Kinetics of drug action in disease states: towards physiology-based pharmacodynamic (PBPD) models.

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Importance of Drug Pharmacokinetics at the Site of Action How are growth hormone and insulin-like growth factor-1 reported as markers for drug effectiveness in clinical acromegaly research? A comprehensive methodologic review.

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Kinetics of drug action in disease states: towards physiology-based pharmacodynamic (PBPD) models.

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Kinetics of drug action in dis ...... pharmacodynamic (PBPD) models.

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Kinetics of drug action in dis ...... pharmacodynamic (PBPD) models.

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Kinetics of drug action in dis ...... pharmacodynamic (PBPD) models.

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Kinetics of drug action in dis ...... pharmacodynamic (PBPD) models.

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Meindert Danhof

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P2860

Kinetics of drug action in disease states. XL. Effect of the dialyzable component(s) of uremic blood on theophylline neurotoxicity in rats

Enantioselective high-performance liquid chromatographic analysis of the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin. Application to a pharmacokinetic-pharmacodynamic study in rats

Considerations in the use of cerebrospinal fluid pharmacokinetics to predict brain target concentrations in the clinical setting: implications of the barriers between blood and brain.

Stereoselective transport of baclofen across the blood-brain barrier in rats as determined by the unit impulse response methodology.

Mechanism-based pharmacokinetic-pharmacodynamic modeling of concentration-dependent hysteresis and biphasic electroencephalogram effects of alphaxalone in rats.

Pharmacokinetic-pharmacodynamic modeling of buspirone and its metabolite 1-(2-pyrimidinyl)-piperazine in rats.

Drug treatment effects on disease progression.

Fifth-generation model for corticosteroid pharmacodynamics: application to steady-state receptor down-regulation and enzyme induction patterns during seven-day continuous infusion of methylprednisolone in rats.

Comparison of four basic models of indirect pharmacodynamic responses

The effect of quinidine and its metabolites on the electrocardiogram and systolic time intervals: concentration--effect relationships.

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s10928-015-9437-x

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10.1007/S10928-015-9437-X

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Kinetics of drug action in disease states: towards physiology-based pharmacodynamic (PBPD) models.

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P2860

P2860

Kinetics of drug action in disease states: towards physiology-based pharmacodynamic (PBPD) models.

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