Type I IFN induced by adenovirus serotypes 28 and 35 has multiple effects on T cell immunogenicity
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Methods and clinical development of adenovirus-vectored vaccines against mucosal pathogensAdHu5Ag85A Respiratory Mucosal Boost Immunization Enhances Protection against Pulmonary Tuberculosis in BCG-Primed Non-Human PrimatesType I IFN signaling in CD8- DCs impairs Th1-dependent malaria immunity.Aerosol vaccination with AERAS-402 elicits robust cellular immune responses in the lungs of rhesus macaques but fails to protect against high-dose Mycobacterium tuberculosis challenge.Hexon hypervariable region-modified adenovirus type 5 (Ad5) vectors display reduced hepatotoxicity but induce T lymphocyte phenotypes similar to Ad5 vectorsLate endosomal trafficking of alternative serotype adenovirus vaccine vectors augments antiviral innate immunity.Antigen expression determines adenoviral vaccine potency independent of IFN and STING signaling.Six host-range restricted poxviruses from three genera induce distinct gene expression profiles in an in vivo mouse modelSTAT2 Knockout Syrian Hamsters Support Enhanced Replication and Pathogenicity of Human Adenovirus, Revealing an Important Role of Type I Interferon Response in Viral ControlSafety and Immunogenicity of a rAd35-EnvA Prototype HIV-1 Vaccine in Combination with rAd5-EnvA in Healthy Adults (VRC 012)Vaccination with adenovirus serotypes 35, 26, and 48 elicits higher levels of innate cytokine responses than adenovirus serotype 5 in rhesus monkeysDifferential immunogenicity between HAdV-5 and chimpanzee adenovirus vector ChAdOx1 is independent of fiber and penton RGD loop sequences in miceComparative analysis of the magnitude, quality, phenotype, and protective capacity of simian immunodeficiency virus gag-specific CD8+ T cells following human-, simian-, and chimpanzee-derived recombinant adenoviral vector immunization.CXCL13 is a plasma biomarker of germinal center activity.Type I interferon-dependent activation of NK cells by rAd28 or rAd35, but not rAd5, leads to loss of vector-insert expressionRecent advances in antibody-inducing poxviral and adenoviral vectored vaccine delivery platforms for difficult disease targets.Cellular immunity induced by a recombinant adenovirus- human dendritic cell vaccine for melanoma.Blocking Virus Replication during Acute Murine Cytomegalovirus Infection Paradoxically Prolongs Antigen Presentation and Increases the CD8+ T Cell Response by Preventing Type I IFN-Dependent Depletion of Dendritic Cells.Enhanced antitumor immunotherapeutic effect of B-cell-based vaccine transduced with modified adenoviral vector containing type 35 fiber structures.Adenoviral vaccine induction of CD8+ T cell memory inflation: Impact of co-infection and infection order.Inhibition of type I interferon responses by adenovirus serotype-dependent Gas6 binding.Virus-Like-Vaccines against HIV.
P2860
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P2860
Type I IFN induced by adenovirus serotypes 28 and 35 has multiple effects on T cell immunogenicity
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2012 nî lūn-bûn
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2012年学术文章
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name
Type I IFN induced by adenovir ...... fects on T cell immunogenicity
@ast
Type I IFN induced by adenovir ...... fects on T cell immunogenicity
@en
type
label
Type I IFN induced by adenovir ...... fects on T cell immunogenicity
@ast
Type I IFN induced by adenovir ...... fects on T cell immunogenicity
@en
prefLabel
Type I IFN induced by adenovir ...... fects on T cell immunogenicity
@ast
Type I IFN induced by adenovir ...... fects on T cell immunogenicity
@en
P2093
P2860
P50
P356
P1476
Type I IFN induced by adenovir ...... fects on T cell immunogenicity
@en
P2093
Constantinos Petrovas
Elias Haddad
Emma Gostick
François Lefebvre
Jason G D Gall
Karin Loré
Mark J Cameron
Matthew J Johnson
Richard A Koup
Robert A Seder
P2860
P304
P356
10.4049/JIMMUNOL.1103717
P407
P577
2012-05-14T00:00:00Z