The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology.
about
Structural basis for the binding of the membrane-proximal C-terminal region of chemokine receptor CCR2 with the cytosolic regulator FROUNT60 YEARS OF POMC: Regulation of feeding and energy homeostasis by α-MSHPharmacoperones: a new therapeutic approach for diseases caused by misfolded G protein-coupled receptorsSex differences in the physiology of eatingBiphasic effect of melanocortin agonists on metabolic rate and body temperatureRegion-specific differences in brain melanocortin receptors in rats of the lean phenotypeSevere Atherosclerosis and Hypercholesterolemia in Mice Lacking Both the Melanocortin Type 4 Receptor and Low Density Lipoprotein ReceptorA novel melanocortin-4 receptor mutation MC4R-P272L associated with severe obesity has increased propensity to be ubiquitinated in the ER in the face of correct foldingMelanocortin receptors in rat liver cells: change of gene expression and intracellular localization during acute-phase responseMelanocortin receptor 4 deficiency affects body weight regulation, grooming behavior, and substrate preference in the ratHow genetic errors in GPCRs affect their function: Possible therapeutic strategiesHunger and Satiety Gauge Reward SensitivityMelanocortin neurons: Multiple routes to regulation of metabolism.Regulation of appetite to treat obesity.New advances in models and strategies for developing anti-obesity drugs.AgRP and POMC neurons are hypophysiotropic and coordinately regulate multiple endocrine axes in a larval teleostBrain-derived neurotrophic factor in human subjects with function-altering melanocortin-4 receptor variants.The brain melanocortin system, sympathetic control, and obesity hypertension.Obesity pharmacotherapy: what is next?Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity.Functional variants of the melanocortin-4 receptor associated with the Odontoceti and Mysticeti suborders of cetaceansChaperoning G protein-coupled receptors: from cell biology to therapeuticsA small molecule agonist THIQ as a novel pharmacoperone for intracellularly retained melanocortin-4 receptor mutants.Ipsen 5i is a Novel Potent Pharmacoperone for Intracellularly Retained Melanocortin-4 Receptor Mutants.Loss of melanocortin-4 receptor function attenuates HPA responses to psychological stressNeonatal melanocortin receptor agonist treatment reduces play fighting and promotes adult attachment in prairie voles in a sex-dependent mannerMahoganoid and mahogany mutations rectify the obesity of the yellow mouse by effects on endosomal traffic of MC4R proteinDefect in MAPK signaling as a cause for monogenic obesity caused by inactivating mutations in the melanocortin-4 receptor gene.Neuropeptides in the pathophysiology and treatment of cachexia.A novel MC4R mutation associated with childhood-onset obesity: A case report.Insights into food preference in hybrid F1 of Siniperca chuatsi (♀) × Siniperca scherzeri (♂) mandarin fish through transcriptome analysis.Nicotine decreases food intake through activation of POMC neurons.Variation in the MC4R gene is associated with bone phenotypes in elderly Swedish women.Motor cortex-periaqueductal gray-spinal cord neuronal circuitry may involve in modulation of nociception: a virally mediated transsynaptic tracing study in spinally transected transgenic mouse model.Long-term weight-loss in gastric bypass patients carrying melanocortin 4 receptor variants.Developmental competence of antral follicles and their oocytes after gonadotrophin treatment of sows with gene polymorphisms for leptin and melanocortin receptors (Iberian pig)Pharmacological characterization of canine melancortin-4 receptor and its natural variant V213F.Functional studies on twenty novel naturally occurring melanocortin-4 receptor mutations.Obesity-induced hypertension: interaction of neurohumoral and renal mechanismsBiased signaling in naturally occurring mutations in human melanocortin-3 receptor gene.
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P2860
The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
@zh
2010年學術文章
@zh-hant
name
The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology.
@ast
The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology.
@en
type
label
The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology.
@ast
The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology.
@en
prefLabel
The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology.
@ast
The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology.
@en
P2860
P356
P1433
P1476
The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology
@en
P2093
Ya-Xiong Tao
P2860
P304
P356
10.1210/ER.2009-0037
P50
P577
2010-02-26T00:00:00Z