Epitope mapping of monoclonal antibodies specific for the 190-kDa multidrug resistance protein (MRP).
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Development and characterization of a recombinant Madin-Darby canine kidney cell line that expresses rat multidrug resistance-associated protein 1 (rMRP1)Identification by phage display of the linear continuous MRPr1 epitope in the multidrug resistance-associated protein (MRP1).Inhibition of the MRP1-mediated transport of the menadione-glutathione conjugate (thiodione) in HeLa cells as studied by SECM.Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins.Microglial activation decreases retention of the protease inhibitor saquinavir: implications for HIV treatment.Determinants of the substrate specificity of multidrug resistance protein 1: role of amino acid residues with hydrogen bonding potential in predicted transmembrane helix 17.Arsenic Triglutathione [As(GS)3] Transport by Multidrug Resistance Protein 1 (MRP1/ABCC1) Is Selectively Modified by Phosphorylation of Tyr920/Ser921 and Glycosylation of Asn19/Asn23.The glutathione S-transferase inhibitor 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol overcomes the MDR1-P-glycoprotein and MRP1-mediated multidrug resistance in acute myeloid leukemia cells.Role of GSH in estrone sulfate binding and translocation by the multidrug resistance protein 1 (MRP1/ABCC1).Identification and characterization of functionally important elements in the multidrug resistance protein 1 COOH-terminal region.Functional importance of polar and charged amino acid residues in transmembrane helix 14 of multidrug resistance protein 1 (MRP1/ABCC1): identification of an aspartate residue critical for conversion from a high to low affinity substrate binding staPhotolabeling of human and murine multidrug resistance protein 1 with the high affinity inhibitor [125I]LY475776 and azidophenacyl-[35S]glutathione.Role of the N-terminal transmembrane region of the multidrug resistance protein MRP2 in routing to the apical membrane in MDCKII cells.Characterization of binding of leukotriene C4 by human multidrug resistance protein 1: evidence of differential interactions with NH2- and COOH-proximal halves of the protein.Identification of a nonconserved amino acid residue in multidrug resistance protein 1 important for determining substrate specificity: evidence for functional interaction between transmembrane helices 14 and 17.Identification of an amino acid residue in multidrug resistance protein 1 critical for conferring resistance to anthracyclines.Expression of the multidrug resistance-associated protein in myelodysplastic syndromes.Mutation of Glu521 or Glu535 in cytoplasmic loop 5 causes differential misfolding in multiple domains of multidrug and organic anion transporter MRP1 (ABCC1)Mrp1 localization and function in cardiac mitochondria after doxorubicin.GSH-dependent photolabeling of multidrug resistance protein MRP1 (ABCC1) by [125I]LY475776. Evidence of a major binding site in the COOH-proximal membrane spanning domain.Identification of domains participating in the substrate specificity and subcellular localization of the multidrug resistance proteins MRP1 and MRP2.Role of carboxylate residues adjacent to the conserved core Walker B motifs in the catalytic cycle of multidrug resistance protein 1 (ABCC1).Multidrug resistance-associated protein (MRP1) gene is strongly expressed in gastric carcinomas. Analysis by immunohistochemistry and real-time quantitative RT-PCR.Monoclonal antibodies that inhibit the transport function of the 190-kDa multidrug resistance protein, MRP. Localization of their epitopes to the nucleotide-binding domains of the protein.
P2860
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P2860
Epitope mapping of monoclonal antibodies specific for the 190-kDa multidrug resistance protein (MRP).
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Epitope mapping of monoclonal ...... drug resistance protein (MRP).
@ast
Epitope mapping of monoclonal ...... drug resistance protein (MRP).
@en
type
label
Epitope mapping of monoclonal ...... drug resistance protein (MRP).
@ast
Epitope mapping of monoclonal ...... drug resistance protein (MRP).
@en
prefLabel
Epitope mapping of monoclonal ...... drug resistance protein (MRP).
@ast
Epitope mapping of monoclonal ...... drug resistance protein (MRP).
@en
P2093
P2860
P356
P1476
Epitope mapping of monoclonal ...... drug resistance protein (MRP).
@en
P2093
P2860
P2888
P304
P356
10.1038/BJC.1998.642
P407
P577
1998-11-01T00:00:00Z