Disease-associated mutation in SRSF2 misregulates splicing by altering RNA-binding affinities.
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The new (dis)order in RNA regulationSpliceosomal gene mutations in myelodysplasia: molecular links to clonal abnormalities of hematopoiesisEmerging concepts of epigenetic dysregulation in hematological malignanciesDefective control of pre-messenger RNA splicing in human diseaseHow do messenger RNA splicing alterations drive myelodysplasia?Myelodysplasia-associated mutations in serine/arginine-rich splicing factor SRSF2 lead to alternative splicing of CDC25CThe pathogenicity of splicing defects: mechanistic insights into pre-mRNA processing inform novel therapeutic approaches.Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins.Myeloid neoplasms with isolated isochromosome 17q demonstrate a high frequency of mutations in SETBP1, SRSF2, ASXL1 and NRAS.Liver-Specific Deletion of SRSF2 Caused Acute Liver Failure and Early Death in Mice.RNA splicing factors as oncoproteins and tumour suppressors.Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome.RNA mis-splicing in disease.The determinants of alternative RNA splicing in human cells.A Systematic Evaluation of Methods for Tailoring Genome-Scale Metabolic Models.Transcriptomic Characterization of SF3B1 Mutation Reveals Its Pleiotropic Effects in Chronic Lymphocytic Leukemia.CRISPR-Cas9 technology and its application in haematological disorders.Therapeutic targeting of splicing in cancer.Splicing factor gene mutations in hematologic malignancies.Splicing Factor Mutations in Myelodysplasias: Insights from Spliceosome Structures.The C9ORF72 GGGGCC expansion forms RNA G-quadruplex inclusions and sequesters hnRNP H to disrupt splicing in ALS brains.Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma.Distinct splicing signatures affect converged pathways in myelodysplastic syndrome patients carrying mutations in different splicing regulators.A large-scale analysis of alternative splicing reveals a key role of QKI in lung cancer.Physiological Srsf2 P95H expression causes impaired hematopoietic stem cell functions and aberrant RNA splicing in mice.Exploiting differential RNA splicing patterns: a potential new group of therapeutic targets in cancer.Therapeutic Applications of Targeted Alternative Splicing to Cancer Treatment.Insights from structures of cancer-relevant pre-mRNA splicing factors.The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations.Splicing Factor Mutations in Cancer.Dissecting the Contributions of Cooperating Gene Mutations to Cancer Phenotypes and Drug Responses with Patient-Derived iPSCs.Alternative-splicing defects in cancer: Splicing regulators and their downstream targets, guiding the way to novel cancer therapeutics.Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types.Cellular network perturbations by disease-associated variants.Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicineAberrant splicing and defective mRNA production induced by somatic spliceosome mutations in myelodysplasia
P2860
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P2860
Disease-associated mutation in SRSF2 misregulates splicing by altering RNA-binding affinities.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Disease-associated mutation in ...... tering RNA-binding affinities.
@ast
Disease-associated mutation in ...... tering RNA-binding affinities.
@en
type
label
Disease-associated mutation in ...... tering RNA-binding affinities.
@ast
Disease-associated mutation in ...... tering RNA-binding affinities.
@en
prefLabel
Disease-associated mutation in ...... tering RNA-binding affinities.
@ast
Disease-associated mutation in ...... tering RNA-binding affinities.
@en
P2093
P2860
P50
P356
P1476
Disease-associated mutation in ...... tering RNA-binding affinities.
@en
P2093
Alex Penson
Kathryn S Reggio
Siddhartha Mukherjee
Yen K Lieu
P2860
P304
P356
10.1073/PNAS.1514105112
P407
P577
2015-08-10T00:00:00Z