Rapid development of exhaustion and down-regulation of eomesodermin limit the antitumor activity of adoptively transferred murine natural killer cells. - Wikidata - awgldk - TriplyDB

Rapid development of exhaustion and down-regulation of eomesodermin limit the antitumor activity of adoptively transferred murine natural killer cells.

Rapid development of exhaustion and down-regulation of eomesodermin limit the antitumor activity of adoptively transferred murine natural killer cells.

http://www.wikidata.org/entity/Q36057599

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T-bet and Eomesodermin in NK Cell Development, Maturation, and Function Positive and negative regulation by NK cells in cancer Natural Killer Cells in Graft-versus-Host-Disease after Allogeneic Hematopoietic Cell Transplantation.Reversal of NK-cell exhaustion in advanced melanoma by Tim-3 blockade.Adaptations of Natural Killer Cells to Self-MHC Class I.CALGB 150905 (Alliance): rituximab broadens the antilymphoma response by activating unlicensed NK cells.Antigen presenting cell-mediated expansion of human umbilical cord blood yields log-scale expansion of natural killer cells with anti-myeloma activity.Cytokine therapy reverses NK cell anergy in MHC-deficient tumors Mechanisms of interferon-γ production by neutrophils and its function during Streptococcus pneumoniae pneumonia.Combined IL-15 and IL-12 drives the generation of CD34(+)-derived natural killer cells with superior maturation and alloreactivity potential following adoptive transfer IL-12/15/18-preactivated NK cells suppress GvHD in a mouse model of mismatched hematopoietic cell transplantation Interaction of natural killer cells with neutrophils exerts a significant antitumor immunity in hematopoietic stem cell transplantation recipients Cytokine activation induces human memory-like NK cells NK Cell-Mediated Antitumor Effects of a Folate-Conjugated Immunoglobulin Are Enhanced by Cytokines A novel TLR7 agonist reverses NK cell anergy and cures RMA-S lymphoma-bearing mice Retargeting NK-92 cells by means of CD19- and CD20-specific chimeric antigen receptors compares favorably with antibody-dependent cellular cytotoxicity.Anti-KIR antibody enhancement of anti-lymphoma activity of natural killer cells as monotherapy and in combination with anti-CD20 antibodies.In Vivo Efficacy of Umbilical Cord Blood Stem Cell-Derived NK Cells in the Treatment of Metastatic Colorectal Cancer.PD-1 mediates functional exhaustion of activated NK cells in patients with Kaposi sarcoma.The anti-tumor role of NK cells in vivo pre-activated and re-stimulated by interleukins in acute lymphoblastic leukemia.NK cell function is markedly impaired in patients with chronic lymphocytic leukaemia but is preserved in patients with small lymphocytic lymphoma.Phenotype of NK-Like CD8(+) T Cells with Innate Features in Humans and Their Relevance in Cancer Diseases.Transcription factors involved in the regulation of natural killer cell development and function: an update.Umbilical cord blood graft engineering: challenges and opportunities.The Rise of Allogeneic Natural Killer Cells As a Platform for Cancer Immunotherapy: Recent Innovations and Future Developments.GVHD prevents NK-cell-dependent leukemia and virus-specific innate immunity.Modulation of innate immunity in the tumor microenvironment.Acute myeloid leukemia impairs natural killer cells through the formation of a deficient cytotoxic immunological synapse.IgG1 anti-epidermal growth factor receptor antibodies induce CD8-dependent antitumor activity.What Fuels Natural Killers? Metabolism and NK Cell Responses NK Cell Exhaustion.Persistent infection due to a small-colony variant of Burkholderia pseudomallei leads to PD-1 upregulation on circulating immune cells and mononuclear infiltration in viscera of experimental BALB/c mice.Murine NK cell intrinsic cytokine-induced memory-like responses are maintained following homeostatic proliferation Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells.NK Cell Functional Impairment after Allogeneic Hematopoietic Stem Cell Transplantation Is Associated with Reduced Levels of T-bet and Eomesodermin.The breast tumor microenvironment alters the phenotype and function of natural killer cells The transcription Factor AHR prevents the differentiation of a stage 3 innate lymphoid cell subset to natural killer cells.NK cell exhaustion: bad news for chronic disease?Reversal of natural killer cell exhaustion by TIM-3 blockade.Monocyte/macrophage-elicited natural killer cell dysfunction in hepatocellular carcinoma is mediated by CD48/2B4 interactions.

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Rapid development of exhaustion and down-regulation of eomesodermin limit the antitumor activity of adoptively transferred murine natural killer cells.

http://www.wikidata.org/entity/Q36057599

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Alysha De Souza

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P2860

Control of effector CD8+ T cell function by the transcription factor Eomesodermin

Up on the tightrope: natural killer cell activation and inhibition

Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer

T cell exhaustion

NKAML: a pilot study to determine the safety and feasibility of haploidentical natural killer cell transplantation in childhood acute myeloid leukemia.

NK cells mediate reduction of GVHD by inhibiting activated, alloreactive T cells while retaining GVT effects.

Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b.

Tissue-specific homing and expansion of donor NK cells in allogeneic bone marrow transplantation.

Bortezomib Treatment to Potentiate the Anti-tumor Immunity of Ex-vivo Expanded Adoptively Infused Autologous Natural Killer Cells

Human breast cancer cells enhance self tolerance by promoting evasion from NK cell antitumor immunity.

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