Genome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis. - Wikidata - awgldk - TriplyDB

Genome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis.

Genome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis.

http://www.wikidata.org/entity/Q36108378

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CFTR Modulators: Shedding Light on Precision Medicine for Cystic Fibrosis Ribosomal Stalk Protein Silencing Partially Corrects the ΔF508-CFTR Functional Expression Defect Barriers to inhaled gene therapy of obstructive lung diseases: A review An overview of international literature from cystic fibrosis registries. Part 5: Update 2012-2015 on lung disease.Loss of SLC9A3 decreases CFTR protein and causes obstructed azoospermia in mice.Long Non-coding RNA BGas Regulates the Cystic Fibrosis Transmembrane Conductance Regulator Using Drugs to Probe the Variability of Trans-Epithelial Airway Resistance.Reverse Pathway Genetic Approach Identifies Epistasis in Autism Spectrum Disorders.In silico search for modifier genes associated with pancreatic and liver disease in Cystic Fibrosis Early Lung Function Decline in Cystic Fibrosis: Can Registry Data Explain Divergent Phenotypes?Novel variation at chr11p13 associated with cystic fibrosis lung disease severity.Genome sequencing in a case of Niemann-Pick type C Single-cell RNA sequencing identifies diverse roles of epithelial cells in idiopathic pulmonary fibrosis.Retinoic acid catabolizing enzyme CYP26C1 is a genetic modifier in SHOX deficiency.DNA methylation at modifier genes of lung disease severity is altered in cystic fibrosis.Airway Mucosal Host Defense is Key to Genomic Regulation of Cystic Fibrosis Lung Disease Severity.Glutamine transporters in mammalian cells and their functions in physiology and cancer.Ets homologous factor (EHF) has critical roles in epithelial dysfunction in airway disease.Restoration of R117H CFTR folding and function in human airway cells through combination treatment with VX-809 and VX-770 Computation of ancestry scores with mixed families and unrelated individuals.Are genetic polymorphisms in the renin-angiotensin-aldosterone system associated with essential hypertension? Evidence from genome-wide association studies.Impact of gene editing on the study of cystic fibrosis.Pharmacogenetics of cystic fibrosis treatment.Exploiting the potential of next-generation sequencing in genomic medicine.Clinical approach to the diagnosis and treatment of cystic fibrosis and CFTR-related disorders.From Peas to Disease: Modifier Genes, Network Resilience, and the Genetics of Health.The Sweat Metabolome of Screen-Positive Cystic Fibrosis Infants: Revealing Mechanisms beyond Impaired Chloride Transport.Cystic fibrosis gene modifier SLC26A9 modulates airway response to CFTR-directed therapeutics.IL8 gene as modifier of cystic fibrosis: unraveling the factors which influence clinical variability.Transcriptomic profile of cystic fibrosis patients identifies type I interferon response and ribosomal stalk proteins as potential modifiers of disease severity Increased Expression of Plasma-Induced ABCC1 mRNA in Cystic Fibrosis.Goblet Cell Hyperplasia Requires High Bicarbonate Transport To Support Mucin Release.Regulatory dynamics of 11p13 suggest a role for EHF in modifying CF lung disease severity.The population genetics of human disease: The case of recessive, lethal mutations.Lessons learned from the search for genes responsible for rare Mendelian disorders.Recent progress in translational cystic fibrosis research using precision medicine strategies.Correlations between cystic fibrosis genotype and sinus disease severity in chronic rhinosinusitis.SLC6A14 Is a Genetic Modifier of Cystic Fibrosis That Regulates Pseudomonas aeruginosa Attachment to Human Bronchial Epithelial Cells.SLC9A3 Protein Is Critical for Acrosomal Formation in Postmeiotic Male Germ Cells.TGFβ as a therapeutic target in cystic fibrosis.

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Genome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis.

http://www.wikidata.org/entity/Q36108378

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Genome-wide association meta-a ...... e severity in cystic fibrosis.

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Genome-wide association meta-a ...... e severity in cystic fibrosis.

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Genome-wide association meta-a ...... e severity in cystic fibrosis.

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Genome-wide association meta-a ...... e severity in cystic fibrosis.

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Genome-wide association meta-a ...... e severity in cystic fibrosis.

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Genome-wide association meta-a ...... e severity in cystic fibrosis.

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Nature Communications

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Genome-wide association meta-a ...... e severity in cystic fibrosis.

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Annick Clement

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Anthony T Dang

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Arianna Franca

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Fan Lin

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Frank J Accurso

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Fred A Wright

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Garry R Cutting

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Hara Levy

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Hong Dang

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Jaclyn R Stonebraker

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Spirometric reference values from a sample of the general U.S. population

Estimation of significance thresholds for genomewide association scans

Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death

Biological insights from 108 schizophrenia-associated genetic loci

Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia

PLINK: a tool set for whole-genome association and population-based linkage analyses

Cystic fibrosis therapeutics: the road ahead

Structural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzyme

HLA-DRB1 and HLA-DQB1 genes on susceptibility to and protection from allergic bronchopulmonary aspergillosis in patients with cystic fibrosis

Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function

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10.1038/NCOMMS9382

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6

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Scott M Blackman

Michael V Patrone

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2015-09-29T00:00:00Z

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282327285

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1023757952

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26417704

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genome-wide association study

cystic fibrosis

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4589222

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