PTPN11-associated mutations in the heart: has LEOPARD changed Its RASpots? - Wikidata - awgldk - TriplyDB

PTPN11-associated mutations in the heart: has LEOPARD changed Its RASpots?

PTPN11-associated mutations in the heart: has LEOPARD changed Its RASpots?

http://www.wikidata.org/entity/Q36025665

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Structural insights into Noonan/LEOPARD syndrome-related mutants of protein-tyrosine phosphatase SHP2 (PTPN11)Polymorphisms of PTPN11 gene could influence serum lipid levels in a sex-specific pattern.Modeling heart disease in a dish: from somatic cells to disease-relevant cardiomyocytes.The protein tyrosine phosphatase Shp2 is required for the generation of oligodendrocyte progenitor cells and myelination in the mouse telencephalon.Sun-induced freckling: ephelides and solar lentigines.Genetic alterations of protein tyrosine phosphatases in human cancers.Recent advances in RASopathies.Do you know this syndrome? Leopard syndrome.Protein tyrosine phosphatases in cardiac physiology and pathophysiology.Gain-of-function mutations in the gene encoding the tyrosine phosphatase SHP2 induce hydrocephalus in a catalytically dependent manner.Rapidly progressive hypertrophic cardiomyopathy in an infant with Noonan syndrome with multiple lentigines: palliative treatment with a rapamycin analog.

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PTPN11-associated mutations in the heart: has LEOPARD changed Its RASpots?

http://www.wikidata.org/entity/Q36025665

description

2011 nî lūn-bûn

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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2011年论文

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name

PTPN11-associated mutations in the heart: has LEOPARD changed Its RASpots?

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PTPN11-associated mutations in the heart: has LEOPARD changed Its RASpots?

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PTPN11-associated mutations in the heart: has LEOPARD changed Its RASpots?

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PTPN11-associated mutations in the heart: has LEOPARD changed Its RASpots?

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PTPN11-associated mutations in the heart: has LEOPARD changed Its RASpots?

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PTPN11-associated mutations in the heart: has LEOPARD changed Its RASpots?

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J.TCM.2012.03.006

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Trends in Cardiovascular Medicine

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PTPN11-associated mutations in the heart: has LEOPARD changed Its RASpots?

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Jessica Lauriol

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Maria I Kontaridis

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P2860

Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

Germline missense mutations affecting KRAS Isoform B are associated with a severe Noonan syndrome phenotype

Grouping of multiple-lentigines/LEOPARD and Noonan syndromes on the PTPN11 gene

Functional effects of PTPN11 (SHP2) mutations causing LEOPARD syndrome on epidermal growth factor-induced phosphoinositide 3-kinase/AKT/glycogen synthase kinase 3beta signaling

Reduced phosphatase activity of SHP-2 in LEOPARD syndrome: consequences for PI3K binding on Gab1

Mutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonan-like syndrome with loose anagen hair

Multiple in vivo phosphorylated tyrosine phosphatase SHP-2 engages binding to Grb2 via tyrosine 584

Diversity and functional consequences of germline and somatic PTPN11 mutations in human disease.

Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras

A novel membrane glycoprotein, SHPS-1, that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion

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