Distinct roles for long-term hematopoietic stem cells and erythroid precursor cells in a murine model of Jak2V617F-mediated polycythemia vera. - Wikidata - awgldk - TriplyDB

Distinct roles for long-term hematopoietic stem cells and erythroid precursor cells in a murine model of Jak2V617F-mediated polycythemia vera.

Distinct roles for long-term hematopoietic stem cells and erythroid precursor cells in a murine model of Jak2V617F-mediated polycythemia vera.

http://www.wikidata.org/entity/Q36079782

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Self-renewal of single mouse hematopoietic stem cells is reduced by JAK2V617F without compromising progenitor cell expansion Stem and progenitor cell subsets are affected by JAK2 signaling and can be monitored by flow cytometry.Myeloproliferative neoplasms can be initiated from a single hematopoietic stem cell expressing JAK2-V617F.Distinct effects of concomitant Jak2V617F expression and Tet2 loss in mice promote disease progression in myeloproliferative neoplasms.Practical murine hematopathology: a comparative review and implications for research.JAK2 inhibition has different therapeutic effects according to myeloproliferative neoplasm development in mice Depletion of Jak2V617F myeloproliferative neoplasm-propagating stem cells by interferon-α in a murine model of polycythemia vera Loss of Ezh2 cooperates with Jak2V617F in the development of myelofibrosis in a mouse model of myeloproliferative neoplasm.MicroRNAs in myeloproliferative neoplasms.Myeloproliferative neoplasm animal models Hematopoietic stem cells, progenitor cells and leukemic stem cells in adult myeloproliferative neoplasms.Interferon-alpha for the therapy of myeloproliferative neoplasms: targeting the malignant clone.Myeloproliferative neoplasm stem cells.The bone marrow microenvironment as niche retreats for hematopoietic and leukemic stem cells.JAK2 V617F stimulates proliferation of erythropoietin-dependent erythroid progenitors and delays their differentiation by activating Stat1 and other nonerythroid signaling pathways.Jak2V617F driven myeloproliferative neoplasm occurs independently of interleukin-3 receptor beta common signaling.Jak2V617F myeloproliferative neoplasm stem cells and interferon-alpha.Myelofibrosis, JAK2 inhibitors and erythropoiesis.Loss of p53 induces leukemic transformation in a murine model of Jak2 V617F-driven polycythemia vera.Alox5 Blockade Eradicates JAK2V617F-Induced Polycythemia Vera in Mice.Use of the 46/1 haplotype to model JAK2(V617F) clonal architecture in PV patients: clonal evolution and impact of IFNα treatment.

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Distinct roles for long-term hematopoietic stem cells and erythroid precursor cells in a murine model of Jak2V617F-mediated polycythemia vera.

http://www.wikidata.org/entity/Q36079782

description

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2012年の論文

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Distinct roles for long-term h ...... 7F-mediated polycythemia vera.

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Distinct roles for long-term h ...... 7F-mediated polycythemia vera.

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Distinct roles for long-term h ...... 7F-mediated polycythemia vera.

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Ann Mullally

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Benjamin L Ebert

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Fatima Al-Shahrour

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Luke Poveromo

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Rebekka K Schneider

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Steven W Lane

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P2860

JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin

A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor

Efficient in vivo manipulation of mouse genomic sequences at the zygote stage

Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders

WASP: a Web-based Allele-Specific PCR assay designing tool for detecting SNPs and mutations.

Pathological interactions between hematopoietic stem cells and their niche revealed by mouse models of primary myelofibrosis.

Conditional expression of heterozygous or homozygous Jak2V617F from its endogenous promoter induces a polycythemia vera-like disease.

Disease burden at the progenitor level is a feature of primary myelofibrosis: a multivariable analysis of 164 JAK2 V617F-positive myeloproliferative neoplasm patients

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