Direct Identification of Hundreds of Expression-Modulating Variants using a Multiplexed Reporter Assay.
about
Genetic insights into juvenile idiopathic arthritis derived from deep whole genome sequencing.Effects of Type 1 Diabetes Risk Alleles on Immune Cell Gene ExpressionSystematic dissection of genomic features determining transcription factor binding and enhancer function.cepip: context-dependent epigenomic weighting for prioritization of regulatory variants and disease-associated genes.Optimizing the chances of success in the search for epigenetic biomarkers: Embracing genetic variation.Unified Sequence-Based Association Tests Allowing for Multiple Functional Annotations and Meta-Analysis of Noncoding Variation in Metabochip Data.A Genetic Variant Associated with Five Vascular Diseases Is a Distal Regulator of Endothelin-1 Gene Expression.Predicting gene expression in massively parallel reporter assays: A comparative study.The power of multiplexed functional analysis of genetic variants.CRISPR Screens to Discover Functional Noncoding Elements.Accurate eQTL prioritization with an ensemble-based framework.Understanding Human Autoimmunity and Autoinflammation Through Transcriptomics.Predicting enhancer activity and variant impact using gkm-SVM.High-Throughput Assays to Assess the Functional Impact of Genetic Variants: A Road Towards Genomic-Driven Medicine.Transcription factor-DNA binding: beyond binding site motifs.Challenges and progress in interpretation of non-coding genetic variants associated with human disease.Recent advances in high-throughput approaches to dissect enhancer functionConstraints on eQTL Fine Mapping in the Presence of Multisite Local Regulation of Gene Expression.Genome-scale high-resolution mapping of activating and repressive nucleotides in regulatory regions.Systematic identification of regulatory variants associated with cancer risk.QuASAR-MPRA: Accurate allele-specific analysis for massively parallel reporter assays.Quantifying the regulatory effect size of cis-acting genetic variation using allelic fold change.Variant Interpretation: Functional Assays to the Rescue.The effect of genetic variation on promoter usage and enhancer activity.Cis-regulatory landscapes of four cell types of the retina.A Dementia-Associated Risk Variant near TMEM106B Alters Chromatin Architecture and Gene Expression.Functional role of PLCE1 intronic insertion variant associated with susceptibility to esophageal squamous-cell carcinoma.A genome-wide interactome of DNA-associated proteins in the human liver.Context-specific effects of genetic variants associated with autoimmune disease.Resolving systematic errors in widely used enhancer activity assays in human cells.Lessons from ten years of genome-wide association studies of asthma.Identification of Single Nucleotide Non-coding Driver Mutations in Cancer.Integrative analysis of omics summary data reveals putative mechanisms underlying complex traits.A novel k-mer set memory (KSM) motif representation improves regulatory variant prediction.Emerging applications of genome-editing technology to examine functionality of GWAS-associated variants for complex traits.Large, Diverse Population Cohorts of hiPSCs and Derived Hepatocyte-like Cells Reveal Functional Genetic Variation at Blood Lipid-Associated Loci.Assessing sufficiency and necessity of enhancer activities for gene expression and the mechanisms of transcription activation.Methods for fine-mapping with chromatin and expression data.Functional genomics and assays of regulatory activity detect mechanisms at loci for lipid traits and coronary artery disease.Cellular network perturbations by disease-associated variants.
P2860
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P2860
Direct Identification of Hundreds of Expression-Modulating Variants using a Multiplexed Reporter Assay.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
Direct Identification of Hundr ...... a Multiplexed Reporter Assay.
@ast
Direct Identification of Hundr ...... a Multiplexed Reporter Assay.
@en
type
label
Direct Identification of Hundr ...... a Multiplexed Reporter Assay.
@ast
Direct Identification of Hundr ...... a Multiplexed Reporter Assay.
@en
prefLabel
Direct Identification of Hundr ...... a Multiplexed Reporter Assay.
@ast
Direct Identification of Hundr ...... a Multiplexed Reporter Assay.
@en
P2093
P2860
P50
P1433
P1476
Direct Identification of Hundr ...... a Multiplexed Reporter Assay.
@en
P2093
Brandon Liu
Daniel S Park
Dylan Kotliar
Ryan Tewhey
Sarah Winnicki
Steven K Reilly
Tarjei S Mikkelsen
P2860
P304
P356
10.1016/J.CELL.2016.04.027
P407
P577
2016-06-01T00:00:00Z