Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells.
about
Dynamic rerouting of the carbohydrate flux is key to counteracting oxidative stressNitric oxide and peroxynitrite in health and diseaseRole of nitrosative stress and peroxynitrite in the pathogenesis of diabetic complications. Emerging new therapeutical strategiesUnderstanding the Causes and Implications of Endothelial Metabolic Variation in Cardiovascular Disease through Genome-Scale Metabolic ModelingProtein Modifications as Manifestations of Hyperglycemic Glucotoxicity in Diabetes and Its ComplicationsThe Role of the Reactive Oxygen Species and Oxidative Stress in the Pathomechanism of the Age-Related Ocular Diseases and Other Pathologies of the Anterior and Posterior Eye Segments in AdultsHyperglycemic Stress and Carbon Stress in Diabetic GlucotoxicityRoles of Pyruvate, NADH, and Mitochondrial Complex I in Redox Balance and Imbalance in β Cell Function and DysfunctionMetabolic Enzymes Enjoying New Partnerships as RNA-Binding ProteinsPrinciples of targeting endothelial cell metabolism to treat angiogenesis and endothelial cell dysfunction in diseaseReactive oxygen species adversely impacts bone marrow microenvironment in diabetesDiabetes and Alzheimer disease, two overlapping pathologies with the same background: oxidative stressSubcellular dynamics of multifunctional protein regulation: mechanisms of GAPDH intracellular translocationSources and implications of NADH/NAD(+) redox imbalance in diabetes and its complicationsPathophysiological Role of Peroxynitrite Induced DNA Damage in Human Diseases: A Special Focus on Poly(ADP-ribose) Polymerase (PARP)The diverse functions of GAPDH: views from different subcellular compartmentsOxidative Stress-Related Mechanisms and Antioxidant Therapy in Diabetic RetinopathyOxidative stress and diabetic complicationsAn integrated perspective on diabetic, alcoholic, and drug-induced neuropathy, etiology, and treatment in the US.Endothelial mitochondria--less respiration, more integration.Rab2A is a pivotal switch protein that promotes either secretion or ER-associated degradation of (pro)insulin in insulin-secreting cells.Islet endothelial activation and oxidative stress gene expression is reduced by IL-1Ra treatment in the type 2 diabetic GK ratDiabetes mellitus induces bone marrow microangiopathy.Diabetic neuropathy: mechanisms to managementMitochondria, endothelial cell function, and vascular diseases.Neuroinflammation and oxidative stress in diabetic neuropathy: futuristic strategies based on these targets.Metabolic Remodeling in Diabetic Cardiomyopathy.Hyperglycemia impairs proteasome function by methylglyoxalDiabetic cardiomyopathy: where we are and where we are going.Oxygen delivery, consumption, and conversion to reactive oxygen species in experimental models of diabetic retinopathyGlucose supply and insulin demand dynamics of antidiabetic agents.Vitamin B1 analog benfotiamine prevents diabetes-induced diastolic dysfunction and heart failure through Akt/Pim-1-mediated survival pathwayPathogenesis of chronic hyperglycemia: from reductive stress to oxidative stress.Therapeutic interventions and oxidative stress in diabetesRisk Factors Associated with Left Ventricular Diastolic Dysfunction in Type 2 Diabetic Patients without Hypertension.Postischemic poly (ADP-ribose) polymerase (PARP) inhibition reduces ischemia reperfusion injury in a hind-limb ischemia model.Oxidative stress and metabolic pathologies: from an adipocentric point of view.Oxidative stress: implications for the development of diabetic retinopathy and antioxidant therapeutic perspectives.Improvement of retinal vascular injury in diabetic rats by statins is associated with the inhibition of mitochondrial reactive oxygen species pathway mediated by peroxisome proliferator-activated receptor gamma coactivator 1alphaO-GlcNAc Modification: Friend or Foe in Diabetic Cardiovascular Disease.
P2860
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P2860
Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Inhibition of GAPDH activity b ...... c damage in endothelial cells.
@ast
Inhibition of GAPDH activity b ...... c damage in endothelial cells.
@en
type
label
Inhibition of GAPDH activity b ...... c damage in endothelial cells.
@ast
Inhibition of GAPDH activity b ...... c damage in endothelial cells.
@en
prefLabel
Inhibition of GAPDH activity b ...... c damage in endothelial cells.
@ast
Inhibition of GAPDH activity b ...... c damage in endothelial cells.
@en
P2093
P2860
P356
P1476
Inhibition of GAPDH activity b ...... c damage in endothelial cells.
@en
P2093
Csaba Szabó
Diane Edelstein
Luciano Rossetti
Michael Brownlee
Takeshi Matsumura
Xueliang Du
P2860
P304
P356
10.1172/JCI200318127
P407
P577
2003-10-01T00:00:00Z