Impaired antioxidant defence and accumulation of oxidative stress in caspase-2-deficient mice
about
Caspase-2 as a tumour suppressorOld, new and emerging functions of caspases.Caspase-2-mediated cell death is required for deleting aneuploid cells.Caspase-2 promotes obesity, the metabolic syndrome and nonalcoholic fatty liver disease.A nonapoptotic role for CASP2/caspase 2: modulation of autophagy.Caspase-2 maintains bone homeostasis by inducing apoptosis of oxidatively-damaged osteoclasts.An unexpected role for caspase-2 in neuroblastoma.Caspase-2 deficiency promotes aberrant DNA-damage response and genetic instability.Age-related proteostasis and metabolic alterations in Caspase-2-deficient miceBioactive Peptides from Angelica sinensis Protein Hydrolyzate Delay Senescence in Caenorhabditis elegans through Antioxidant Activities.Caspase-2 and the oxidative stress responseSex-specific alterations in glucose homeostasis and metabolic parameters during ageing of caspase-2-deficient miceExtracellular superoxide dismutase deficiency impairs wound healing in advanced age by reducing neovascularization and fibroblast function.Loss of caspase-2 augments lymphomagenesis and enhances genomic instability in Atm-deficient mice.Mutations in CRADD Result in Reduced Caspase-2-Mediated Neuronal Apoptosis and Cause Megalencephaly with a Rare Lissencephaly Variant.Impaired haematopoietic stem cell differentiation and enhanced skewing towards myeloid progenitors in aged caspase-2-deficient mice.Analysis of the minimal specificity of caspase-2 and identification of Ac-VDTTD-AFC as a caspase-2-selective peptide substrate.The tangled circuitry of metabolism and apoptosis.Caspase-2: the reinvented enzyme.Insights into a Critical Role of the FOXO3a-FOXM1 Axis in DNA Damage Response and Genotoxic Drug Resistance.Loss of caspase-2 accelerates age-dependent alterations in mitochondrial production of reactive oxygen speciesCaspase-2 deficiency accelerates chemically induced liver cancer in mice.Caspase-2 protects against oxidative stress in vivo.ER stress does not cause upregulation and activation of caspase-2 to initiate apoptosis.Inhibition of apoptosis signal-regulating kinase 1 enhances endochondral bone formation by increasing chondrocyte survival.Caspase-2 deficiency enhances whole-body carbohydrate utilisation and prevents high-fat diet-induced obesity.Fat, sex and caspase-2.Nucleolar caspase-2: Protecting us from DNA damage.A caspase-2-RFXANK interaction and its implication for MHC class II expression.N-n-Butyl Haloperidol Iodide, a Derivative of the Anti-psychotic Haloperidol, Antagonizes Hypoxia/Reoxygenation Injury by Inhibiting an Egr-1/ROS Positive Feedback Loop in H9c2 Cells.Homozygous null variant in CRADD, encoding an adaptor protein that mediates apoptosis, is associated with lissencephaly.Caspases in metabolic disease and their therapeutic potential.
P2860
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P2860
Impaired antioxidant defence and accumulation of oxidative stress in caspase-2-deficient mice
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Impaired antioxidant defence a ...... ss in caspase-2-deficient mice
@ast
Impaired antioxidant defence a ...... ss in caspase-2-deficient mice
@en
type
label
Impaired antioxidant defence a ...... ss in caspase-2-deficient mice
@ast
Impaired antioxidant defence a ...... ss in caspase-2-deficient mice
@en
prefLabel
Impaired antioxidant defence a ...... ss in caspase-2-deficient mice
@ast
Impaired antioxidant defence a ...... ss in caspase-2-deficient mice
@en
P2093
P2860
P356
P1476
Impaired antioxidant defence a ...... ss in caspase-2-deficient mice
@en
P2093
P2860
P2888
P304
P356
10.1038/CDD.2012.13
P577
2012-02-17T00:00:00Z