Full-length IL-33 promotes inflammation but not Th2 response in vivo in an ST2-independent fashion - Wikidata - awgldk - TriplyDB

Full-length IL-33 promotes inflammation but not Th2 response in vivo in an ST2-independent fashion

Full-length IL-33 promotes inflammation but not Th2 response in vivo in an ST2-independent fashion

http://www.wikidata.org/entity/Q36054682

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The IL-1 cytokine family and its role in inflammation and fibrosis in the lung Emerging Endotypes of Chronic Rhinosinusitis and Its Application to Precision Medicine.Role of IL-33 and its receptor in T cell-mediated autoimmune diseases Interleukin 33: a switch-hitting cytokine.Alarmin IL-33 acts as an immunoadjuvant to enhance antigen-specific tumor immunity Associations between genetic polymorphisms in IL-33, IL1R1 and risk for inflammatory bowel disease.The anti-atherogenic cytokine interleukin-33 inhibits the expression of a disintegrin and metalloproteinase with thrombospondin motifs-1, -4 and -5 in human macrophages: Requirement of extracellular signal-regulated kinase, c-Jun N-terminal kinase a IL-25 and IL-33 Contribute to Development of Eosinophilic Airway Inflammation in Epicutaneously Antigen-Sensitized Mice Molecular adjuvant IL-33 enhances the potency of a DNA vaccine in a lethal challenge model A potential role for interleukin-33 and γ-epithelium sodium channel in the pathogenesis of human malaria associated lung injury.Upregulation of interleukin-33 and thymic stromal lymphopoietin levels in the lungs of idiopathic pulmonary fibrosis Conjunctival Goblet Cell Function: Effect of Contact Lens Wear and Cytokines.Group 2 innate lymphoid cells utilize the IRF4-IL-9 module to coordinate epithelial cell maintenance of lung homeostasis Interleukin-33 enhances programmed oncosis of ST2L-positive low-metastatic cells in the tumour microenvironment of lung cancer.Disease severity in K/BxN serum transfer-induced arthritis is not affected by IL-33 deficiency.Elevated expression of NEU1 sialidase in idiopathic pulmonary fibrosis provokes pulmonary collagen deposition, lymphocytosis, and fibrosis.Interleukin-33 potentiates bleomycin-induced lung injury.IFN-γ directly controls IL-33 protein level through a STAT1- and LMP2-dependent mechanism.Interleukin-33: a mediator of inflammation targeting hematopoietic stem and progenitor cells and their progenies.The potential role of IL-33/ST2 signaling in fibrotic diseases.Inflammasome activation and function in liver disease.Regulation of IL-33 by Oncostatin M in Mouse Lung Epithelial Cells.The TLR4-TRIF pathway can protect against the development of experimental allergic asthma.IL-33 Promotes Gastric Cancer Cell Invasion and Migration Via ST2-ERK1/2 Pathway.IL-33 isoforms: their future as vaccine adjuvants?Interleukin-33/ST2 axis promotes breast cancer growth and metastases by facilitating intratumoral accumulation of immunosuppressive and innate lymphoid cells.IL-33 promotes innate IFN-γ production and modulates dendritic cell response in LCMV-induced hepatitis in mice Interleukin-33 promotes inflammation-induced lymphangiogenesis via ST2/TRAF6-mediated Akt/eNOS/NO signalling pathway.IL-25, IL-33 and TSLP receptor are not critical for development of experimental murine malaria.Cytokines in chronic respiratory diseases.A Dataset of 26 Candidate Gene and Pro-Inflammatory Cytokine Variants for Association Studies in Idiopathic Pulmonary Fibrosis: Frequency Distribution in Normal Czech Population.Evidence for a regulatory loop between IFN-γ and IL-33 in skin inflammation.The full-length interleukin-33 (FLIL33)-importin-5 interaction does not regulate nuclear localization of FLIL33 but controls its intracellular degradation.Interleukin-33 exacerbates acute colitis via interleukin-4 in mice.Innate Lymphoid Cells: A Promising New Regulator in Fibrotic Diseases.Pathogenesis of Recalcitrant Chronic Rhinosinusitis: The Emerging Role of Innate Immune Cells.The IL-33 Receptor ST2 Regulates Pulmonary Inflammation and Fibrosis to Bleomycin.IL-33/ST2 Axis in Organ Fibrosis IL-33 facilitates proliferation of colorectal cancer dependent on COX2/PGE

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Full-length IL-33 promotes inflammation but not Th2 response in vivo in an ST2-independent fashion

http://www.wikidata.org/entity/Q36054682

description

2012 nî lūn-bûn

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Full-length IL-33 promotes inf ...... in an ST2-independent fashion

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JIMMUNOL.1200259

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Journal of Immunology

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Full-length IL-33 promotes inf ...... in an ST2-independent fashion

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Edward M Pickering

http://www.w3.org/2001/XMLSchema#string

Irina G Luzina

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John C Papadimitriou

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Nevins W Todd

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Pavel Kopach

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Phillip H Kang

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Sergei P Atamas

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Virginia Lockatell

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P2860

IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines

The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1

T1/ST2 is preferentially expressed on murine Th2 cells, independent of interleukin 4, interleukin 5, and interleukin 10, and important for Th2 effector function

The dual function cytokine IL-33 interacts with the transcription factor NF-κB to dampen NF-κB-stimulated gene transcription

Increased expression of IL-33 in severe asthma: evidence of expression by airway smooth muscle cells.

Differential expression of tissue repair genes in the pathogenesis of chronic obstructive pulmonary disease.

Interleukin-33 contributes to both M1 and M2 chemokine marker expression in human macrophages.

Activated, but not resting human Th2 cells, in contrast to Th1 and T regulatory cells, produce soluble ST2 and express low levels of ST2L at the cell surface.

IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo.

Complex regulation of pulmonary inflammation and fibrosis by CCL18

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403-410

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scholarly article

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10.4049/JIMMUNOL.1200259

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1

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189

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Andrew N. J. McKenzie

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2012-05-25T00:00:00Z

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225064033

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22634619

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3381874

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