Rho kinase, a promising drug target for neurological disorders. - Wikidata - awgldk - TriplyDB

Rho kinase, a promising drug target for neurological disorders.

Rho kinase, a promising drug target for neurological disorders.

http://www.wikidata.org/entity/Q36111908

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A possible role for integrin signaling in diffuse axonal injury Drug therapy for chronic idiopathic axonal polyneuropathy Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarity Regulation of RhoA-dependent ROCKII activation by Shp2 Phosphorylation of profilin by ROCK1 regulates polyglutamine aggregation Inhibition of rho kinase enhances survival of dopaminergic neurons and attenuates axonal loss in a mouse model of Parkinson's disease Comparative gene expression profiling in three primary human cell lines after treatment with a novel inhibitor of Rho kinase or atorvastatin GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo The cytoskeletal arrangements necessary to neurogenesis Non-muscle myosin II in disease: mechanisms and therapeutic opportunities Small-molecule-induced Rho-inhibition: NSAIDs after spinal cord injury Role of Nonmuscle Myosin II in Migration of Wharton's Jelly-Derived Mesenchymal Stem Cells.Simulated cytoskeletal collapse via tau degradation The RhoA-ROCK pathway in the regulation of T and B cell responses Rho kinase as a target for cerebral vascular disorders Peptide substrates for Rho-associated kinase 2 (Rho-kinase 2/ROCK2)The smooth muscle-selective RhoGAP GRAF3 is a critical regulator of vascular tone and hypertension Abl2/Arg controls dendritic spine and dendrite arbor stability via distinct cytoskeletal control pathways RGMa inhibition promotes axonal growth and recovery after spinal cord injury.Mutant huntingtin alters cell fate in response to microtubule depolymerization via the GEF-H1-RhoA-ERK pathway Integrin-linked kinase is required for radial sorting of axons and Schwann cell remyelination in the peripheral nervous system Coordination of actin filament and microtubule dynamics during neurite outgrowth.The role of repulsive guidance molecules in the embryonic and adult vertebrate central nervous system.Stimulating neuroregeneration as a therapeutic drug approach for traumatic brain injury.Cholesterol Perturbation in Mice Results in p53 Degradation and Axonal Pathology through p38 MAPK and Mdm2 Activation.The Rho/Rac exchange factor Vav2 controls nitric oxide-dependent responses in mouse vascular smooth muscle cells.Targeting a dominant negative rho kinase to neurons promotes axonal outgrowth and partial functional recovery after rat rubrospinal tract lesion.Targeting protein kinases in central nervous system disorders ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability.ROCK2 is a major regulator of axonal degeneration, neuronal death and axonal regeneration in the CNS.Fasudil mesylate protects PC12 cells from oxidative stress injury via the Bax-mediated pathway.Simvastatin improves clinical scores in a rabbit multiple infarct ischemic stroke model: synergism with a ROCK inhibitor but not the thrombolytic tissue plasminogen activator.Gankyrin plays an essential role in Ras-induced tumorigenesis through regulation of the RhoA/ROCK pathway in mammalian cells.Effects of Y-39983, a selective Rho-associated protein kinase inhibitor, on blood flow in optic nerve head in rabbits and axonal regeneration of retinal ganglion cells in rats.Ibuprofen enhances recovery from spinal cord injury by limiting tissue loss and stimulating axonal growth.Novel molecular imaging platform for monitoring oncological kinases.Protein kinases CK1 and CK2 as new targets for neurodegenerative diseases.Viral vector-mediated downregulation of RhoA increases survival and axonal regeneration of retinal ganglion cells.Ser1333 phosphorylation indicates ROCKI activation.Rho/ROCK signaling in motility and metastasis of gastric cancer

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Rho kinase, a promising drug target for neurological disorders.

http://www.wikidata.org/entity/Q36111908

description

2005 nî lūn-bûn

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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2005年论文

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Rho kinase, a promising drug target for neurological disorders.

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Rho kinase, a promising drug target for neurological disorders.

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Rho kinase, a promising drug target for neurological disorders.

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Rho kinase, a promising drug target for neurological disorders.

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Nature Reviews Drug Discovery

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Rho kinase, a promising drug target for neurological disorders.

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P2093

Bernhard K Mueller

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Helmut Mack

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P2860

Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop

Myotonic dystrophy protein kinase domains mediate localization, oligomerization, novel catalytic activity, and autoinhibition

Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase

Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration

Intermolecular and intramolecular interactions regulate catalytic activity of myotonic dystrophy kinase-related Cdc42-binding kinase alpha

Structural insights into the interaction of ROCKI with the switch regions of RhoA

The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton

Rho activation patterns after spinal cord injury and the role of activated Rho in apoptosis in the central nervous system

Modulation of statin-activated shedding of Alzheimer APP ectodomain by ROCK

Parallel coiled-coil association of the RhoA-binding domain in Rho-kinase

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387-398

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10.1038/NRD1719

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