Pentosan polysulfate increases affinity between ADAMTS-5 and TIMP-3 through formation of an electrostatically driven trimolecular complex. - Wikidata - awgldk - TriplyDB

Pentosan polysulfate increases affinity between ADAMTS-5 and TIMP-3 through formation of an electrostatically driven trimolecular complex.

Pentosan polysulfate increases affinity between ADAMTS-5 and TIMP-3 through formation of an electrostatically driven trimolecular complex.

http://www.wikidata.org/entity/Q36014585

about

Pentosan polysulfate: a novel therapy for the mucopolysaccharidoses Injectable and bioresponsive hydrogels for on-demand matrix metalloproteinase inhibition Sulfated glycosaminoglycans control the extracellular trafficking and the activity of the metalloprotease inhibitor TIMP-3.Antibody-based exosite inhibitors of ADAMTS-5 (aggrecanase-2)Systems Based Study of the Therapeutic Potential of Small Charged Molecules for the Inhibition of IL-1 Mediated Cartilage Degradation Cell-matrix interactions: focus on proteoglycan-proteinase interplay and pharmacological targeting in cancer.Engineered Tissue Inhibitor of Metalloproteinases-3 Variants Resistant to Endocytosis Have Prolonged Chondroprotective Activity.Low density lipoprotein receptor-related protein 1 (LRP1)-mediated endocytic clearance of a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4): functional differences of non-catalytic domains of ADAMTS-4 and ADAMTS-5 in LRP1 b Improved clinical outcome measures of knee pain and function with concurrent resolution of subchondral Bone Marrow Edema Lesion and joint effusion in an osteoarthritic patient following Pentosan Polysulphate Sodium treatment: a case report.Suramin Inhibits Osteoarthritic Cartilage Degradation by Increasing Extracellular Levels of Chondroprotective Tissue Inhibitor of Metalloproteinases 3.

P2860

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P2860

Pentosan polysulfate increases affinity between ADAMTS-5 and TIMP-3 through formation of an electrostatically driven trimolecular complex.

http://www.wikidata.org/entity/Q36014585

description

2012 nî lūn-bûn

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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2012年论文

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2012年论文

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name

Pentosan polysulfate increases ...... y driven trimolecular complex.

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Pentosan polysulfate increases ...... y driven trimolecular complex.

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type

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Pentosan polysulfate increases ...... y driven trimolecular complex.

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Pentosan polysulfate increases ...... y driven trimolecular complex.

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Pentosan polysulfate increases ...... y driven trimolecular complex.

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Pentosan polysulfate increases ...... y driven trimolecular complex.

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Biochemical Journal

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Pentosan polysulfate increases ...... y driven trimolecular complex.

@en

P2093

Barbara Mulloy

http://www.w3.org/2001/XMLSchema#string

Gillian Murphy

http://www.w3.org/2001/XMLSchema#string

Hideaki Nagase

http://www.w3.org/2001/XMLSchema#string

Linda Troeberg

http://www.w3.org/2001/XMLSchema#string

Meng-Huee Lee

http://www.w3.org/2001/XMLSchema#string

Peter Ghosh

http://www.w3.org/2001/XMLSchema#string

P2860

Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization

Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin

Antithrombin-S195A factor Xa-heparin structure reveals the allosteric mechanism of antithrombin activation

On the attribution and additivity of binding energies

Crystal structures of catrocollastatin/VAP2B reveal a dynamic, modular architecture of ADAM/adamalysin/reprolysin family proteins

Role of the antithrombin-binding pentasaccharide in heparin acceleration of antithrombin-proteinase reactions. Resolution of the antithrombin conformational change contribution to heparin rate enhancement

Glycosaminoglycan-binding properties and aggrecanase activities of truncated ADAMTSs: comparative analyses with ADAMTS-5, -9, -16 and -18

Increased backbone mobility in beta-barrel enhances entropy gain driving binding of N-TIMP-1 to MMP-3.

TIMP-3 binds to sulfated glycosaminoglycans of the extracellular matrix.

The C-terminal domains of ADAMTS-4 and ADAMTS-5 promote association with N-TIMP-3.

P304

307-315

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scholarly article

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10.1042/BJ20112159

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1

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443

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22299597

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3369482

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