocin. - Wikidata - awgldk - TriplyDB

Energy coupling in DNA gyrase and the mechanism of action of novobiocin.

Energy coupling in DNA gyrase and the mechanism of action of novobiocin.

http://www.wikidata.org/entity/Q35994466

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Crystal structures of Escherichia coli topoisomerase IV ParE subunit (24 and 43 kilodaltons): a single residue dictates differences in novobiocin potency against topoisomerase IV and DNA gyrase Biochemistry of homologous recombination in Escherichia coli DNA gyrase, topoisomerase IV, and the 4-quinolones Targeting DNA topoisomerase II in cancer chemotherapy A model for the mechanism of strand passage by DNA gyrase A monoclonal antibody that inhibits mycobacterial DNA gyrase by a novel mechanism.Dimerization of Escherichia coli DNA-gyrase B provides a structural mechanism for activating the ATPase catalytic center An open conformation of the Thermus thermophilus gyrase B ATP-binding domain Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187 Structural basis for gate-DNA recognition and bending by type IIA topoisomerases Differential ATP binding and intrinsic ATP hydrolysis by amino-terminal domains of the yeast Mlh1 and Pms1 proteins.A novel high-throughput cell-based assay aimed at identifying inhibitors of DNA metabolism in bacteria A classification based framework for quantitative description of large-scale microarray data.The ancestral role of ATP hydrolysis in type II topoisomerases: prevention of DNA double-strand breaks.Components of SurA required for outer membrane biogenesis in uropathogenic Escherichia coli.Discovery, characterization and comparison of inhibitors of Bacillus anthracis and Staphylococcus aureus replicative DNA helicases.Modulation of gyrase-mediated DNA cleavage and cell killing by ATP.Cloning and characterization of a DNA gyrase A gene from Escherichia coli that confers clinical resistance to 4-quinolones.Gyrase inhibitors and thymine starvation disrupt the normal pattern of plasmid RK2 localization in Escherichia coli A high-throughput fluorescence polarization assay for inhibitors of gyrase B Novobiocin inhibits passive chromatin assembly in vitro.A topoisomerase from Escherichia coli related to DNA gyrase DNA gyrase: purification and catalytic properties of a fragment of gyrase B protein Homologous pairing in genetic recombination: complexes of recA protein and DNA.The interaction of drugs with DNA gyrase: a model for the molecular basis of quinolone action.Complementation of a Treponema denticola flgE mutant with a novel coumermycin A1-resistant T. denticola shuttle vector system.Bacillus subtilis deoxyribonucleic acid gyrase Structure-based design and screening of inhibitors for an essential bacterial GTPase, Der.Exploiting bacterial DNA gyrase as a drug target: current state and perspectives.The RAD3 gene of Saccharomyces cerevisiae encodes a DNA-dependent ATPase DNA-strand exchange promoted by RecA protein in the absence of ATP: implications for the mechanism of energy transduction in protein-promoted nucleic acid transactions.DNA gyrase: structure and function.In memoriam: PNAS Editor-in-Chief Nicholas R. Cozzarelli (1938-2006)DNA topoisomerase II as a target for cancer chemotherapy.Alteration of Escherichia coli topoisomerase IV to novobiocin resistance.Roles of novobiocin-sensitive topoisomerases in chloroplast DNA replication in Chlamydomonas reinhardtii Progress in the discovery of treatments for C. difficile infection: A clinical and medicinal chemistry review.The effect of Escherichia coli Uvr protein binding on the topology of supercoiled DNA.Quinolone resistance mutations in topoisomerase IV: relationship to the flqA locus and genetic evidence that topoisomerase IV is the primary target and DNA gyrase is the secondary target of fluoroquinolones in Staphylococcus aureus.Discovery of ATP-Competitive Inhibitors of tRNAIle Lysidine Synthetase (TilS) by High-Throughput Screening.

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P2860

Energy coupling in DNA gyrase and the mechanism of action of novobiocin.

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Energy coupling in DNA gyrase and the mechanism of action of novobiocin.

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Energy coupling in DNA gyrase and the mechanism of action of novobiocin.

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Energy coupling in DNA gyrase and the mechanism of action of novobiocin.

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Energy coupling in DNA gyrase and the mechanism of action of novobiocin.

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Energy coupling in DNA gyrase and the mechanism of action of novobiocin.

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Energy coupling in DNA gyrase and the mechanism of action of novobiocin.

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Brown PO

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Cozzarelli NR

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P2860

The determination of enzyme inhibitor constants

A proposed common allosteric mechanism for active transport, muscle contraction, and ribosomal translocation.

DNA gyrase: an enzyme that introduces superhelical turns into DNA.

Adenylyl imidodiphosphate, an adenosine triphosphate analog containing a P--N--P linkage.

Role of DNA gyrase in phiX replicative-form replication in vitro.

Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyrase.

Strand breakage by the DNA untwisting enzyme results in covalent attachment of the enzyme to DNA

Mechanism of action of nalidixic acid: purification of Escherichia coli nalA gene product and its relationship to DNA gyrase and a novel nicking-closing enzyme.

Nalidixic acid resistance: a second genetic character involved in DNA gyrase activity.

The mechanism of action of inhibitors of DNA synthesis.

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