Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway. - Wikidata - awgldk - TriplyDB

Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway.

Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway.

http://www.wikidata.org/entity/Q36043181

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Nutrient deprivation induces α-synuclein aggregation through endoplasmic reticulum stress response and SREBP2 pathway Protein degradation pathways in Parkinson's disease: curse or blessing Alpha-Synuclein Oligomers-Neurotoxic Molecules in Parkinson's Disease and Other Lewy Body Disorders Generation of SNCA Cell Models Using Zinc Finger Nuclease (ZFN) Technology for Efficient High-Throughput Drug Screening Time course and progression of wild type α-synuclein accumulation in a transgenic mouse model.Molecular chaperones and protein folding as therapeutic targets in Parkinson's disease and other synucleinopathies α-Synuclein impairs oligodendrocyte progenitor maturation in multiple system atrophy ATP6V0C knockdown in neuroblastoma cells alters autophagy-lysosome pathway function and metabolism of proteins that accumulate in neurodegenerative disease.Systematic comparison of the effects of alpha-synuclein mutations on its oligomerization and aggregation.Overexpression of alpha-synuclein at non-toxic levels increases dopaminergic cell death induced by copper exposure via modulation of protein degradation pathways.Autophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment.shRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act as Genetic Modifiers of Alpha-Synuclein Aggregation, Secretion and Toxicity.Review: Novel treatment strategies targeting alpha-synuclein in multiple system atrophy as a model of synucleinopathy ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons.GBA deficiency promotes SNCA/α-synuclein accumulation through autophagic inhibition by inactivated PPP2A.Inhibition of Protein Ubiquitination by Paraquat and 1-Methyl-4-Phenylpyridinium Impairs Ubiquitin-Dependent Protein Degradation Pathways.Studying neurodegenerative diseases in culture models.Oligodendroglia and Myelin in Neurodegenerative Diseases: More Than Just Bystanders?Congenital disorders of autophagy: an emerging novel class of inborn errors of neuro-metabolism.α-Synuclein in Extracellular Vesicles: Functional Implications and Diagnostic Opportunities.Sestrin2 Protects Dopaminergic Cells against Rotenone Toxicity through AMPK-Dependent Autophagy Activation.(Poly)phenols protect from α-synuclein toxicity by reducing oxidative stress and promoting autophagy.The small GTPase Rab11 co-localizes with α-synuclein in intracellular inclusions and modulates its aggregation, secretion and toxicity.Number and Brightness analysis of alpha-synuclein oligomerization and the associated mitochondrial morphology alterations in live cells.The emerging role of autophagic-lysosomal dysfunction in Gaucher disease and Parkinson's disease.Anti-aging treatments slow propagation of synucleinopathy by restoring lysosomal function.Alpha-synuclein prevents the formation of spherical mitochondria and apoptosis under oxidative stress Mutations in LRRK2 potentiate age-related impairment of autophagic flux.Posttranslational modification and mutation of histidine 50 trigger alpha synuclein aggregation and toxicity.Overexpression of synphilin-1 promotes clearance of soluble and misfolded alpha-synuclein without restoring the motor phenotype in aged A30P transgenic mice.MicroRNA-101 Modulates Autophagy and Oligodendroglial Alpha-Synuclein Accumulation in Multiple System Atrophy.The neuropathology of multiple system atrophy and its therapeutic implications.Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype.The lysosomal enzyme alpha-Galactosidase A is deficient in Parkinson's disease brain in association with the pathologic accumulation of alpha-synuclein.Multiple system atrophy: experimental models and reality.Familial knockin mutation of LRRK2 causes lysosomal dysfunction and accumulation of endogenous insoluble α-synuclein in neurons.Lewy Bodies and the Mechanisms of Neuronal Cell Death in Parkinson's Disease and Dementia with Lewy Bodies.Boosting chaperone-mediated autophagy in vivo mitigates α-synuclein-induced neurodegeneration.Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies.In vitro models of multiple system atrophy from primary cells to induced pluripotent stem cells.

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Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway.

http://www.wikidata.org/entity/Q36043181

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name

Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway.

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Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway.

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Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway.

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Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway.

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Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway.

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Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway.

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Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway.

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Anne-Maria Poehler

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Jacqueline Schneider

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Jochen Klucken

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Juergen Winkler

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Pamela J McLean

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P2860

Progressive accumulation of amyloid-beta oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins

Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy

Alpha-synuclein in Lewy bodies

Chaperone-mediated autophagy markers in Parkinson disease brains

Interaction of alpha-synuclein and synphilin-1: effect of Parkinson's disease-associated mutations

The roles of intracellular protein-degradation pathways in neurodegeneration

Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

Molecular pathways of neurodegeneration in Parkinson's disease

Potential therapeutic applications of autophagy

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10.4161/AUTO.19371

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5

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8

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Eliezer Masliah

Edward Rockenstein

Darius Ebrahimi-Fakhari

Ursula Schlötzer-Schrehardt

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2012-05-01T00:00:00Z

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3378419

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