The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and differentiation

The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and differentiation

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http://www.wikidata.org/entity/Q36098246

Q36098246

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Ubiquitin proteasome system research in gastrointestinal cancer Genetic instability in the tumor microenvironment: a new look at an old neighbor The role of cancer-associated fibroblasts in esophageal cancer The tumor microenvironment in esophageal cancer Organotypic culture model of pancreatic cancer demonstrates that stromal cells modulate E-cadherin, beta-catenin, and Ezrin expression in tumor cells.Upregulated human telomerase reverse transcriptase (hTERT) expression is associated with spinal chordoma growth, invasion and poor prognosis.Clinical puzzle: Barrett's oesophagus.Cdx1 and c-Myc foster the initiation of transdifferentiation of the normal esophageal squamous epithelium toward Barrett's esophagus A subpopulation of mouse esophageal basal cells has properties of stem cells with the capacity for self-renewal and lineage specification.Insulin-like growth factor-binding protein-3 promotes transforming growth factor-{beta}1-mediated epithelial-to-mesenchymal transition and motility in transformed human esophageal cells.Hypoxia activates the cyclooxygenase-2-prostaglandin E synthase axis Trp53 haploinsufficiency modifies EGFR-driven peripheral nerve sheath tumorigenesis.Cathepsin B is the driving force of esophageal cell invasion in a fibroblast-dependent manner.Fibroblast-secreted hepatocyte growth factor plays a functional role in esophageal squamous cell carcinoma invasion.Isolation and characterization of mouse and human esophageal epithelial cells in 3D organotypic culture.Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth.High-mobility group A2 protein modulates hTERT transcription to promote tumorigenesis.The role of HGF/MET and FGF/FGFR in fibroblast-derived growth stimulation and lapatinib-resistance of esophageal squamous cell carcinoma.Three-dimensional organotypic culture: experimental models of mammalian biology and disease.UBE2D3 is a positive prognostic factor and is negatively correlated with hTERT expression in esophageal cancer.Review: Experimental models for Barrett's esophagus and esophageal adenocarcinoma Cox2 and β-catenin/T-cell factor signaling intestinalize human esophageal keratinocytes when cultured under organotypic conditions BMP-driven NRF2 activation in esophageal basal cell differentiation and eosinophilic esophagitis WNT10A promotes an invasive and self-renewing phenotype in esophageal squamous cell carcinoma.Decorin antagonizes the angiogenic network: concurrent inhibition of Met, hypoxia inducible factor 1α, vascular endothelial growth factor A, and induction of thrombospondin-1 and TIMP3.Akt2 knock-down reveals its contribution to human lung cancer cell proliferation, growth, motility, invasion and endothelial cell tube formation Development and characterization of an organotypic model of Barrett's esophagus Adenoviral-based immunotherapy provides local disease control in an orthotopic murine model of esophageal cancer.Novel 5-fluorouracil-resistant human esophageal squamous cell carcinoma cells with dihydropyrimidine dehydrogenase overexpression.Phosphatidic Acid (PA) can Displace PPARα/LXRα Binding to The EGFR Promoter Causing its Transrepression in Luminal Cancer Cells Loss of Stromal IMP1 Promotes a Tumorigenic Microenvironment in the Colon.Esophageal epithelial and mesenchymal cross-talk leads to features of epithelial to mesenchymal transition in vitro.An hTERT/ZEB1 complex directly regulates E-cadherin to promote epithelial-to-mesenchymal transition (EMT) in colorectal cancer ERK2-regulated TIMP1 induces hyperproliferation of K-Ras(G12D)-transformed pancreatic ductal cells.A miR-34a-SIRT6 axis in the squamous cell differentiation network Negative control of CSL gene transcription by stress/DNA damage response and p53.Periostin cooperates with mutant p53 to mediate invasion through the induction of STAT1 signaling in the esophageal tumor microenvironment.Induction of intestinalization in human esophageal keratinocytes is a multistep process ERBBs in the gastrointestinal tract: recent progress and new perspectives.Genetic ablation of Smoothened in pancreatic fibroblasts increases acinar-ductal metaplasia.

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P2860

The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and differentiation

Item

http://www.wikidata.org/entity/Q36098246

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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2007年论文

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2007年论文

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name

The functional interplay betwe ...... invasion, and differentiation

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The functional interplay betwe ...... invasion, and differentiation

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The functional interplay betwe ...... invasion, and differentiation

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P1476

The functional interplay betwe ...... invasion, and differentiation

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P2093

Andres J Klein-Szanto

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Anil K Rustgi

http://www.w3.org/2001/XMLSchema#string

Cameron N Johnstone

http://www.w3.org/2001/XMLSchema#string

Carmen Z Michaylira

http://www.w3.org/2001/XMLSchema#string

Claudia D Andl

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Douglas B Stairs

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Edna Cukierman

http://www.w3.org/2001/XMLSchema#string

Hiroshi Nakagawa

http://www.w3.org/2001/XMLSchema#string

Jiri Kalabis

http://www.w3.org/2001/XMLSchema#string

Takaomi Okawa

http://www.w3.org/2001/XMLSchema#string

P2860

Epidermal growth factor receptor mediates increased cell proliferation, migration, and aggregation in esophageal keratinocytes in vitro and in vivo

Tensional homeostasis and the malignant phenotype

Cancer genes and the pathways they control

Cancer metastasis: building a framework

Mitogen-activated protein kinase (MAPK) regulates the expression of progelatinase B (MMP-9) in breast epithelial cells.

Genetic steps in the development of squamous cell carcinoma of the esophagus.

Tumors are unique organs defined by abnormal signaling and context.

Metastatic potential correlates with enzymatic degradation of basement membrane collagen.

Stroma-derived three-dimensional matrices are necessary and sufficient to promote desmoplastic differentiation of normal fibroblasts.

Genetic alterations in esophageal cancer.

P304

2788-2803

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scholarly article

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10.1101/GAD.1544507

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2007-11-01T00:00:00Z

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5871316

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17974918

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overexpression

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2045132

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The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and differentiation

about

P2860

P2860

The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and differentiation

description

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P1433

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