Translational and Early Phase Strategies for Treatment Development: Report of ISCTM Autumn 2013 Symposium.

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Leveraging a Sturge-Weber Gene Discovery: An Agenda for Future Research.

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Translational and Early Phase Strategies for Treatment Development: Report of ISCTM Autumn 2013 Symposium.

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Translational and Early Phase ...... f ISCTM Autumn 2013 Symposium.

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Bruce J Kinon

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Douglas E Feltner

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Geert J Groeneveld

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Jared W Young

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Mike F Egan

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Steve Riley

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William Z Potter

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P2860

Modulation of prepulse inhibition and stereotypies in rodents: no evidence for antipsychotic-like properties of histamine H3-receptor inverse agonists.

Research Domain Criteria: cognitive systems, neural circuits, and dimensions of behavior.

Histamine H3 receptor antagonists: preclinical promise for treating obesity and cognitive disorders.

Morphine and ibuprofen compared using the cold pressor test.

Effects of the histamine H₃ receptor antagonist ABT-239 on cognition and nicotine-induced memory enhancement in mice.

Pilot randomized controlled study of a histamine receptor inverse agonist in the symptomatic treatment of AD.

Randomized crossover study of the histamine H3 inverse agonist MK-0249 for the treatment of cognitive impairment in patients with schizophrenia.

Preclinical evaluation of non-imidazole histamine H3 receptor antagonists in comparison to atypical antipsychotics for the treatment of cognitive deficits associated with schizophrenia.

Alfentanil and placebo analgesia: no sex differences detected in models of experimental pain.

Alertness and psychomotor performance effects of the histamine-3 inverse agonist MK-0249 in obstructive sleep apnea patients on continuous positive airway pressure therapy with excessive daytime sleepiness: a randomized adaptive crossover study.

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Translational and Early Phase Strategies for Treatment Development: Report of ISCTM Autumn 2013 Symposium.

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P2860

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Translational and Early Phase Strategies for Treatment Development: Report of ISCTM Autumn 2013 Symposium.

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