Manipulating the bioenergetics of alloreactive T cells causes their selective apoptosis and arrests graft-versus-host disease.
about
Posttranscriptional control of T cell effector function by aerobic glycolysisTherapeutics for Graft-versus-Host Disease: From Conventional Therapies to Novel Virotherapeutic StrategiesTargeting Homeostatic T Cell Proliferation to Control Beta-Cell AutoimmunityT cell metabolism drives immunityMetabolic reprogramming and metabolic dependency in T cellsMitochondria in the regulation of innate and adaptive immunityTreatment of dyslipidemia in allogeneic hematopoietic stem cell transplant patientsImmunometabolism of regulatory T cellsThe role of Fatty Acid oxidation in the metabolic reprograming of activated t-cellsAllogeneic transplantation, Fas signaling, and dysregulation of hepcidinDynamic Metabolism in Immune ResponseTumour suppressor Fus1 provides a molecular link between inflammatory response and mitochondrial homeostasisThe glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector functionIL-15 Harnesses Pro-inflammatory Function of TEMRA CD8 in Kidney-Transplant Recipients.Metabolic reprogramming towards aerobic glycolysis correlates with greater proliferative ability and resistance to metabolic inhibition in CD8 versus CD4 T cells.Anaplerotic metabolism of alloreactive T cells provides a metabolic approach to treat graft-versus-host disease.α-1-Antitrypsin (AAT)-modified donor cells suppress GVHD but enhance the GVL effect: a role for mitochondrial bioenergetics.An exploratory analysis of mitochondrial haplotypes and allogeneic hematopoietic cell transplantation outcomes.Thiol/redox metabolomic profiling implicates GSH dysregulation in early experimental graft versus host disease (GVHD).Inhibition of fatty acid metabolism ameliorates disease activity in an animal model of multiple sclerosisMetabolic pathways in T cell fate and function.Programmed death-1 controls T cell survival by regulating oxidative metabolism.Early changes in the metabolic profile of activated CD8(+) T cells.Targeting T Cell Bioenergetics by Modulating P-Glycoprotein Selectively Depletes Alloreactive T Cells To Prevent Graft-versus-Host Disease.Distinct metabolic programs in activated T cells: opportunities for selective immunomodulation.Glucose Oxidation Is Critical for CD4+ T Cell Activation in a Mouse Model of Systemic Lupus Erythematosus.IL-1 Receptor Blockade Alleviates Graft-versus-Host Disease through Downregulation of an Interleukin-1β-Dependent Glycolytic Pathway in Th17 CellsMatched and mismatched metabolic fuels in lymphocyte function.Metabolic regulation of T lymphocytes.Metabolic switching and fuel choice during T-cell differentiation and memory development.Changing the energy of an immune responseProgrammed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality.Host programmed death ligand 1 is dominant over programmed death ligand 2 expression in regulating graft-versus-host disease lethality.Effector T cells require fatty acid metabolism during murine graft-versus-host disease.Metabolic Factors that Contribute to Lupus PathogenesisNormalization of CD4+ T cell metabolism reverses lupusEnergy metabolism and rheumatic diseases: from cell to organismmTOR, metabolism, and the regulation of T-cell differentiation and function.Biology of graft-versus-host responses: recent insightsMitochondria as oxidative signaling organelles in T-cell activation: physiological role and pathological implications.
P2860
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P2860
Manipulating the bioenergetics of alloreactive T cells causes their selective apoptosis and arrests graft-versus-host disease.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Manipulating the bioenergetics ...... sts graft-versus-host disease.
@ast
Manipulating the bioenergetics ...... sts graft-versus-host disease.
@en
type
label
Manipulating the bioenergetics ...... sts graft-versus-host disease.
@ast
Manipulating the bioenergetics ...... sts graft-versus-host disease.
@en
prefLabel
Manipulating the bioenergetics ...... sts graft-versus-host disease.
@ast
Manipulating the bioenergetics ...... sts graft-versus-host disease.
@en
P2093
P2860
P1476
Manipulating the bioenergetics ...... sts graft-versus-host disease.
@en
P2093
Anthony W Opipari
Daniel R Wahl
Erin Gatza
Gary D Glick
James L M Ferrara
Pavan Reddy
Thomas B Sundberg
P2860
P356
10.1126/SCITRANSLMED.3001975
P407
P577
2011-01-01T00:00:00Z