Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH2-terminal kinase activation, and defects in AP-1 transcriptional activity.
about
NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathwayThe JIP group of mitogen-activated protein kinase scaffold proteinsHuman mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activated by environmental stresses and physiological stimuliInteraction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3Activation of the Jnk signaling pathway by a dual-specificity phosphatase, JSP-1MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokinesRole of MEKK2-MEK5 in the regulation of TNF-alpha gene expression and MEKK2-MKK7 in the activation of c-Jun N-terminal kinase in mast cellsMolecular cloning and characterization of human JNKK2, a novel Jun NH2-terminal kinase-specific kinaseMitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinaseCdc42: An essential Rho-type GTPase controlling eukaryotic cell polarity.Identification of a motif in the carboxyl terminus of beta -arrestin2 responsible for activation of JNK3Identification of c-Jun NH2-terminal protein kinase (JNK)-activating kinase 2 as an activator of JNK but not p38Differential activation of two JNK activators, MKK7 and SEK1, by MKN28-derived nonreceptor serine/threonine kinase/mixed lineage kinase 2The MKK7 gene encodes a group of c-Jun NH2-terminal kinase kinasesDeficiency of the stress kinase p38alpha results in embryonic lethality: characterization of the kinase dependence of stress responses of enzyme-deficient embryonic stem cellsThe protein kinase PKR is required for p38 MAPK activation and the innate immune response to bacterial endotoxinA Caenorhabditis elegans MAP kinase kinase, MEK-1, is involved in stress responsesjkk-1 and mek-1 regulate body movement coordination and response to heavy metals through jnk-1 in Caenorhabditis elegansA RNA interference screen identifies the protein phosphatase 2A subunit PR55gamma as a stress-sensitive inhibitor of c-SRCRequirement of the JIP1 scaffold protein for stress-induced JNK activationA lupus-like syndrome develops in mice lacking the Ro 60-kDa protein, a major lupus autoantigenRequirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expressionDefective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient miceConcentration-dependent positive and negative regulation of a MAP kinase by a MAP kinase kinaseMolecular cloning of multiple splicing variants of JIP-1 preferentially expressed in brainJNK2 translocates to the mitochondria and mediates cytochrome c release in PC12 cells in response to 6-hydroxydopamineEssential role for p38alpha mitogen-activated protein kinase in placental angiogenesisActivation of c-Jun N-terminal kinase 1 by UV irradiation is inhibited by wortmannin without affecting c-iun expressionSelective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6JNK/SAPK Signaling Is Essential for Efficient Reprogramming of Human Fibroblasts to Induced Pluripotent Stem CellsMatrix survival signaling: from fibronectin via focal adhesion kinase to c-Jun NH(2)-terminal kinase.Induction of Macrophage Function in Human THP-1 Cells Is Associated with Rewiring of MAPK Signaling and Activation of MAP3K7 (TAK1) Protein KinaseGlycogen synthase kinase 3beta and extracellular signal-regulated kinase inactivate heat shock transcription factor 1 by facilitating the disappearance of transcriptionally active granules after heat shockThe Drosophila p38 MAPK pathway is required during oogenesis for egg asymmetric development.Analysis of the mitogen-activated protein kinase kinase 4 (MAP2K4) tumor suppressor gene in ovarian cancer.Gene transfer of the JNK interacting protein-1 protects dopaminergic neurons in the MPTP model of Parkinson's disease.MAPK signaling and the kidney.Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo.Loss of oncogenic H-ras-induced cell cycle arrest and p38 mitogen-activated protein kinase activation by disruption of Gadd45a.c-Jun NH2-terminal kinase-mediated signaling is essential for Pseudomonas aeruginosa ExoS-induced apoptosis.
P2860
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P2860
Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH2-terminal kinase activation, and defects in AP-1 transcriptional activity.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Targeted disruption of the MKK ...... AP-1 transcriptional activity.
@ast
Targeted disruption of the MKK ...... AP-1 transcriptional activity.
@en
type
label
Targeted disruption of the MKK ...... AP-1 transcriptional activity.
@ast
Targeted disruption of the MKK ...... AP-1 transcriptional activity.
@en
prefLabel
Targeted disruption of the MKK ...... AP-1 transcriptional activity.
@ast
Targeted disruption of the MKK ...... AP-1 transcriptional activity.
@en
P2093
P2860
P356
P1476
Targeted disruption of the MKK ...... AP-1 transcriptional activity.
@en
P2093
C Tournier
R A Flavell
P2860
P304
P356
10.1073/PNAS.94.7.3004
P407
P577
1997-04-01T00:00:00Z