Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway
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Undercover: gene control by metabolites and metabolic enzymesThe importance of serine metabolism in cancerAutophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells.Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolismMetabolic interactions in cancer: cellular metabolism at the interface between the microenvironment, the cancer cell phenotype and the epigenetic landscape.One-carbon metabolism in cancer.One-Carbon Metabolism in Health and Disease.Traditional and novel tools to probe the mitochondrial metabolism in health and disease.Serine one-carbon catabolism with formate overflow.Population FBA predicts metabolic phenotypes in yeast.Inflammation, mitochondrial metabolism and nutrition: the multi-faceted progression of non-alcoholic fatty liver disease to hepatocellular carcinomaTracing insights into human metabolism using chemical engineering approaches.An LC-MS chemical derivatization method for the measurement of five different one-carbon states of cellular tetrahydrofolate.Reverse engineering the cancer metabolic network using flux analysis to understand drivers of human disease.Human mitochondrial MTHFD2 is a dual redox cofactor-specific methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase.The role of mitochondrial folate enzyme MTHFD1L in esophageal squamous cell carcinoma.Targeting Metabolism for Cancer Therapy.Mitochondrial translation requires folate-dependent tRNA methylation.Mice deficient in the Shmt2 gene have mitochondrial respiration defects and are embryonic lethal.Dihydrofolate Reductase/Thymidylate Synthase Fine-Tunes the Folate Status and Controls Redox Homeostasis in Plants.A genetically encoded tool for manipulation of NADP+/NADPH in living cells.Metabolic Alterations in Cancer Cells and the Emerging Role of Oncometabolites as Drivers of Neoplastic Change.Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma.Mitochondrial nicotinamide adenine dinucleotide reduced (NADH) oxidation links the tricarboxylic acid (TCA) cycle with methionine metabolism and nuclear DNA methylation.Recent advances in cancer metabolism: a technological perspective.Deletion of the neural tube defect-associated gene Mthfd1l disrupts one-carbon and central energy metabolism in mouse embryos.Mitochondria and Cancer.Biochemistry: A toxin that fuels metabolismIncreased formate overflow is a hallmark of oxidative cancer.Protein interaction and functional data indicate MTHFD2 involvement in RNA processing and translationMetabolomics and Isotope TracingWeanling Offspring of Dams Maintained on Serine-Deficient Diet Are Vulnerable to Oxidative Stress
P2860
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P2860
Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway
description
2016 nî lūn-bûn
@nan
2016年の論文
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2016年学术文章
@wuu
2016年学术文章
@zh-cn
2016年学术文章
@zh-hans
2016年学术文章
@zh-my
2016年学术文章
@zh-sg
2016年學術文章
@yue
2016年學術文章
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2016年學術文章
@zh-hant
name
Reversal of Cytosolic One-Carb ...... e Mitochondrial Folate Pathway
@ast
Reversal of Cytosolic One-Carb ...... e Mitochondrial Folate Pathway
@en
type
label
Reversal of Cytosolic One-Carb ...... e Mitochondrial Folate Pathway
@ast
Reversal of Cytosolic One-Carb ...... e Mitochondrial Folate Pathway
@en
prefLabel
Reversal of Cytosolic One-Carb ...... e Mitochondrial Folate Pathway
@ast
Reversal of Cytosolic One-Carb ...... e Mitochondrial Folate Pathway
@en
P2093
P2860
P1433
P1476
Reversal of Cytosolic One-Carb ...... e Mitochondrial Folate Pathway
@en
P2093
Jonathan M Ghergurovich
Joshua D Rabinowitz
Mark Esposito
Raphael J Morscher
Yibin Kang
P2860
P304
P356
10.1016/J.CMET.2016.04.016
P577
2016-05-19T00:00:00Z