Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts. - Wikidata - awgldk - TriplyDB

Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts.

Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts.

http://www.wikidata.org/entity/Q36066234

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Mitochondrial Stat3, the Need for Design Thinking The consequences of selective inhibition of signal transducer and activator of transcription 3 (STAT3) tyrosine705 phosphorylation by phosphopeptide mimetic prodrugs targeting the Src homology 2 (SH2) domain Targeting SH2 domains in breast cancer STAT3 inhibitors for cancer therapy: Have all roads been explored?A small molecule inhibitor of ETV1, YK-4-279, prevents prostate cancer growth and metastasis in a mouse xenograft model Brevilin A, a novel natural product, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells The anthelmintic drug niclosamide induces apoptosis, impairs metastasis and reduces immunosuppressive cells in breast cancer model Identification of STAT1 and STAT3 specific inhibitors using comparative virtual screening and docking validation Signal transducer and activator of transcription 3 (STAT3) inhibitor, S3I-201, acts as a potent and non-selective alkylating agent Discovery of monocarbonyl curcumin-BTP hybrids as STAT3 inhibitors for drug-sensitive and drug-resistant breast cancer therapy.Therapeutic modulators of STAT signalling for human diseases HCV infection enhances Th17 commitment, which could affect the pathogenesis of autoimmune diseases.Transcription Factor STAT3 as a Novel Molecular Target for Cancer Prevention.Alteration of SHP-1/p-STAT3 Signaling: A Potential Target for Anticancer Therapy.Involvement of the janus kinase/signal transducer and activator of transcription signaling pathway in multiple sclerosis and the animal model of experimental autoimmune encephalomyelitis.Identification of novel inhibitors that disrupt STAT3-DNA interaction from a γ-AApeptide OBOC combinatorial library The oncogenic potential of human cytomegalovirus and breast cancer.Withacnistin inhibits recruitment of STAT3 and STAT5 to growth factor and cytokine receptors and induces regression of breast tumours Withaferin A Inhibits STAT3 and Induces Tumor Cell Death in Neuroblastoma and Multiple Myeloma Changes in signal transducer and activator of transcription 3 (STAT3) dynamics induced by complexation with pharmacological inhibitors of Src homology 2 (SH2) domain dimerization.Progress towards the development of SH2 domain inhibitors.Pancreatic T cell protein-tyrosine phosphatase deficiency affects beta cell function in mice Aberrantly activated pSTAT3-Ser727 in human endometrial cancer is suppressed by HO-3867, a novel STAT3 inhibitor.HO-3867, a safe STAT3 inhibitor, is selectively cytotoxic to ovarian cancer.Targeting survivin in cancer: novel drug development approaches.Protein kinase C zeta regulates human pancreatic cancer cell transformed growth and invasion through a STAT3-dependent mechanism Development of new N-Arylbenzamides as STAT3 Dimerization Inhibitors.Combined STAT3 and BCR-ABL1 inhibition induces synthetic lethality in therapy-resistant chronic myeloid leukemia A novel small-molecule inhibitor of hepatitis C virus replication acts by suppressing signal transducer and activator of transcription 3.A Resveratrol Analogue Promotes ERKMAPK-Dependent Stat3 Serine and Tyrosine Phosphorylation Alterations and Antitumor Effects In Vitro against Human Tumor Cells.STAT3 pathway regulates lung-derived brain metastasis initiating cell capacity through miR-21 activation.Hirsutinolide Series Inhibit Stat3 Activity, Alter GCN1, MAP1B, Hsp105, G6PD, Vimentin, TrxR1, and Importin α-2 Expression, and Induce Antitumor Effects against Human Glioma.Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth.A novel nuclear Src and p300 signaling axis controls migratory and invasive behavior in pancreatic cancer.CD133+ brain tumor-initiating cells are dependent on STAT3 signaling to drive medulloblastoma recurrence.Identification of a natural product-like STAT3 dimerization inhibitor by structure-based virtual screening.High Glucose-Mediated STAT3 Activation in Endometrial Cancer Is Inhibited by Metformin: Therapeutic Implications for Endometrial Cancer.Regulation of the JMJD3 (KDM6B) histone demethylase in glioblastoma stem cells by STAT3 Inhibition of STAT3 activity delays obesity-induced thyroid carcinogenesis in a mouse model.Hydroxamic Acid and Benzoic Acid-Based STAT3 Inhibitors Suppress Human Glioma and Breast Cancer Phenotypes In Vitro and In Vivo.

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Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts.

http://www.wikidata.org/entity/Q36066234

description

2012 nî lūn-bûn

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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2012年论文

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2012年论文

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name

Orally bioavailable small-mole ...... st and lung cancer xenografts.

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Orally bioavailable small-mole ...... st and lung cancer xenografts.

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type

label

Orally bioavailable small-mole ...... st and lung cancer xenografts.

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Orally bioavailable small-mole ...... st and lung cancer xenografts.

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Orally bioavailable small-mole ...... st and lung cancer xenografts.

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Orally bioavailable small-mole ...... st and lung cancer xenografts.

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Proceedings of the National Academy of Sciences of the United States of America

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Orally bioavailable small-mole ...... st and lung cancer xenografts.

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Andrew T Namanja

http://www.w3.org/2001/XMLSchema#string

Brent D G Page

http://www.w3.org/2001/XMLSchema#string

David Paladino

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James Turkson

http://www.w3.org/2001/XMLSchema#string

Jihe Zhao

http://www.w3.org/2001/XMLSchema#string

Patrick T Gunning

http://www.w3.org/2001/XMLSchema#string

Peibin Yue

http://www.w3.org/2001/XMLSchema#string

Tianshu Li

http://www.w3.org/2001/XMLSchema#string

Wei Zhao

http://www.w3.org/2001/XMLSchema#string

Xiaolei Zhang

http://www.w3.org/2001/XMLSchema#string

P2860

Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors.

Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer

Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation

STATs in cancer inflammation and immunity: a leading role for STAT3

Stat3 as an oncogene

Requirement for Ras/Rac1-mediated p38 and c-Jun N-terminal kinase signaling in Stat3 transcriptional activity induced by the Src oncoprotein.

Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cells

Isoform selective inhibition of STAT1 or STAT3 homo-dimerization via peptidomimetic probes: structural recognition of STAT SH2 domains.

Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity.

Do serum biomarkers really measure breast cancer?

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9623-9628

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10.1073/PNAS.1121606109

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24

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109

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225059187

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22623533

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3386073

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