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NVP-LDE225, a potent and selective SMOOTHENED antagonist reduces melanoma growth in vitro and in vivoImmunohistochemical analysis of Sonic hedgehog signalling in normal human urinary tract developmentRAB23 mutations in Carpenter syndrome imply an unexpected role for hedgehog signaling in cranial-suture development and obesityStructural basis of SUFU-GLI interaction in human Hedgehog signalling regulation.The hedgehog receptor patched is involved in cholesterol transportThe Hedgehog gene family of the cnidarian, Nematostella vectensis, and implications for understanding metazoan Hedgehog pathway evolutionHedgehog Cholesterolysis: Specialized Gatekeeper to Oncogenic SignalingHedgehog signaling pathway in ovarian cancerOvergrowth of a mouse model of Simpson-Golabi-Behmel syndrome is partly mediated by Indian hedgehogCilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conservedMice with a targeted mutation of patched2 are viable but develop alopecia and epidermal hyperplasiaSet7 mediated Gli3 methylation plays a positive role in the activation of Sonic Hedgehog pathway in mammalsInactivation of Patched1 in the mouse limb has novel inhibitory effects on the chondrogenic program.Loss of function mutation in the palmitoyl-transferase HHAT leads to syndromic 46,XY disorder of sex development by impeding Hedgehog protein palmitoylation and signalingdelta-EF1 is a negative regulator of Ihh in the developing growth plate.Characterization of two ectrodactyly-associated translocation breakpoints separated by 2.5 Mb on chromosome 2q14.1-q14.2.Hedgehog-induced phosphorylation by CK1 sustains the activity of Ci/Gli activatorActivation of heterotrimeric G proteins by Smoothened.The role of sonic hedgehog-Gli2 pathway in the masculinization of external genitaliaRegulation of smoothened by Drosophila G-protein-coupled receptor kinases.Hedgehog/Notch-induced premature gliogenesis represents a new disease mechanism for Hirschsprung disease in mice and humansThe Eya1 phosphatase promotes Shh signaling during hindbrain development and oncogenesis.Hedgehog signaling in hematopoiesis.Regulation of Hedgehog signaling by ubiquitination.Regulation of human PTCH1b expression by different 5' untranslated region cis-regulatory elements.Maintenance of the BMP4-dependent stress erythropoiesis pathway in the murine spleen requires hedgehog signalingA network medicine approach to human disease.Dosage-dependent hedgehog signals integrated with Wnt/beta-catenin signaling regulate external genitalia formation as an appendicular program.Suppressor of fused impedes Ci/Gli nuclear import by opposing Trn/Kapβ2 in Hedgehog signaling.Proteins of the Hedgehog signaling pathway as therapeutic targets against cancer.Hedgehog signaling in skin cancersDecoding Ci: from partial degradation to inhibition.An in vitro gastrulation model recapitulates the morphogenetic impact of pharmacological inhibitors of developmental signaling pathways.The hedgehog regulated oncogenes Gli1 and Gli2 block myoblast differentiation by inhibiting MyoD-mediated transcriptional activation.An essential role for Gα(i2) in Smoothened-stimulated epithelial cell proliferation in the mammary gland.EvoTol: a protein-sequence based evolutionary intolerance framework for disease-gene prioritization.An old friend with new skills: Imiquimod as novel inhibitor of Hedgehog signaling in basal cell carcinoma.Oncogenic KRAS activates hedgehog signaling pathway in pancreatic cancer cells.Spatiotemporal patterns of the Huntingtin-interacting protein 1-related gene in the mouse head.Activated Hedgehog-GLI Signaling Causes Congenital Ureteropelvic Junction Obstruction.
P2860
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P2860
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Hedgehog signaling and congenital malformations.
@ast
Hedgehog signaling and congenital malformations.
@en
type
label
Hedgehog signaling and congenital malformations.
@ast
Hedgehog signaling and congenital malformations.
@en
prefLabel
Hedgehog signaling and congenital malformations.
@ast
Hedgehog signaling and congenital malformations.
@en
P2860
P1433
P1476
Hedgehog signaling and congenital malformations.
@en
P2093
E Nieuwenhuis
P2860
P304
P356
10.1111/J.1399-0004.2004.00360.X
P577
2005-03-01T00:00:00Z