Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions. - Wikidata - awgldk - TriplyDB

Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions.

Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions.

http://www.wikidata.org/entity/Q36090294

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The secreted protein S100A7 (psoriasin) is induced by telomere dysfunction in human keratinocytes independently of a DNA damage response and cell cycle regulators Telomerase: The Devil Inside Alternative mechanisms of telomere lengthening: permissive mutations, DNA repair proteins and tumorigenic progression Therapeutic targeting of replicative immortality Lysosome-mediated processing of chromatin in senescence.Acute Inhibition of MEK Suppresses Congenital Melanocytic Nevus Syndrome in a Murine Model Driven by Activated NRAS and Wnt Signaling.A comparison of oncogene-induced senescence and replicative senescence: implications for tumor suppression and aging.PRL-3 promotes telomere deprotection and chromosomal instability.Cellular senescence and protein degradation: breaking down cancer Mechanisms of chromosomal instability in melanoma.Cellular senescence and the senescent secretory phenotype: therapeutic opportunities.Mitochondria are required for pro-ageing features of the senescent phenotype.Stable cellular senescence is associated with persistent DDR activation The presence of telomere fusion in sporadic colon cancer independently of disease stage, TP53/KRAS mutation status, mean telomere length, and telomerase activity Irreparable telomeric DNA damage and persistent DDR signalling as a shared causative mechanism of cellular senescence and ageing.DNA-damage-induced type I interferon promotes senescence and inhibits stem cell function.Rescue from replication stress during mitosis.TP53/p53 alterations and Aurora A expression in progressor and non-progressor colectomies from patients with longstanding ulcerative colitis The role of ATM in the deficiency in nonhomologous end-joining near telomeres in a human cancer cell line.Induction of telomere dysfunction mediated by the telomerase substrate precursor 6-thio-2'-deoxyguanosine.Human umbilical cord matrix stem cells maintain multilineage differentiation abilities and do not transform during long-term culture The replicometer is broken: telomeres activate cellular senescence in response to genotoxic stresses.Emerging roles of the p38 MAPK and PI3K/AKT/mTOR pathways in oncogene-induced senescence.Stn1 is critical for telomere maintenance and long-term viability of somatic human cells.Immortalisation with hTERT Impacts on Sulphated Glycosaminoglycan Secretion and Immunophenotype in a Variable and Cell Specific Manner A primary melanoma and its asynchronous metastasis highlight the role of BRAF, CDKN2A, and TERT Autophagy-independent senescence and genome instability driven by targeted telomere dysfunction.Human RecQ helicases in DNA repair, recombination, and replication.Mechanisms of telomere loss and their consequences for chromosome instability.DNA damage response at telomeres contributes to lung aging and chronic obstructive pulmonary disease.Processing by MRE11 is involved in the sensitivity of subtelomeric regions to DNA double-strand breaks.Senescence-associated Long Non-coding RNA (SALNR) Delays Oncogene-induced Senescence through NF90 Regulation.A three-state model of telomere control over human proliferative boundaries.Effective intra-S checkpoint responses to UVC in primary human melanocytes and melanoma cell lines Non-erythroid alpha spectrin prevents telomere dysfunction after DNA interstrand cross-link damage DNA damage accumulation and TRF2 degradation in atypical Werner syndrome fibroblasts with LMNA mutations.Senescence at a glance Derepression of hTERT gene expression promotes escape from oncogene-induced cellular senescence.Wnt signaling potentiates nevogenesis How unfinished business from S-phase affects mitosis and beyond

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Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions.

http://www.wikidata.org/entity/Q36090294

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Oncogene-induced telomere dysf ...... uman cancer precursor lesions.

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Oncogene-induced telomere dysf ...... uman cancer precursor lesions.

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Oncogene-induced telomere dysf ...... uman cancer precursor lesions.

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Oncogene-induced telomere dysf ...... uman cancer precursor lesions.

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The EMBO Journal

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Oncogene-induced telomere dysf ...... uman cancer precursor lesions.

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Anitha Suram

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Aurora Cerutti

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Haihe Ruan

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Jessica Kaplunov

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Manoor Prakash Hande

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Neena Mirani

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Priyanka L Patel

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Raffaella Di Micco

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Resham Lal Gurung

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Utz Herbig

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P2860

Hallmarks of Cancer: The Next Generation

TRF2 and apollo cooperate with topoisomerase 2alpha to protect human telomeres from replicative damage

Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)

Five dysfunctional telomeres predict onset of senescence in human cells

Molecular dissection of formation of senescence-associated heterochromatin foci

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

c-Myc accelerates S-phase and requires WRN to avoid replication stress

Creation of human tumour cells with defined genetic elements

Accumulation of senescent cells in mitotic tissue of aging primates

Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA

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2839-2851

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10.1038/EMBOJ.2012.132

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13

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31

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Fabrizio d'Adda di Fagagna

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2012-05-08T00:00:00Z

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224925094

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22569128

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3395091

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