New insights into the mechanism of Alzheimer amyloid-beta fibrillogenesis inhibition by N-methylated peptides.
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Flexibility and binding affinity in protein-ligand, protein-protein and multi-component protein interactions: limitations of current computational approaches.Finite size effects in simulations of protein aggregation.Formation and growth of oligomers: a Monte Carlo study of an amyloid tau fragmentMolecular structures of quiescently grown and brain-derived polymorphic fibrils of the Alzheimer amyloid abeta9-40 peptide: a comparison to agitated fibrils.Computational backbone mutagenesis of Abeta peptides: probing the role of backbone hydrogen bonds in aggregation.Carbon nanotube inhibits the formation of β-sheet-rich oligomers of the Alzheimer's amyloid-β(16-22) peptide.Probing the efficacy of peptide-based inhibitors against acid- and zinc-promoted oligomerization of amyloid-β peptide via single-oligomer spectroscopySpontaneous formation of twisted Aβ(16-22) fibrils in large-scale molecular-dynamics simulations.Effects of peptides derived from terminal modifications of the aβ central hydrophobic core on aβ fibrillization.All-atom computer simulations of amyloid fibrils disaggregation.Protein folding and aggregation into amyloid: the interference by natural phenolic compoundsThe binding of thioflavin T and its neutral analog BTA-1 to protofibrils of the Alzheimer's disease Abeta(16-22) peptide probed by molecular dynamics simulationsWhat determines the structure and stability of KFFE monomers, dimers, and protofibrils?The butyrylcholinesterase K variant confers structurally derived risks for Alzheimer pathology.The use of mass spectrometry to study amyloid-β peptides.The role of molecular simulations in the development of inhibitors of amyloid β-peptide aggregation for the treatment of Alzheimer's diseaseMolecular understanding of a potential functional link between antimicrobial and amyloid peptides.Keampferol-3-O-rhamnoside abrogates amyloid beta toxicity by modulating monomers and remodeling oligomers and fibrils to non-toxic aggregatesInsights into stability and toxicity of amyloid-like oligomers by replica exchange molecular dynamics analyses.Role of water in mediating the assembly of Alzheimer amyloid-beta Abeta16-22 protofilaments.Structure-activity relationships in peptide modulators of β-amyloid protein aggregation: variation in α,α-disubstitution results in altered aggregate size and morphology9,10-Anthraquinone hinders beta-aggregation: how does a small molecule interfere with Abeta-peptide amyloid fibrillation?Strategy to discover full-length amyloid-beta peptide ligands using high-efficiency microarray technology.Design of a Molecular Hybrid of Dual Peptide Inhibitors Coupled on AuNPs for Enhanced Inhibition of Amyloid β-Protein Aggregation and Cytotoxicity.The inhibitory mechanism of a fullerene derivative against amyloid-β peptide aggregation: an atomistic simulation study.Kamikihi-to (KKT) rescues axonal and synaptic degeneration associated with memory impairment in a mouse model of Alzheimer's disease, 5XFAD.An adaptive bias - hybrid MD/kMC algorithm for protein folding and aggregation.Carnosine inhibits Aβ(42) aggregation by perturbing the H-bond network in and around the central hydrophobic cluster.Ac-LPFFD-Th: A Trehalose-Conjugated Peptidomimetic as a Strong Suppressor of Amyloid-β Oligomer Formation and Cytotoxicity.Exploring the Mechanism of Inhibition of Au Nanoparticles on the Aggregation of Amyloid-β(16-22) Peptides at the Atom Level by All-Atom Molecular Dynamics.
P2860
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P2860
New insights into the mechanism of Alzheimer amyloid-beta fibrillogenesis inhibition by N-methylated peptides.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
New insights into the mechanis ...... tion by N-methylated peptides.
@ast
New insights into the mechanis ...... tion by N-methylated peptides.
@en
type
label
New insights into the mechanis ...... tion by N-methylated peptides.
@ast
New insights into the mechanis ...... tion by N-methylated peptides.
@en
prefLabel
New insights into the mechanis ...... tion by N-methylated peptides.
@ast
New insights into the mechanis ...... tion by N-methylated peptides.
@en
P2093
P2860
P1433
P1476
New insights into the mechanis ...... tion by N-methylated peptides.
@en
P2093
Joan-Emma Shea
Mary A Griffin
Patricia Soto
P2860
P304
P356
10.1529/BIOPHYSJ.107.112086
P407
P577
2007-07-13T00:00:00Z