NEMO ensures signaling specificity of the pleiotropic IKKβ by directing its kinase activity toward IκBα.
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Crystal Structure of a Human I B Kinase Asymmetric DimerMolecular basis for specificity of the Met1-linked polyubiquitin signalTPL2 mediates autoimmune inflammation through activation of the TAK1 axis of IL-17 signaling.A structural basis for IκB kinase 2 activation via oligomerization-dependent trans auto-phosphorylationThe IκB kinase complex in NF-κB regulation and beyond.IKKβ in postnatal perichondrium remotely controls endochondral ossification of the growth plate through downregulation of MCP-5.Inhibition of Canonical NF-κB Signaling by a Small Molecule Targeting NEMO-Ubiquitin InteractionChromosome instability in diffuse large B cell lymphomas is suppressed by activation of the noncanonical NF-κB pathway.Myeloid Deletion of Nemo Causes Osteopetrosis in Mice Owing to Upregulation of Transcriptional Repressors.The dynamics of signaling as a pharmacological target.IκB kinase γ/nuclear factor-κB-essential modulator (IKKγ/NEMO) facilitates RhoA GTPase activation, which, in turn, activates Rho-associated KINASE (ROCK) to phosphorylate IKKβ in response to transforming growth factor (TGF)-β1Molecular control of the NEMO family of ubiquitin-binding proteins.Non-conventional functions for NF-κB members: the dark side of NF-κB.Topology, dynamics, and heterogeneity in immune signaling.Signaling via the NFκB system.Distinct single-cell signaling characteristics are conferred by the MyD88 and TRIF pathways during TLR4 activation.Disulfide-mediated stabilization of the IκB kinase binding domain of NF-κB essential modulator (NEMO).Kelch-like Protein 21 (KLHL21) Targets IκB Kinase-β to Regulate Nuclear Factor κ-Light Chain Enhancer of Activated B Cells (NF-κB) Signaling Negatively.The red edge excitation shift phenomenon can be used to unmask protein structural ensembles: implications for NEMO-ubiquitin interactions.Mutation of nonessential cysteines shows that the NF-κB essential modulator forms a constitutive noncovalent dimer that binds IκB kinase-β with high affinity.Rts1-protein phosphatase 2A antagonizes Ptr3-mediated activation of the signaling protease Ssy5 by casein kinase I.Polyubiquitin Drives the Molecular Interactions of the NF-κB Essential Modulator (NEMO) by Allosteric Regulation.Interleukin-1 and TRAF6-dependent activation of TAK1 in the absence of TAB2 and TAB3Two-sided ubiquitin binding of NF-κB essential modulator (NEMO) zinc finger unveiled by a mutation associated with anhidrotic ectodermal dysplasia with immunodeficiency syndrome.ANGPTL8 negatively regulates NF-κB activation by facilitating selective autophagic degradation of IKKγ.CYLD Deubiquitinase Negatively Regulates High Glucose-Induced NF-κB Inflammatory Signaling in Mesangial Cells.
P2860
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P2860
NEMO ensures signaling specificity of the pleiotropic IKKβ by directing its kinase activity toward IκBα.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
NEMO ensures signaling specifi ...... s kinase activity toward IκBα.
@ast
NEMO ensures signaling specifi ...... s kinase activity toward IκBα.
@en
type
label
NEMO ensures signaling specifi ...... s kinase activity toward IκBα.
@ast
NEMO ensures signaling specifi ...... s kinase activity toward IκBα.
@en
prefLabel
NEMO ensures signaling specifi ...... s kinase activity toward IκBα.
@ast
NEMO ensures signaling specifi ...... s kinase activity toward IκBα.
@en
P2093
P2860
P1433
P1476
NEMO ensures signaling specifi ...... s kinase activity toward IκBα.
@en
P2093
Alexander Hoffmann
Bärbel Schröfelbauer
Gourisankar Ghosh
Marcelo Behar
Smarajit Polley
P2860
P304
P356
10.1016/J.MOLCEL.2012.04.020
P577
2012-05-24T00:00:00Z