Prediction of drug metabolism and interactions on the basis of in vitro investigations.
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Drug Metabolism - From In Vitro to In Vivo, From Simple to Complex: Reflections of the BCPT Nordic Prize 2014 AwardeeAnalytical tools and approaches for metabolite identification in early drug discovery.Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010.Tissue-level modeling of xenobiotic metabolism in liver: An emerging tool for enabling clinical translational researchA high-throughput inhibition screening of major human cytochrome P450 enzymes using an in vitro cocktail and liquid chromatography-tandem mass spectrometry.Simultaneous determination of bupropion, metroprolol, midazolam, phenacetin, omeprazole and tolbutamide in rat plasma by UPLC-MS/MS and its application to cytochrome P450 activity study in rats.Strategies to assess the drug interaction potential in translational medicine.In vitro-in vivo extrapolation of hepatic clearance: biological tools, scaling factors, model assumptions and correct concentrations.Physiologically based approaches towards the prediction of pharmacokinetics: in vitro-in vivo extrapolation.Online electrochemistry/mass spectrometry in drug metabolism studies: principles and applications.From known knowns to known unknowns: predicting in vivo drug metabolites.An evaluation of the latest in vitro tools for drug metabolism studies.Tackling multidrug resistance mediated by efflux transporters in tumor-initiating cells.Drug Metabolism in Preclinical Drug Development: A Survey of the Discovery Process, Toxicology, and Computational Tools.In vivo-in vitro-in silico pharmacokinetic modelling in drug development: current status and future directions.How to Choose In Vitro Systems to Predict In Vivo Drug Clearance: A System Pharmacology Perspective.Effect of ademetionine on cytochrome P450 isoforms activity in rats.Toxicity, pharmacokinetics and metabolism of a novel inhibitor of IL-6-induced STAT3 activation.In vitro inhibition of human CYP1A2, CYP2D6, and CYP3A4 by six herbs commonly used in pregnancy.Interspecies variation in phase I metabolism of bufalin in hepatic microsomes from mouse, rat, dog, minipig, monkey, and human.Existing approaches incorporating replacement, reduction and refinement of animal testing: applicability in food and feed risk assessmentIs zebrafish (Danio rerio) a tool for human-like metabolism study?
P2860
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P2860
Prediction of drug metabolism and interactions on the basis of in vitro investigations.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Prediction of drug metabolism and interactions on the basis of in vitro investigations.
@ast
Prediction of drug metabolism and interactions on the basis of in vitro investigations.
@en
type
label
Prediction of drug metabolism and interactions on the basis of in vitro investigations.
@ast
Prediction of drug metabolism and interactions on the basis of in vitro investigations.
@en
prefLabel
Prediction of drug metabolism and interactions on the basis of in vitro investigations.
@ast
Prediction of drug metabolism and interactions on the basis of in vitro investigations.
@en
P2093
P2860
P1476
Prediction of drug metabolism and interactions on the basis of in vitro investigations
@en
P2093
Arja Rautio
Hannu Raunio
Jouko Uusitalo
Olavi Pelkonen
P2860
P304
P356
10.1111/J.1742-7843.2005.PTO960305.X
P577
2005-03-01T00:00:00Z